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Chemical Compound Review

MDEA     1-benzo[1,3]dioxol-5-yl-N- ethyl-propan-2...

Synonyms: N-MDE, N-Ethyl-mda, N-Ethyl MDA, CHEMBL126279, SureCN715096, ...
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Disease relevance of N-Ethyl-mda


Psychiatry related information on N-Ethyl-mda


High impact information on N-Ethyl-mda


Biological context of N-Ethyl-mda

  • The cause and manner of death of these seven cases were: 3,4-methylenedioxy-N-methamphetamine (MDMA) and 3,4-methylenedioxy-N-ethylamphetamine (MDEA) poisoning (n = 1), drowning in water (n = 4), cranial injuries caused by a traffic accident (n = 1) and heart failure (n = 1) [7].

Associations of N-Ethyl-mda with other chemical compounds


Gene context of N-Ethyl-mda

  • Administration of a single dose of the recreationally used drug 3,4-methylenedioxyethamphetamine (MDEA or "eve") to Dark Agouti rats resulted in an acute dose-dependent hyperthermic response [10].
  • The consumption of N-ethyl-3,4-methylenedioxyamphetamine (MDE, 1), an analogue of ecstasy, can be detected by direct in situ HPTLC-FTIR measurement of the main metabolite N-ethyl-4-hydroxy-3-methoxyamphetamine (HME, 2) [12].

Analytical, diagnostic and therapeutic context of N-Ethyl-mda


  1. Hyperthermia associated with 3,4-methylenedioxyethamphetamine ('Eve'). Tehan, B., Hardern, R., Bodenham, A. Anaesthesia. (1993) [Pubmed]
  2. Effects of MDMA, MDA and MDEA on blood pressure, heart rate, locomotor activity and body temperature in the rat involve alpha-adrenoceptors. Bexis, S., Docherty, J.R. Br. J. Pharmacol. (2006) [Pubmed]
  3. Determination of the designer drugs 3, 4-methylenedioxymethamphetamine, 3,4-methylenedioxyethylamphetamine, and 3,4-methylenedioxyamphetamine with HPLC and fluorescence detection in whole blood, serum, vitreous humor, and urine. Clauwaert, K.M., Van Bocxlaer, J.F., De Letter, E.A., Van Calenbergh, S., Lambert, W.E., De Leenheer, A.P. Clin. Chem. (2000) [Pubmed]
  4. The content of ecstasy tablets: implications for the study of their long-term effects. Cole, J.C., Bailey, M., Sumnall, H.R., Wagstaff, G.F., King, L.A. Addiction (2002) [Pubmed]
  5. L-DOPA potentiation of the serotonergic deficits due to a single administration of 3,4-methylenedioxymethamphetamine, p-chloroamphetamine or methamphetamine to rats. Schmidt, C.J., Black, C.K., Taylor, V.L. Eur. J. Pharmacol. (1991) [Pubmed]
  6. A comparison of the neurotoxic potential of methylenedioxyamphetamine (MDA) and its N-methylated and N-ethylated derivatives. Stone, D.M., Johnson, M., Hanson, G.R., Gibb, J.W. Eur. J. Pharmacol. (1987) [Pubmed]
  7. Amphetamine derivative related deaths in northern Greece. Raikos, N., Tsoukali, H., Psaroulis, D., Vassiliadis, N., Tsoungas, M., Njau, S.N. Forensic Sci. Int. (2002) [Pubmed]
  8. Effects of the hallucinogen psilocybin on covert orienting of visual attention in humans. Gouzoulis-Mayfrank, E., Thelen, B., Maier, S., Heekeren, K., Kovar, K.A., Sass, H., Spitzer, M. Neuropsychobiology (2002) [Pubmed]
  9. Development and validation of a gas chromatography-mass spectrometry assay for hair analysis of amphetamine, methamphetamine and methylenedioxy derivatives. Pujadas, M., Pichini, S., Poudevida, S., Menoyo, E., Zuccaro, P., Farré, M., de la Torre, R. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2003) [Pubmed]
  10. The acute effect in rats of 3,4-methylenedioxyethamphetamine (MDEA, "eve") on body temperature and long term degeneration of 5-HT neurones in brain: a comparison with MDMA ("ecstasy"). Colado, M.I., Granados, R., O'Shea, E., Esteban, B., Green, A.R. Pharmacol. Toxicol. (1999) [Pubmed]
  11. Hair analysis: self-reported use of "speed" and "ecstasy" compared with laboratory findings. Cooper, G.A., Allen, D.L., Scott, K.S., Oliver, J.S., Ditton, J., Smith, I.D. J. Forensic Sci. (2000) [Pubmed]
  12. High-performance thin-layer chromatographic determination of N-ethyl-3,4-methylenedioxyamphetamine and its major metabolites in urine and comparison with high-performance liquid chromatography. Pisternick, W., Kovar, K.A., Ensslin, H. J. Chromatogr. B Biomed. Sci. Appl. (1997) [Pubmed]
  13. Sleep EEG effects of 3,4-methylenedioxyethamphetamine (MDE; "eve") in healthy volunteers. Gouzoulis, E., Steiger, A., Ensslin, M., Kovar, A., Hermle, L. Biol. Psychiatry (1992) [Pubmed]
  14. Toxicological detection of the designer drug 3,4-methylenedioxyethylamphetamine (MDE, "Eve") and its metabolites in urine by gas chromatography-mass spectrometry and fluorescence polarization immunoassay. Ensslin, H.K., Kovar, K.A., Maurer, H.H. J. Chromatogr. B, Biomed. Appl. (1996) [Pubmed]
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