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MeSH Review

Carcinoma, Adenoid Cystic

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Disease relevance of Carcinoma, Adenoid Cystic


High impact information on Carcinoma, Adenoid Cystic

  • Here we have identified CYLD by detecting germline mutations in 21 cylindromatosis families and somatic mutations in 1 sporadic and 5 familial cylindromas [4].
  • In the present study, we show that mice ectopically expressing the human Cubitus interruptus homolog GLI-1 in the skin develop tumors closely resembling human BCCs as well as other hair follicle-derived neoplasias, such as trichoepitheliomas, cylindromas, and trichoblastomas [5].
  • To determine the molecular defects leading to extracellular matrix accumulation, the ultrastructural, immunological, and biochemical properties of cylindroma tissue and isolated cells were analyzed [6].
  • Brooke-Spiegler syndrome (BSS, familial cylindromatosis or turban tumor syndrome) is an inherited disease characterized by neoplasms of the skin appendages such as cylindroma, trichoepithelioma, and spiradenoma [7].
  • Cytokeratin 7 labeled predominantly the central basaloid cells, and smooth muscle actin stained peripheral myoepithelial cells in breast and dermal cylindromas [8].

Chemical compound and disease context of Carcinoma, Adenoid Cystic


Biological context of Carcinoma, Adenoid Cystic


Anatomical context of Carcinoma, Adenoid Cystic

  • Basement membrane components and keratin in the dominantly inherited form of cylindroma [11].
  • All spiradenomas and cylindromas we studied demonstrated actin and/or S-100 protein positivity in basal epithelial cells, consistent with myoepithelial differentiation [12].
  • Human milk fat globulin (HMFG) and lysozyme, two markers associated with apocrine differentiation, are expressed by tubular cells in spiradenomas and cylindromas [13].
  • Two of three eccrine hidradenocarcinomas, and two of three porocarcinomas presented p53 overexpression, whereas in one case of malignant cylindroma and adenoid cystic carcinoma we did not find p53-positivity [14].

Gene context of Carcinoma, Adenoid Cystic


  1. Unusual combination of Cis platinum and radiotherapy followed by a three fractions per day irradiation in splitcourse: a phase I-II study in brain glioma patients. Ben-Hassel, M., Lesimple, T., Gedouin, D., Chenal, C., Guegan, Y., Darcel, F. Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]. (1992) [Pubmed]
  2. p63, a p53 homologue, is a selective nuclear marker of myoepithelial cells of the human breast. Barbareschi, M., Pecciarini, L., Cangi, M.G., Macrì, E., Rizzo, A., Viale, G., Doglioni, C. Am. J. Surg. Pathol. (2001) [Pubmed]
  3. Primary Bartholin gland carcinoma: a report of seven cases. Obermair, A., Koller, S., Crandon, A.J., Perrin, L., Nicklin, J.L. The Australian & New Zealand journal of obstetrics & gynaecology. (2001) [Pubmed]
  4. Identification of the familial cylindromatosis tumour-suppressor gene. Bignell, G.R., Warren, W., Seal, S., Takahashi, M., Rapley, E., Barfoot, R., Green, H., Brown, C., Biggs, P.J., Lakhani, S.R., Jones, C., Hansen, J., Blair, E., Hofmann, B., Siebert, R., Turner, G., Evans, D.G., Schrander-Stumpel, C., Beemer, F.A., van Den Ouweland, A., Halley, D., Delpech, B., Cleveland, M.G., Leigh, I., Leisti, J., Rasmussen, S. Nat. Genet. (2000) [Pubmed]
  5. Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1. Nilsson, M., Undèn, A.B., Krause, D., Malmqwist, U., Raza, K., Zaphiropoulos, P.G., Toftgård, R. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  6. Defective laminin 5 processing in cylindroma cells. Tunggal, L., Ravaux, J., Pesch, M., Smola, H., Krieg, T., Gaill, F., Sasaki, T., Timpl, R., Mauch, C., Aumailley, M. Am. J. Pathol. (2002) [Pubmed]
  7. A novel missense mutation in CYLD in a family with Brooke-Spiegler syndrome. Hu, G., Onder, M., Gill, M., Aksakal, B., Oztas, M., Gürer, M.A., Celebi, J.T. J. Invest. Dermatol. (2003) [Pubmed]
  8. Cylindroma (dermal analog tumor) of the breast: a comparison with cylindroma of the skin and adenoid cystic carcinoma of the breast. Albores-Saavedra, J., Heard, S.C., McLaren, B., Kamino, H., Witkiewicz, A.K. Am. J. Clin. Pathol. (2005) [Pubmed]
  9. Epithelial markers and differentiation in adnexal neoplasms of the skin: an immunohistochemical study including individual cytokeratins. Demirkesen, C., Hoede, N., Moll, R. J. Cutan. Pathol. (1995) [Pubmed]
  10. The cylindromatosis gene (cyld1) on chromosome 16q may be the only tumour suppressor gene involved in the development of cylindromas. Biggs, P.J., Chapman, P., Lakhani, S.R., Burn, J., Stratton, M.R. Oncogene (1996) [Pubmed]
  11. Basement membrane components and keratin in the dominantly inherited form of cylindroma. Oikarinen, A., Peltonen, L. Acta Derm. Venereol. (1985) [Pubmed]
  12. Sweat gland adenomas: immunohistochemical study with emphasis on myoepithelial differentiation. Wiley, E.L., Milchgrub, S., Freeman, R.G., Kim, E.S. J. Cutan. Pathol. (1993) [Pubmed]
  13. Spiradenoma and dermal cylindroma: comparative immunohistochemical analysis and histogenetic considerations. Meybehm, M., Fischer, H.P. The American Journal of dermatopathology. (1997) [Pubmed]
  14. p53 expression in sweat gland tumors. Biernat, W., Woźniak, L. Polish journal of pathology : official journal of the Polish Society of Pathologists. (1996) [Pubmed]
  15. CD44 distribution in sweat gland tumors suggests it has different functional roles in the various cell types. Fernández-Figueras, M.T., Puig, L., Ariza, A., Calatrava, A., Fuente, M.J., Ferrándiz, C. The American Journal of dermatopathology. (1996) [Pubmed]
  16. A nevoid plaque with histological changes of trichoepithelioma and cylindroma in Brooke-Spiegler syndrome. An immunohistochemical study with cytokeratins. Schirren, C.G., Wörle, B., Kind, P., Plewig, G. J. Cutan. Pathol. (1995) [Pubmed]
  17. A comparison of the expression of known basement membrane components with the linear IgA disease antigens using the novel substrate cylindroma. Wojnarowska, F., Allen, J., Collier, P.M., Leigh, I.M. Br. J. Dermatol. (1999) [Pubmed]
  18. Distinct expression patterns of alpha1 (IV) and alpha5 (IV) collagen chains in cylindroma and malignant cylindroma. Quatresooz, P., Piérard, G.E. Int. J. Mol. Med. (2005) [Pubmed]
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