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Chemical Compound Review

Amidosal     2-hydroxybenzamide

Synonyms: Dolomide, Panithal, Salamide, Saliamid, Saliamin, ...
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Disease relevance of Cetamide


High impact information on Cetamide


Chemical compound and disease context of Cetamide


Biological context of Cetamide


Anatomical context of Cetamide


Associations of Cetamide with other chemical compounds


Gene context of Cetamide

  • A photoaffinity probe, 2-(4-phosphopentamanniminophenyl)ethyl-(4-azido) salicylamide, was prepared for photolabelling of the mannose 6-phosphate/insulin-like growth factor II receptor [26].
  • By analysis of the metabolic profile of RB, and by inhibition of glucuronidation (the main metabolic route) with salicylamide, we show in this paper that formation and secretion of RB-conjugates from liver into perfusate is not involved in the reappearance and redistribution phenomena [27].
  • The total solubility of salicylamide increased nonlinearly at lower antihistamine concentrations (less than 0.4 M), but reached limiting linearity (slope = 0.34 mol/mol of antihistamine) at higher concentrations (up to 0.8 M) [28].
  • Following diethyl ether extraction, 4NC and the assay internal standard (salicylamide) were separated by reversed-phase (C18) liquid chromatography [29].
  • Sulfatase and beta-glucuronidase treatment allowed the analysis of plasma sulfate and glucuronide conjugates as free salicylamide [30].

