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MeSH Review

Adenoma, Pleomorphic

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Disease relevance of Adenoma, Pleomorphic

  • Thirteen of 17 pleomorphic adenomas with a normal karyotype and 5 of 10 with 12q13-15 abnormalities overexpressed PLAG1, which demonstrates that PLAG1 activation is a frequent event in adenomas irrespective of karyotype [1].
  • Although most of the tumor cells in both malignant melanoma and pleomorphic adenoma were labeled with the anti-sense RNA probe, unlabeled tumor cells were also present in their vicinity, suggesting there was a heterogeneity among the cells in both tumor types with respect to S100 protein mRNA expression [2].
  • At an echo time of 136 msec, Cho/Cr ratios were obtained in 26 (47%) of 55 spectra, with a mean value (+/- standard deviation) of 1.73 +/- 0.47, 5.49 +/- 1.86, 3.46 +/- 0.84, and 2.45 for malignant tumors, Warthin tumors, pleomorphic adenomas, and oncocytoma, respectively [3].
  • Chondroitin 6-sulphate PG was detected in the ECM of pleomorphic adenomas and clear cell carcinomas and in pseudocystic spaces of adenoid cystic carcinomas, but only in vessel walls in non-neoplastic tissues [4].
  • Normal rat and human parotid glands as well as pleomorphic adenomas and squamous cell carcinomas of this gland were examined by the indirect immunoperoxidase technique using antibodies to the keratin polypeptide of 67,000 dalton, and 55,000 dalton and anti-actin auto-antibodies [5].

