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Disease relevance of Megaloblasts


High impact information on Megaloblasts

  • Early megaloblasts, especially in severe megaloblastosis, showed a marked decrease in C3b receptor activity, again in proportion to the level of maturation arrest [2].
  • In conclusion, the expression of HLA class I and II Ag is not detected on primitive megaloblasts, but is gradually induced on definitive FL progenitors and precursors, possibly via production of specific cytokines in the FL microenvironment, i.e., IFN-gamma and TNF-alpha for class I Ag and IL-1 beta for class II Ag [3].
  • Prior to therapy ineffective erythropoiesis was grossly increased but this was reversed within 24 h of giving vitamin B12, suggesting that most of the existing megaloblasts are enabled to mature into circulating red cells [4].
  • The biopsies were embedded in wax and in epoxy resin, and after staining for light and electron microscopy, they were semiquantitatively examined for several parameters: cellularity, myeloid:erythroid (M:E) ratio, megakaryocytes, fatty tissue, megaloblasts, and marrow iron [5].
  • Biosynthesis of predominantly arginine-rich histones in megaloblastic bone marrows was markedly reduced as compared to normoblastic bone marrows, which was consistently associated with elongation and despiralization of chromosomes and finely stippled nuclear chromatin in megaloblasts [6].

Anatomical context of Megaloblasts


Associations of Megaloblasts with chemical compounds


  1. Detection of methionine in pernicious anemia megaloblasts and other types of erythroid precursors. Kass, L. Am. J. Clin. Pathol. (1976) [Pubmed]
  2. Erythroid Fc-IgG and complement receptor expression: a study of normoblastic and megaloblastic human bone marrows. Bynoe, A.G., Scott, C.S., Roberts, B.E. Blood (1982) [Pubmed]
  3. HLA expression in hemopoietic development. Class I and II antigens are induced in the definitive erythroid lineage and differentially modulated by fetal liver cytokines. Gabbianelli, M., Boccoli, G., Cianetti, L., Russo, G., Testa, U., Peschle, C. J. Immunol. (1990) [Pubmed]
  4. Reversal of ineffective erythropoiesis in pernicious anaemia following vitamin B12 therapy. Samson, D., Halliday, D., Chanarin, I. Br. J. Haematol. (1977) [Pubmed]
  5. How erythropoietin affects bone marrow of uremic patients. Sikole, A., Stojanovic, A., Polenakovic, M., Petrusevska, G., Sadikario, S., Saso, R., Jovanovski, M. American journal of nephrology. (1997) [Pubmed]
  6. Megaloblastosis: from morphos to molecules. Das, K.C., Das, M., Mohanty, D., Jadaon, M.M., Gupta, A., Marouf, R., Easow, S.K. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. (2005) [Pubmed]
  7. Erythremia with special reference to sideroblastic anemia. Taki, T., Wakabayashi, T., Kishimoto, H. Acta Pathol. Jpn. (1980) [Pubmed]
  8. Iron and folate status in Gambian children with malaria. Abdalla, S.H. Annals of tropical paediatrics. (1990) [Pubmed]
  9. Morphology, biology and biochemistry of cobalamin- and folate-deficient bone marrow cells. Wickramasinghe, S.N. Baillieres Clin. Haematol. (1995) [Pubmed]
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