Analytical, diagnostic and therapeutic context of Cetamide


  1. Enhanced bioavailability and decreased clearance of analgesics in patients with cirrhosis. Neal, E.A., Meffin, P.J., Gregory, P.B., Blaschke, T.F. Gastroenterology (1979) [Pubmed]
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  3. Potential salicylamide antiplaque agents: in vitro antibacterial activity against Actinomyces viscosus. Coburn, R.A., Batista, A.J., Evans, R.T., Genco, R.J. J. Med. Chem. (1981) [Pubmed]
  4. Salicylamide inhibitors of influenza virus fusion. Combrink, K.D., Gulgeze, H.B., Yu, K.L., Pearce, B.C., Trehan, A.K., Wei, J., Deshpande, M., Krystal, M., Torri, A., Luo, G., Cianci, C., Danetz, S., Tiley, L., Meanwell, N.A. Bioorg. Med. Chem. Lett. (2000) [Pubmed]
  5. Effect of salicylamide on the growth of a Morris hepatoma in rats fed 8% and 25% casein diets. Knight, E.M., Nzelibe, G., Criss, W. Drug-nutrient interactions. (1983) [Pubmed]
  6. The drug salicylamide is an antagonist of the aryl hydrocarbon receptor that inhibits signal transduction induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. MacDonald, C.J., Ciolino, H.P., Yeh, G.C. Cancer Res. (2004) [Pubmed]
  7. Binding of the respiratory chain inhibitor antimycin to the mitochondrial bc1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern. Huang, L.S., Cobessi, D., Tung, E.Y., Berry, E.A. J. Mol. Biol. (2005) [Pubmed]
  8. Tocainide kinetics and metabolism: effects of phenobarbital and substrates of glucuronyl transferase. Elvin, A.T., Lalka, D., Stoeckel, K., du Souich, P., Axelson, J.E., Golden, L.H., McLean, A.J. Clin. Pharmacol. Ther. (1980) [Pubmed]
  9. Rational design and synthesis of androgen receptor-targeted nonsteroidal anti-androgen ligands for the tumor-specific delivery of a doxorubicin-formaldehyde conjugate. Cogan, P.S., Koch, T.H. J. Med. Chem. (2003) [Pubmed]
  10. In vitro activity of nitazoxanide and related compounds against isolates of Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis. Adagu, I.S., Nolder, D., Warhurst, D.C., Rossignol, J.F. J. Antimicrob. Chemother. (2002) [Pubmed]
  11. Biotransformation and disposition of hexachlorocyclopentadiene in fish. Podowski, A.A., Sclove, S.L., Pilipowicz, A., Khan, M.A. Arch. Environ. Contam. Toxicol. (1991) [Pubmed]
  12. Salycylamide glucuronide formation in liver disease and its change by drugs. Adachi, Y., Wakisaka, G., Yamamoto, T. Gastroenterol. Jpn. (1975) [Pubmed]
  13. Difference in hepatic uptake kinetics of aspirin and salicylamide in rats. Iwamoto, K., Furune, Y., Watanabe, J. Biochem. Pharmacol. (1984) [Pubmed]
  14. Nonlinear intestinal first-pass metabolism of salicylamide in dogs after portacaval transposition. Pond, S.M., Waschek, J.A., Mahacha, V., Fielding, R.M., Effeney, D.J., Tozer, T.N. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  15. Effect of salicylamide on the placental transfer and fetal tissue distribution of sodium-35S-sulfate in the rat. Knight, E., Van Wart, J., Roe, D.A. J. Nutr. (1978) [Pubmed]
  16. Effect of route of administration on competitive drug biotransformation interaction: salicylamide-ascorbic acid interaction in rats. Houston, J.B., Levy, G. J. Pharmacol. Exp. Ther. (1976) [Pubmed]
  17. Determination of salicylamide and five metabolites in biological fluids by high-performance liquid chromatography. Morris, M.E., Levy, G. Journal of pharmaceutical sciences. (1983) [Pubmed]
  18. Demonstration of rapid entry and a cellular binding space for salicylamide in perfused rat liver: a multiple indicator dilution study. Pang, K.S., Barker, F., Schwab, A.J., Goresky, C.A. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  19. Extrahepatic extraction of salicylamide in dogs. Fielding, R.M., Waschek, J.A., Effeney, D.J., Pogany, A.C., Pond, S.M., Tozer, T.N. J. Pharmacol. Exp. Ther. (1986) [Pubmed]
  20. Effect of product inhibition on elimination kinetics of ethoxybenzamide in rabbits. Analysis by physiological pharmacokinetic model. Lin, J.H., Sugiyama, Y., Hanano, M., Awazu, S. Drug Metab. Dispos. (1984) [Pubmed]
  21. Vectorial release of sulfoconjugates in the vascularly perfused mouse small intestine. Wollenberg, P., Rummel, W. Biochem. Pharmacol. (1984) [Pubmed]
  22. Differentiating nonaqueous titration of aspirin, acetaminophen, and salicylamide mixtures. Rhodes, H.J., DeNardo, J.J., Bode, D.W., Blake, M.I. Journal of pharmaceutical sciences. (1975) [Pubmed]
  23. Inhibition by salicylamide of 7,12-dimethylbenz[a]anthracene-evoked DNA excision repair in isolated rat hepatocytes: an indication of the involvement of a sulfate ester intermediate in carcinogenesis? Brouns, R.M., Van Doorn, R., Bos, R.P., Henderson, P.T. Mutat. Res. (1980) [Pubmed]
  24. Preparation and evaluation of Eudragit gels. VI: In vivo evaluation of Eudispert rectal hydrogel and xerogel containing salicylamide. Umejima, H., Kim, N.S., Ito, T., Uchida, T., Goto, S. Journal of pharmaceutical sciences. (1993) [Pubmed]
  25. 3-Hydroxylation of salicylamide in mice. Howell, S.R., Kotkoskie, L.A., Dills, R.L., Klaassen, C.D. Journal of pharmaceutical sciences. (1988) [Pubmed]
  26. Preparation of a photoaffinity probe for the Man6P/IGF-II receptor. Miyagishima, T., Gasa, S., Honke, K., Miyazaki, T., Makita, A. Biol. Chem. Hoppe-Seyler (1993) [Pubmed]
  27. Zonal compartmentation of perfused rat liver: plasma reappearance of rhodamine B explained. Braakman, I., Groothuis, G.M., Meijer, D.K. J. Pharmacol. Exp. Ther. (1989) [Pubmed]
  28. Solubilization of salicylamide and acetaminophen by antihistamines in aqueous solution. Shah, S.P., Flanagan, D.R. Journal of pharmaceutical sciences. (1990) [Pubmed]
  29. High-performance liquid chromatographic assay for 4-nitrophenol hydroxylation, a putative cytochrome P-4502E1 activity, in human liver microsomes. Tassaneeyakul, W., Veronese, M.E., Birkett, D.J., Miners, J.O. J. Chromatogr. (1993) [Pubmed]
  30. Radiochemical plasma salicylamide assay using ring-labeled tritiated salicylamide. Stella, V.J., Varia, S.A., Riedy, M. Journal of pharmaceutical sciences. (1979) [Pubmed]
  31. Sodium salicylamide: relative bioavailability and subjective effects. Fleckenstein, L., Mundy, G.R., Horovitz, R.A., Mazzullo, J.M. Clin. Pharmacol. Ther. (1976) [Pubmed]
  32. Effects of aspirin-like drugs on mitogen-stimulated DNA synthesis of lymphocytes from pregnant rats and offspring. Millis, R.M., Ewii, M.C., Offiah, G.U., Hyde, B.P., Knight, E.M. Pediatr. Res. (1988) [Pubmed]
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