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Chemical Compound Review

Galsgal     (2R,3R,4S,5R,6S)-2- (hydroxymethyl)-6-[(2S...

Synonyms: GBTGP, CHEMBL52011, SureCN5520730, Tdg cpd, CHEBI:177098, ...
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Disease relevance of Thiodigalactoside


High impact information on Thiodigalactoside


Biological context of Thiodigalactoside


Anatomical context of Thiodigalactoside


Associations of Thiodigalactoside with other chemical compounds

  • Reactions were essentially enthalpically driven with the binding enthalpies ranging from -53.8 kJ/mol for thiodigalactoside at 301 K to -2.2 kJ/mol for galactose at 300 K, indicating that hydrogen-bonding and van der Waals interactions provide the major stabilization for these reactions [12].
  • The early heart anlagen of Xenopus laevis embryos were exposed to purified embryonic galactoside-binding lectin or its potent hapten inhibitor thiodigalactoside (TDG) [13].

Gene context of Thiodigalactoside


Analytical, diagnostic and therapeutic context of Thiodigalactoside


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  5. An analysis of lactose permease "sugar specificity" mutations which also affect the coupling between proton and lactose transport. II. Second site revertants of the thiodigalactoside-dependent proton leak by the Val177/Asn319 permease. Eelkema, J.A., O'Donnell, M.A., Brooker, R.J. J. Biol. Chem. (1991) [Pubmed]
  6. A lectin which binds specifically to beta-D-galactoside groups is present at the earliest stages of chick embryo development. Cook, G.M., Zalik, S.E., Milos, N., Scott, V. J. Cell. Sci. (1979) [Pubmed]
  7. The large subunit of herpes simplex virus type 1 ribonucleotide reductase: expression in Escherichia coli and purification. Furlong, J., Conner, J., McLauchlan, J., Lankinen, H., Galt, C., Marsden, H.S., Clements, J.B. Virology (1991) [Pubmed]
  8. The effect of galectin 1 on 3T3 cell proliferation on chitosan membranes. Chang, Y.Y., Chen, S.J., Liang, H.C., Sung, H.W., Lin, C.C., Huang, R.N. Biomaterials (2004) [Pubmed]
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  10. Mechanisms of adhesion among cells of the early chick blastoderm: role of the beta-D-galactoside-binding lectin in the adhesion of extraembryonic endoderm cells. Milos, N., Zalik, S.E. Differentiation (1982) [Pubmed]
  11. Involvement of endogenous galactoside-binding lectin of Xenopus laevis in pattern formation of Xenopus neurites in vitro. Milos, N.C., Ma, Y.L., Frunchak, Y.N. Cell Differ. Dev. (1989) [Pubmed]
  12. Energetics of carbohydrate binding by a 14 kDa S-type mammalian lectin. Ramkumar, R., Surolia, A., Podder, S.K. Biochem. J. (1995) [Pubmed]
  13. Alterations of heart development in Xenopus laevis by galactoside-binding lectin or its sugar hapten inhibitor. Frunchak, Y.N., Martha, G.N., McFadden, K.D., Milos, N.C. Anat. Embryol. (1993) [Pubmed]
  14. Binding specificity of a human leucocyte carbohydrate-binding protein. Allen, H.J. Immunol. Invest. (1986) [Pubmed]
  15. Defective development of the craniofacial/digestive complex of Xenopus laevis after treatment with endogenous galactoside-binding lectin or its hapten inhibitor thiodigalactoside. Varma, P.V., Frunchak, Y.N., Evanson, J.E., Milos, N.C. J. Craniofac. Genet. Dev. Biol. (1994) [Pubmed]
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