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Gene Review

PIP  -  prolactin-induced protein

Homo sapiens

Synonyms: GCDFP-15, GCDFP15, GPIP4, Gross cystic disease fluid protein 15, Prolactin-induced protein, ...
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Disease relevance of PIP


Psychiatry related information on PIP


High impact information on PIP

  • We have purified these activities and found that the principal IL-2-inducible component bears significant relatedness to a prolactin-induced transcription factor first identified in sheep mammary gland tissue [9].
  • Increased plasma levels of GCDFP-15 were reflected in increased urinary excretion of the glycoprotein [10].
  • Nine (90%) of 10 patients who had 50% increases in plasma GCDFP-15 during initial androgen therapy also had significant decreases in plasma GCDFP-15 following termination of therapy [10].
  • Data on 3 prospectively studied patients demonstrated that plasma GCDFP-15 rose within 24 hours of initiation of fluoxymesterone therapy and continued to rise for at least 6 days [10].
  • Anandamide suppressed the levels of the long form of the prolactin receptor in both EFM-19 and MCF-7 cells, as well as a typical prolactin-induced response, i.e., the expression of the breast cancer cell susceptibility gene brca1 [11].

Chemical compound and disease context of PIP


Biological context of PIP


Anatomical context of PIP


Associations of PIP with chemical compounds


Physical interactions of PIP

  • The use of the P. pastoris secretory pathway allowed instead the accumulation in the culture medium of a GCDFP-15/gp17 species which retained the ability to bind to CD4 and also most of the biochemical and immunological properties of the native protein [20].
  • Inhibitory effects of anti-prolactin receptor antibodies on prolactin binding in brain and prolactin-induced feeding behavior in ring doves [22].

