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Chemical Compound Review

SGCUT00106     2,6-dichloro-4-nitro-phenol

Synonyms: SureCN887770, NSC-4123, ACMC-1B2B6, AG-G-26230, ANW-33972, ...
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Disease relevance of NSC4123


High impact information on NSC4123

  • The propensity of these N-hydroxy arylamines and N-hydroxy heterocyclic amines to serve as selective substrates for human TS-PST was further confirmed by inhibition with 2,6-dichloro-4-nitrophenol and by thermostability studies [2].
  • The transfected cells expressed a high level of DHEA ST activity, and this enzyme activity displayed a pattern of inhibition by the ST inhibitor 2,6-dichloro-4-nitrophenol identical to that of human liver DHEA ST [3].
  • N-OH-FAABP was a substrate for sulfotransferases in vitro and sulfation was inhibited by the sulfotransferase inhibitors pentachlorophenol (PCP) and 2,6-dichloro-4-nitrophenol (DCNP) [4].
  • [35S]PAPS formation in slices was completely and rather potently blocked by 2,6-dichloro-4-nitrophenol (IC50 = 10 microM), an inhibitor of the PAPS-synthesizing enzyme system in a cytosolic preparation [5].
  • Several biochemical properties of each enzyme that included apparent K(m) values, thermal stabilities, and responses to the inhibitors 2,6-dichloro-4-nitrophenol and NaCl were used to further characterize the SULT activities [6].

Biological context of NSC4123


Anatomical context of NSC4123


Associations of NSC4123 with other chemical compounds


Gene context of NSC4123

  • Our results demonstrated 2 forms of the pituitary enzyme that were similar to the thermostable (TS) and thermolabile (TL) forms of platelet PST with regard to assay conditions, pH optima, Km values for multiple substrates, responses to 2,6-dichloro-4-nitrophenol (DCNP), and thermal stability properties [18].
  • Human liver arylamine N-sulfotransferase (AANST) activity was similar to that of TS but not TL PST with regard to thermal stability, inhibition by 2,6-dichloro-4-nitrophenol (DCNP), and regulation among individuals [19].
  • Biochemical properties of each skin enzyme were the same as the platelet enzymes with respect to apparent Km values for substrates, pH optima, thermal stabilities and responses to inhibition by 2,6-dichloro-4-nitrophenol (DCNP) [20].
  • Since 2,6-dichloro-4-nitrophenol (DCNP) produces a prolonged and selective inhibition of the sulfoconjugation of exogenous phenols by the liver, we decided to examine the applicability of DCNP to studies of sulfation of CCK-8 and other compounds by brain [21].
  • H-PST was sensitive to inhibition by DCNP (2,6-dichloro-4-nitrophenol) [22].

