Disease relevance of Furro L

• The flame retardant tris(2,3-dibromopropyl)phosphate (Tris-BP) and the hair-dye component 2,4-diaminoanisole (2,4-DAA) were studied by possible cytotoxic effects in rat hepatoma cells grown in culture and in suspensions of isolated rat hepatocytes [1].

High impact information on Furro L

• A polychlorinated biphenyl mixture of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) given to rats greatly raised the specific activity (revertant TA98 colonies/mg S9 protein) of the mammary tissue using 2-AA as a test carcinogen, and permitted detection of 2,4-diaminoanisole (DAA) and 2,7-diaminofluorene (DAF) activation [2].
• Metabolic activation of 2,4-diaminoanisole, a hair-dye component--III. Role of cytochrome P-450 metabolism in irreversible binding in vivo [3].
• Carcinogenic 4-methoxy-m-phenylenediamine caused DNA damage at thymine and cytosine residues in the presence of Cu(II) [4].
• Catalase and bathocuproine, a Cu(I)-specific chelator, inhibited 4-methoxy-m-phenylenediamine-induced DNA damage, suggesting the involvement of H2O2 and Cu(I) [4].
• In the presence of ram seminal vesicle microsomes and arachidonic acid, DNA strand breaks were induced by 2-naphthylamine, 2,4-diaminotoluene and 4-methoxy-m-phenylenediamine [5].

Biological context of Furro L

• There is a sex difference in the inducing effects of HCB on ethylmorphine N-demethylase, but not on 2,4-diaminoanisole mutagenicity [6].

Anatomical context of Furro L

• 2,4-Diaminoanisole itself was mutagenic only in the presence of an activating system. alpha-Naphthoflavone (ANF) (0.1 mM) inhibited by 85--90% the in vitro mutagenicity of urine, mediated by Aroclor 1254, MC or TCDD induced rat-liver microsomes [7].
• The effect of the carcinogenic hair dye component 2,4-diaminoanisole (2,4-DAA) on thyroid and pituitary morphology was studied [8].

Associations of Furro L with other chemical compounds

• Promoting effect of 2,4-diaminoanisole sulfate on rat thyroid carcinogenesis [9].
• 2,4-diaminoanisole-induced thyroid pigmentation in rats inhibited by m-phenylenediamine [8].
• Hexachlorobenzene induction of 2,4-diaminoanisole mutagenicity in vitro [6].
• Carcinogenic effect of combined administration of 2,4-diaminoanisole sulfate, 4,4'-thiodianiline and N,N'-diethylthiourea in male Wistar rats [10].

Gene context of Furro L

• Rats of group 1 were fed basal powdered diet containing 610 ppm 2,4- diaminoanisole sulfate (DAAS), 46 ppm 4,4'-thiodianiline (TDA) and 200 ppm N,N'-diethylthiourea (DETU) for 52 weeks (DTD treatment) [10].

References