Regulatory relationships of PIP


Other interactions of PIP


Analytical, diagnostic and therapeutic context of PIP


  1. Structural study of GCDFP-15/gp17 in disease versus physiological conditions using a proteomic approach. Caputo, E., Camarca, A., Moharram, R., Tornatore, P., Thatcher, B., Guardiola, J., Martin, B.M. Biochemistry (2003) [Pubmed]
  2. Mapping the CD4 binding domain of gp17, a glycoprotein secreted from seminal vesicles and breast carcinomas. Basmaciogullari, S., Autiero, M., Culerrier, R., Mani, J.C., Gaubin, M., Mishal, Z., Guardiola, J., Granier, C., Piatier-Tonneau, D. Biochemistry (2000) [Pubmed]
  3. Differential antibody reactivity and CD4 binding of the mammary tumor marker protein GCDFP-15 from breast cyst and its counterparts from exocrine epithelia. Caputo, E., Autiero, M., Mani, J.C., Basmociogullari, S., Piatier-Tonneau, D., Guardiola, J. Int. J. Cancer (1998) [Pubmed]
  4. Primary structure of a new actin-binding protein from human seminal plasma. Schaller, J., Akiyama, K., Kimura, H., Hess, D., Affolter, M., Rickli, E.E. Eur. J. Biochem. (1991) [Pubmed]
  5. Presence of alpha-lactalbumin, epidermal growth factor, epithelial membrane antigen, and gross cystic disease fluid protein (15,000 daltons) in breast cyst fluid. Collette, J., Hendrick, J.C., Jaspar, J.M., Franchimont, P. Cancer Res. (1986) [Pubmed]
  6. Deciphering cryptic proteases. Liz, M.A., Sousa, M.M. Cell. Mol. Life Sci. (2005) [Pubmed]
  7. Preoptic area lesions disrupt prolactin-induced parental feeding behavior in ring doves. Slawski, B.A., Buntin, J.D. Hormones and behavior. (1995) [Pubmed]
  8. Apparent replication of suggestive linkage on chromosome 16 in the NIMH genetics initiative bipolar pedigrees. Dick, D.M., Foroud, T., Edenberg, H.J., Miller, M., Bowman, E., Rau, N.L., DePaulo, J.R., McInnis, M., Gershon, E., McMahon, F., Rice, J.P., Bierut, L.J., Reich, T., Nurnberger, J. Am. J. Med. Genet. (2002) [Pubmed]
  9. Identification and purification of human Stat proteins activated in response to interleukin-2. Hou, J., Schindler, U., Henzel, W.J., Wong, S.C., McKnight, S.L. Immunity (1995) [Pubmed]
  10. Androgen stimulation of gross cystic disease fluid protein and carcinoembryonic antigen in patients with metastatic breast carcinoma. Dilley, W.G., Leight, G.S., Silva, J.S., Ammirata, S., Haagensen, D.E., Wells, S.A. J. Natl. Cancer Inst. (1983) [Pubmed]
  11. The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation. De Petrocellis, L., Melck, D., Palmisano, A., Bisogno, T., Laezza, C., Bifulco, M., Di Marzo, V. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  12. The prolactin-inducible protein (PIP/GCDFP-15) gene: cloning, structure and regulation. Myal, Y., Robinson, D.B., Iwasiow, B., Tsuyuki, D., Wong, P., Shiu, R.P. Mol. Cell. Endocrinol. (1991) [Pubmed]
  13. Inhibitory effect of estrogens on GCDFP-15 mRNA levels and secretion in ZR-75-1 human breast cancer cells. Simard, J., Hatton, A.C., Labrie, C., Dauvois, S., Zhao, H.F., Haagensen, D.E., Labrie, F. Mol. Endocrinol. (1989) [Pubmed]
  14. Cylindroma (dermal analog tumor) of the breast: a comparison with cylindroma of the skin and adenoid cystic carcinoma of the breast. Albores-Saavedra, J., Heard, S.C., McLaren, B., Kamino, H., Witkiewicz, A.K. Am. J. Clin. Pathol. (2005) [Pubmed]
  15. Stimulatory effect of oestradiol-17 beta and tamoxifen on gross cystic disease fluid protein 15,000 production and mRNA levels in T47D human breast cancer cells. Dejardin, L., Gol-Winkler, R., Collette, J., Delvenne, C., Carlisi, I., Haagensen, D.E., Franchimont, P. J. Mol. Endocrinol. (1991) [Pubmed]
  16. Retinoic acid modulates prolactin receptor expression and prolactin-induced STAT-5 activation in breast cancer cells in vitro. Widschwendter, M., Widschwendter, A., Welte, T., Daxenbichler, G., Zeimet, A.G., Bergant, A., Berger, J., Peyrat, J.P., Michel, S., Doppler, W., Marth, C. Br. J. Cancer (1999) [Pubmed]
  17. The coactivator of transcription CREB-binding protein interacts preferentially with the glycosylated form of Stat5. Gewinner, C., Hart, G., Zachara, N., Cole, R., Beisenherz-Huss, C., Groner, B. J. Biol. Chem. (2004) [Pubmed]
  18. Potent inhibition of CD4/TCR-mediated T cell apoptosis by a CD4-binding glycoprotein secreted from breast tumor and seminal vesicle cells. Gaubin, M., Autiero, M., Basmaciogullari, S., Métivier, D., Mis hal, Z., Culerrier, R., Oudin, A., Guardiola, J., Piatier-Tonneau, D. J. Immunol. (1999) [Pubmed]
  19. A novel aspartyl proteinase from apocrine epithelia and breast tumors. Caputo, E., Manco, G., Mandrich, L., Guardiola, J. J. Biol. Chem. (2000) [Pubmed]
  20. Biosynthesis and immunobiochemical characterization of gp17/GCDFP-15. A glycoprotein from seminal vesicles and from breast tumors, in HeLa cells and in Pichia pastoris yeast. Caputo, E., Carratore, V., Ciullo, M., Tiberio, C., Mani, J.C., Piatier-Tonneau, D., Guardiola, J. Eur. J. Biochem. (1999) [Pubmed]
  21. Conversion of threonine 757 to valine enhances Stat5a transactivation potential. Gowri, P.M., Ganguly, T.C., Cao, J., Devalaraja, M.N., Groner, B., Vore, M. J. Biol. Chem. (2001) [Pubmed]
  22. Inhibitory effects of anti-prolactin receptor antibodies on prolactin binding in brain and prolactin-induced feeding behavior in ring doves. Li, C., Kelly, P.A., Buntin, J.D. Neuroendocrinology (1995) [Pubmed]
  23. Prostate-specific antigen and gross cystic disease fluid protein-15 are co-expressed in androgen receptor-positive breast tumours. Hall, R.E., Clements, J.A., Birrell, S.N., Tilley, W.D. Br. J. Cancer (1998) [Pubmed]
  24. Interleukin-4 and interleukin-13 inhibit estrogen-induced breast cancer cell proliferation and stimulate GCDFP-15 expression in human breast cancer cells. Blais, Y., Gingras, S., Haagensen, D.E., Labrie, F., Simard, J. Mol. Cell. Endocrinol. (1996) [Pubmed]
  25. Interleukin-6 inhibits the potent stimulatory action of androgens, glucocorticoids and interleukin-1 alpha on apolipoprotein D and GCDFP-15 expression in human breast cancer cells. Blais, Y., Sugimoto, K., Carrière, M.C., Haagensen, D.E., Labrie, F., Simard, J. Int. J. Cancer (1995) [Pubmed]
  26. Role of vasoactive intestinal peptide in the control of prolactin-induced turkey incubation behavior. I. Acute infusion of vasoactive intestinal peptide. Pitts, G.R., Youngren, O.M., Silsby, J.L., Foster, L.K., Foster, D.N., Rozenboim, I., Phillips, R.E., el Halawani, M.E. Biol. Reprod. (1994) [Pubmed]
  27. Expression of WT1, CA 125, and GCDFP-15 as useful markers in the differential diagnosis of primary ovarian carcinomas versus metastatic breast cancer to the ovary. Tornos, C., Soslow, R., Chen, S., Akram, M., Hummer, A.J., Abu-Rustum, N., Norton, L., Tan, L.K. Am. J. Surg. Pathol. (2005) [Pubmed]
  28. Interaction of seminal plasma proteins with cell surface antigens: presence of a CD4-binding glycoprotein in human seminal plasma. Autiero, M., Abrescia, P., Guardiola, J. Exp. Cell Res. (1991) [Pubmed]
  29. Immunohistochemistry of a gross cystic disease fluid protein (GCDFP-15) of the breast. A marker of apocrine epithelium and breast carcinomas with apocrine features. Mazoujian, G., Pinkus, G.S., Davis, S., Haagensen, D.E. Am. J. Pathol. (1983) [Pubmed]
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