Analytical, diagnostic and therapeutic context of NSC4123


  1. Cholestatic effect of harmol glucuronide in the rat. Prevention of harmol-induced cholestasis by increased formation of harmol sulfate. Krijgsheld, K.R., Koster, H.J., Scholtens, E., Mulder, G.J. J. Pharmacol. Exp. Ther. (1982) [Pubmed]
  2. Metabolic activation of N-hydroxy arylamines and N-hydroxy heterocyclic amines by human sulfotransferase(s). Chou, H.C., Lang, N.P., Kadlubar, F.F. Cancer Res. (1995) [Pubmed]
  3. Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA. Otterness, D.M., Wieben, E.D., Wood, T.C., Watson, W.G., Madden, B.J., McCormick, D.J., Weinshilboum, R.M. Mol. Pharmacol. (1992) [Pubmed]
  4. The role of sulfation in the metabolic activation of N-hydroxy-4'-fluoro-4-acetylaminobiphenyl. van de Poll, M.L., Tijdens, R.B., Vondrácek, P., Bruins, A.P., Meijer, D.K., Meerman, J.H. Carcinogenesis (1989) [Pubmed]
  5. Formation and utilization of the active sulfate donor [35S]3'-phosphoadenosine 5'-phosphosulfate in brain slices: effects of depolarizing agents. Gulat-Marnay, C., Lafitte, A., Vargas, F., Schwartz, J.C. J. Neurochem. (1987) [Pubmed]
  6. Thermostable (SULT1A1) and thermolabile (SULT1A3) phenol sulfotransferases in human osteosarcoma and osteoblast cells. Dubin, R.L., Hall, C.M., Pileri, C.L., Kudlacek, P.E., Li, X.Y., Yee, J.A., Johnson, M.L., Anderson, R.J. Bone (2001) [Pubmed]
  7. Selective inhibition of sulfate conjugation in the rat: pharmacokinetics and characterization of the inhibitory effect of 2,6-dichloro-4-nitrophenol. Koster, H., Halsema, I., Scholtens, E., Meerman, J.H., Pang, K.S., Mulder, G.J. Biochem. Pharmacol. (1982) [Pubmed]
  8. In-vivo activation of N-nitrosodiethanolamine and other n-nitroso-2-hydroxyalkylamines by alcohol dehydrogenase and sulfotransferase. Denkel, E., Sterzel, W., Eisenbrand, G. IARC Sci. Publ. (1987) [Pubmed]
  9. Suicidal differential housekeeping gene activity in apoptosis induced by DCNP. Qi, L., Sit, K.H. Apoptosis (2000) [Pubmed]
  10. The contribution of N-oxidation to the metabolism of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in rat hepatocytes. Turesky, R.J., Bracco-Hammer, I., Markovic, J., Richli, U., Kappeler, A.M., Welti, D.H. Chem. Res. Toxicol. (1990) [Pubmed]
  11. In vitro activation of 2-aminobenzyl alcohol and 2-amino-6-nitrobenzyl alcohol, metabolites of 2-nitrotoluene and 2,6-dinitrotoluene. Chism, J.P., Rickert, D.E. Chem. Res. Toxicol. (1989) [Pubmed]
  12. Localization of human blood phenol sulfotransferase activities: novel detection of the thermostable enzyme in granulocytes. Anderson, R.J., Garcia, M.J., Liebentritt, D.K., Kay, H.D. J. Lab. Clin. Med. (1991) [Pubmed]
  13. 1-Naphthol metabolism and metabolite transport in the small and large intestine. II: Effect of sulphate and phosphate ion omission, and of 2,6-dichloro-4-nitrophenol in the isolated guinea pig mucosa. Sund, R.B., Lauterbach, F. Pharmacol. Toxicol. (1987) [Pubmed]
  14. Activation of the liver carcinogen 2-nitropropane by aryl sulfotransferase. Sodum, R.S., Sohn, O.S., Nie, G., Fiala, E.S. Chem. Res. Toxicol. (1994) [Pubmed]
  15. Relationship between sulfotransferase activity and susceptibility to acetaminophen-induced liver necrosis in the hamster. Miller, M.G., Jollow, D.J. Drug Metab. Dispos. (1987) [Pubmed]
  16. Flavonoids, potent inhibitors of the human P-form phenolsulfotransferase. Potential role in drug metabolism and chemoprevention. Eaton, E.A., Walle, U.K., Lewis, A.J., Hudson, T., Wilson, A.A., Walle, T. Drug Metab. Dispos. (1996) [Pubmed]
  17. Effect of sulfation substrates/inhibitors on N-(3,5-dichlorophenyl)succinimide nephrotoxocity in Fischer 344 rats. Hong, S.K., Anestis, D.K., Kennedy, S., Rankin, G.O. J. Toxicol. Environ. Health Part A (1999) [Pubmed]
  18. Human pituitary phenol sulfotransferase: biochemical properties and activities of the thermostable and thermolabile forms. Anderson, R.J., Yoon, J.K., Sinsheimer, E.G., Jackson, B.L. Neuroendocrinology (1986) [Pubmed]
  19. Human liver arylamine N-sulfotransferase activity. Thermostable phenol sulfotransferase catalyzes the N-sulfation of 2-naphthylamine. Hernández, J.S., Powers, S.P., Weinshilboum, R.M. Drug Metab. Dispos. (1991) [Pubmed]
  20. Human skin and platelet minoxidil sulfotransferase activities: biochemical properties, correlations and contribution of thermolabile phenol sulfotransferase. Kudlacek, P.E., Anderson, R.J., Liebentritt, D.K., Johnson, G.A., Huerter, C.J. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  21. Sulfation of peptides and simple phenols by rat brain phenolsulfotransferase. Inhibition by dichloronitrophenol. Giorgi, O., Meek, J.L. Biochem. Pharmacol. (1985) [Pubmed]
  22. High level expression and characterization of recombinant human hippocampus phenol sulfotransferase: a novel phenol-sulfating form of phenol sulfotransferase. Hwang, S.R., Palkovits, M., Hook, V.Y. Protein Expr. Purif. (1997) [Pubmed]
  23. Cooperative ligand binding by bovine phenol sulfotransferase. Beckmann, J.D., Henry, T., Ulphani, J., Lee, P. Chem. Biol. Interact. (1998) [Pubmed]
  24. Nonlinear protein binding and enzyme heterogeneity: effects on hepatic drug removal. Xu, X., Selick, P., Pang, K.S. Journal of pharmacokinetics and biopharmaceutics. (1993) [Pubmed]
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