High impact information on Adenoma, Pleomorphic


Chemical compound and disease context of Adenoma, Pleomorphic


Biological context of Adenoma, Pleomorphic


Anatomical context of Adenoma, Pleomorphic


Gene context of Adenoma, Pleomorphic


Analytical, diagnostic and therapeutic context of Adenoma, Pleomorphic


  1. Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene. Aström, A.K., Voz, M.L., Kas, K., Röijer, E., Wedell, B., Mandahl, N., Van de Ven, W., Mark, J., Stenman, G. Cancer Res. (1999) [Pubmed]
  2. Heterogeneity in expression of S100 beta mRNA in human melanoma and pleomorphic adenoma demonstrated by in situ hybridization. Landry, C.F., Kahn, H.J., Baumal, R., Marks, A., Brown, I.R. Am. J. Pathol. (1991) [Pubmed]
  3. Salivary gland tumors at in vivo proton MR spectroscopy. King, A.D., Yeung, D.K., Ahuja, A.T., Tse, G.M., Yuen, H.Y., Wong, K.T., van Hasselt, A.C. Radiology. (2005) [Pubmed]
  4. Immunohistochemical characterisation of extracellular matrix components of salivary gland tumours. Nara, Y., Takeuchi, J., Yoshida, K., Fukatsu, T., Nagasaka, T., Kawaguchi, T., Meng, N., Kikuchi, H., Nakashima, N. Br. J. Cancer (1991) [Pubmed]
  5. Immunocytochemical demonstration of filamentous structures in the parotid gland. Occurrence of keratin and actin in normal and tumoral parotid gland with special respect to the myoepithelial cells. Caselitz, J., Löning, T., Staquet, M.J., Seifert, G., Thivolet, J. J. Cancer Res. Clin. Oncol. (1981) [Pubmed]
  6. Salivary gland tumors in transgenic mice with targeted PLAG1 proto-oncogene overexpression. Declercq, J., Van Dyck, F., Braem, C.V., Van Valckenborgh, I.C., Voz, M., Wassef, M., Schoonjans, L., Van Damme, B., Fiette, L., Van de Ven, W.J. Cancer Res. (2005) [Pubmed]
  7. The tumorigenic diversity of the three PLAG family members is associated with different DNA binding capacities. Hensen, K., Van Valckenborgh, I.C., Kas, K., Van de Ven, W.J., Voz, M.L. Cancer Res. (2002) [Pubmed]
  8. PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II. Voz, M.L., Agten, N.S., Van de Ven, W.J., Kas, K. Cancer Res. (2000) [Pubmed]
  9. Expression of reciprocal hybrid transcripts of HMGIC and FHIT in a pleomorphic adenoma of the parotid gland. Geurts, J.M., Schoenmakers, E.F., Röijer, E., Stenman, G., Van de Ven, W.J. Cancer Res. (1997) [Pubmed]
  10. Translocation, deletion/amplification, and expression of HMGIC and MDM2 in a carcinoma ex pleomorphic adenoma. Röijer, E., Nordkvist, A., Ström, A.K., Ryd, W., Behrendt, M., Bullerdiek, J., Mark, J., Stenman, G. Am. J. Pathol. (2002) [Pubmed]
  11. Guanylin and functional coupling proteins in the human salivary glands and gland tumors : expression, cellular localization, and target membrane domains. Kulaksiz, H., Rehberg, E., Stremmel, W., Cetin, Y. Am. J. Pathol. (2002) [Pubmed]
  12. Pleomorphic adenoma of the salivary glands: correlation between gallium-67 uptake and histopathological components. Yoshikai, T., Yonemitsu, N., Ishimaru, J., Mihara, M., Shin, T., Kudo, S. J. Nucl. Med. (1998) [Pubmed]
  13. Molecular evidence that the stromal and epithelial cells in pleomorphic adenomas of salivary gland arise from the same origin: clonal analysis using human androgen receptor gene (HUMARA) assay. Lee, P.S., Sabbath-Solitare, M., Redondo, T.C., Ongcapin, E.H. Hum. Pathol. (2000) [Pubmed]
  14. Increased expression of the enzyme beta 1-4-galactosyltransferase is associated with human parotid neoplasms. Humphreys-Beher, M.G., Maeda, N., Purushotham, K.R., Morgan, A., Cassisi, N. Proc. Soc. Exp. Biol. Med. (1990) [Pubmed]
  15. The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter. Voz, M.L., Aström, A.K., Kas, K., Mark, J., Stenman, G., Van de Ven, W.J. Oncogene (1998) [Pubmed]
  16. Alterations of the INK4a-ARF gene locus in pleomorphic adenoma of the parotid gland. Weber, A., Langhanki, L., Schütz, A., Wittekind, C., Bootz, F., Tannapfel, A. J. Pathol. (2002) [Pubmed]
  17. Histologic localization of PLAG1 (pleomorphic adenoma gene 1) in pleomorphic adenoma of the salivary gland: cytogenetic evidence of common origin of phenotypically diverse cells. Debiec-Rychter, M., Van Valckenborgh, I., Van den Broeck, C., Hagemeijer, A., Van de Ven, W.J., Kas, K., Van Damme, B., Voz, M.L. Lab. Invest. (2001) [Pubmed]
  18. PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using chromosome banding, in situ hybridization and immunocytochemistry. Martins, C., Fonseca, I., Roque, L., Pereira, T., Ribeiro, C., Bullerdiek, J., Soares, J. Mod. Pathol. (2005) [Pubmed]
  19. Cartilage-specific matrix protein chondromodulin-I is associated with chondroid formation in salivary pleomorphic adenomas: immunohistochemical analysis. Kusafuka, K., Hiraki, Y., Shukunami, C., Yamaguchi, A., Kayano, T., Takemura, T. Am. J. Pathol. (2001) [Pubmed]
  20. Muscle-specific protein expression in normal salivary glands and pleomorphic adenomas: an immunocytochemical study with biochemical confirmation. Zarbo, R.J., Bacchi, C.E., Gown, A.M. Mod. Pathol. (1991) [Pubmed]
  21. Hepatocellular carcinoma with solitary metastasis in pleomorphic adenoma of the submandibular gland. Ichikawa, T., Takagi, H., Abe, T., Ito, H., Nagamine, T., Mori, M. Histopathology (2001) [Pubmed]
  22. Cell membrane expression of MIB-1 in salivary gland pleomorphic adenoma. Tashiro, T., Hirokawa, M., Harada, H., Yokoyama, S., Sano, T. Histopathology (2002) [Pubmed]
  23. Are myoepithelial cells responsible for the widespread expression of inducible nitric oxide synthase in pleomorphic adenoma? An immunohistochemical study. Brennan, P.A., Umar, T., Zaki, G.A., Langdon, J.D., Spedding, A., Buckley, J., Downie, I.P. J. Oral Pathol. Med. (2000) [Pubmed]
  24. Identification of NFIB as recurrent translocation partner gene of HMGIC in pleomorphic adenomas. Geurts, J.M., Schoenmakers, E.F., Röijer, E., Aström, A.K., Stenman, G., van de Ven, W.J. Oncogene (1998) [Pubmed]
  25. An immunohistochemical study of pleomorphic adenomas of the salivary gland: glial fibrillary acidic protein-like immunoreactivity identifies a major myoepithelial component. Stead, R.H., Qizilbash, A.H., Kontozoglou, T., Daya, A.D., Riddell, R.H. Hum. Pathol. (1988) [Pubmed]
  26. Expression of S100A2 and S100B proteins in epithelial tumors of the skin. Park, H.R., Min, S.K. J. Cutan. Pathol. (2003) [Pubmed]
  27. Precancerous foci in pleomorphic adenoma of the salivary gland: recognition of focal carcinoma and atypical tumor cells by P53 immunohistochemistry. Ohtaké, S., Cheng, J., Ida, H., Suzuki, M., Ohshiro, K., Zhang, W., Saku, T. J. Oral Pathol. Med. (2002) [Pubmed]
  28. Expression of bone morphogenetic proteins in salivary pleomorphic adenomas. Kusafuka, K., Yamaguchi, A., Kayano, T., Fujiwara, M., Takemura, T. Virchows Arch. (1998) [Pubmed]
  29. Structural alterations of the c-mos locus in benign pleomorphic adenomas with chromosome abnormalities of 8q12. Stenman, G., Sahlin, P., Mark, J., Landys, D. Oncogene (1991) [Pubmed]
  30. Localization of S-100 protein and glial fibrillary acidic protein-related antigen in pleomorphic adenoma of the salivary glands. Nakazato, Y., Ishizeki, J., Takahashi, K., Yamaguchi, H., Kamei, T., Mori, T. Lab. Invest. (1982) [Pubmed]
  31. Synthesis of elastin by pleomorphic adenomas. Grosso, L.E. J. Oral Pathol. Med. (1996) [Pubmed]
  32. Vascular endothelial growth factor in salivary pleomorphic adenomas: one of the reasons for their poorly vascularized stroma. Swelam, W., Ida-Yonemochi, H., Maruyama, S., Ohshiro, K., Cheng, J., Saku, T. Virchows Arch. (2005) [Pubmed]
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