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Chemical Compound Review

AC1L1XG1     (3S)-2-amino-3-hydroxy-3- phenyl-propanoic...

Synonyms: A26752, (3R)-2-amino-3-hydroxy-3-phenylpropanoic acid
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Disease relevance of m-Tyrosine

  • This phenomenon has been investigated in two patients with phenylketonuria using the putative precursor L-m-tyrosine labelled with deuterium [1].
  • For the electrophilic preparation of 6-[18F]fluoro-L-m-tyrosine ([18F]FMT), a PET tracer for measuring changes in dopaminergic function in movement disorders, a novel precursor, N-(tert-butoxycarbonyl)-3-(tert-butoxycarbonyloxy)-6-trimethylstannnyl-L-phenylalanine ethyl ester, was synthesized in four steps and 26% yield starting from L-m-tyrosine [2].

High impact information on m-Tyrosine


Anatomical context of m-Tyrosine


Associations of m-Tyrosine with other chemical compounds


Analytical, diagnostic and therapeutic context of m-Tyrosine


  1. The metabolism of L-m-tyrosine: the use of a putative precursor to investigate the increased production of m-hydroxymandelic acid in phenylketonuria. Hoskins, J.A., Greenway, A.M. Clin. Chim. Acta (1983) [Pubmed]
  2. A new precursor for the preparation of 6-[18F]Fluoro-L-m-tyrosine ([18F]FMT): efficient synthesis and comparison of radiolabeling. VanBrocklin, H.F., Blagoev, M., Hoepping, A., O'Neil, J.P., Klose, M., Schubiger, P.A., Ametamey, S. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. (2004) [Pubmed]
  3. Decarboxylation-dependent transamination catalyzed by mammalian 3,4-dihydroxyphenylalanine decarboxylase. O'Leary, M.H., Baughn, R.L. J. Biol. Chem. (1977) [Pubmed]
  4. Radiofluorinated L-m-tyrosines: new in-vivo probes for central dopamine biochemistry. Barrio, J.R., Huang, S.C., Yu, D.C., Melega, W.P., Quintana, J., Cherry, S.R., Jacobson, A., Namavari, M., Satyamurthy, N., Phelps, M.E. J. Cereb. Blood Flow Metab. (1996) [Pubmed]
  5. Ortho- and meta-tyrosine formation from phenylalanine in human saliva as a marker of hydroxyl radical generation during betel quid chewing. Nair, U.J., Nair, J., Friesen, M.D., Bartsch, H., Ohshima, H. Carcinogenesis (1995) [Pubmed]
  6. Decarboxylation of p-tyrosine: a potential source of p-tyramine in mammalian tissues. Bowsher, R.R., Henry, D.P. J. Neurochem. (1983) [Pubmed]
  7. Measurement of o- and m-tyrosine as markers of oxidative damage in motor neuron disease. Poljak, A., Pamphlett, R., Gurney, M.E., Duncan, M.W. Redox Rep. (2000) [Pubmed]
  8. Studies on the depletion of brain amines by m-tyrosine. Smyth, R.G., Tong, J.H., D'Iorio, A. Eur. J. Pharmacol. (1977) [Pubmed]
  9. Compartmental analysis of dopa decarboxylation in living brain from dynamic positron emission tomograms. Cumming, P., Gjedde, A. Synapse (1998) [Pubmed]
  10. Involvement of biogenic amines with the mechanisms of novel analgesics. Vonvoigtlander, P.F., Lewis, R.A., Neff, G.L., Triezenberg, H.J. Prog. Neuropsychopharmacol. Biol. Psychiatry (1983) [Pubmed]
  11. Cerebral decarboxylation of meta- and para-tyrosine. Boulton, A.A., Juorio, A.V. Experientia (1983) [Pubmed]
  12. Aromatic-L-amino-acid decarboxylase activity in mouse pancreatic islets. Lindström, P. Biochim. Biophys. Acta (1986) [Pubmed]
  13. Assay for L-p-tyrosine in plasma and brain by column liquid chromatography with electrochemical detection using m-tyrosine as the internal standard. Edwards, D.J., Sorisio, D., Knopf, S., Mujumdar, S. J. Chromatogr. (1986) [Pubmed]
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