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Chemical Compound Review

SureCN483333     2,8-diamino-9-[(2R,3R,4S,5R)- 3,4-dihydroxy...

Synonyms: CHEMBL2021376, AC1L3XCR, AC1Q6MUD, KB-46630, CTK1C3634, ...
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Disease relevance of NSC 90390


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Chemical compound and disease context of NSC 90390


Biological context of NSC 90390


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Gene context of NSC 90390


Analytical, diagnostic and therapeutic context of NSC 90390

  • 8-Aminoguanosine, isolated from hydrolysates of liver RNA from 2-NP-treated rats, cochromatographed with synthetic or commercially-obtained standard on reverse-phase as well as cation-exchange HPLC, and its UV spectral characteristics at acidic, neutral, and basic pH were identical to those of the standard [17].
  • Furthermore, in four evaluable recipients, discontinuation of the 8-aminoguanosine while continuing platelet transfusions from their original donors did not result in refractoriness [18].
  • These data showed that the administration of 8-aminoguanosine to rats provided an animal model of NP deficiency that will allow studies of the specific regulation of T-cell function [11].
  • Modification of the drug schedule to early short-term administration of both deoxyguanosine and 8-aminoguanosine, followed by long-term intermittent doses of only 8-aminoguanosine, was not only well tolerated by all the animals but also resulted in significant immunosuppression [18].


  1. Inhibition of purine nucleoside phosphorylase by 8-aminoguanosine: selective toxicity for T lymphoblasts. Kazmers, I.S., Mitchell, B.S., Dadonna, P.E., Wotring, L.L., Townsend, L.B., Kelley, W.N. Science (1981) [Pubmed]
  2. 2'-deoxyguanosine toxicity for B and mature T lymphoid cell lines is mediated by guanine ribonucleotide accumulation. Sidi, Y., Mitchell, B.S. J. Clin. Invest. (1984) [Pubmed]
  3. Inhibitors of purine nucleoside phosphorylase: effects of 9-deazapurine ribonucleosides and synthesis of 5'-deoxy-5'-iodo-9-deazainosine. Stoeckler, J.D., Ryden, J.B., Parks, R.E., Chu, M.Y., Lim, M.I., Ren, W.Y., Klein, R.S. Cancer Res. (1986) [Pubmed]
  4. The effect of deoxyguanosine on human lymphocyte function. II. Analysis of the interference with B lymphocyte differentiation in vitro. Spaapen, L.J., Rijkers, G.T., Staal, G.E., Rijksen, G., Duran, M., Stoop, J.W., Zegers, B.J. J. Immunol. (1984) [Pubmed]
  5. Effects of 8-aminoguanosine on the toxicity of guanosine and deoxyguanosine for malignant and normal lymphoid cells. van der Kraan, P.M., van Zandvoort, P.M., De Abreu, R.A., Bakkeren, J.A. J. Leukoc. Biol. (1988) [Pubmed]
  6. Deoxyadenosine triphosphate as a mediator of deoxyguanosine toxicity in cultured T lymphoblasts. Mann, G.J., Fox, R.M. J. Clin. Invest. (1986) [Pubmed]
  7. Prolongation of skin graft survival in dogs treated with 8-aminoguanosine. Benear, J.B., Frederick, D., Townsend, L., Epstein, R.B. Transplantation (1986) [Pubmed]
  8. Effect of combinations of deoxyguanosine and 8-aminoguanosine with 2,3-dihydro-1H-imidazo[1,2-b]pyrazole on L1210 cell growth in culture. Sato, A., Bacon, P.E., Schneller, S.W., Cory, J.G. Biochem. Pharmacol. (1984) [Pubmed]
  9. A canine model of induced purine nucleoside phosphorylase deficiency. Osborne, W.R., Deeg, H.J., Slichter, S.J. Clin. Exp. Immunol. (1986) [Pubmed]
  10. Histological and immunological evaluation of gnotobiotic C3H/He mice following i.v. administration of 8-aminoguanosine and 2'deoxyguanosine. Herrmann, M.J., Bealmear, P.M., Epstein, J. Prog. Clin. Biol. Res. (1985) [Pubmed]
  11. A rat model of purine nucleoside phosphorylase deficiency. Osborne, W.R., Barton, R.W. Immunology (1986) [Pubmed]
  12. Differential cytotoxicity of deoxyguanosine and 8-aminoguanosine for human leukemic cell lines and normal bone marrow progenitor cells. de Fouw, N.J., Ma, D.D., Michalevicz, R., Gray, D.A., Hoffbrand, A.V. Hematological oncology. (1984) [Pubmed]
  13. 8-Hydroxyguanosine and 8-methoxyguanosine possess immunostimulating activity for B lymphocytes. Ahmad, A., Mond, J.J. Cell. Immunol. (1985) [Pubmed]
  14. Dipyridamole and 8-aminoguanosine inhibition of nucleoside metabolism in rat blood in vitro. Gilbertsen, R.B., Dong, M.K. Adv. Exp. Med. Biol. (1986) [Pubmed]
  15. Metabolism of deoxynucleosides by lymphocytes in long-term culture deficient in different purine enzymes. Simmonds, H.A., Goday, A., Morris, G.S., Brolsma, M.F. Biochem. Pharmacol. (1984) [Pubmed]
  16. Metabolic activation of 2,6-diaminopurine and 2,6-diaminopurine-2'-deoxyriboside to antitumor agents. Weckbecker, G., Cory, J.G. Adv. Enzyme Regul. (1989) [Pubmed]
  17. 8-Aminoguanine: a base modification produced in rat liver nucleic acids by the hepatocarcinogen 2-nitropropane. Sodum, R.S., Nie, G., Fiala, E.S. Chem. Res. Toxicol. (1993) [Pubmed]
  18. Inhibition of the enzyme purine nucleoside phosphorylase (PNP) reduces refractoriness to transfused platelets in a dog model. Slichter, S.J., Deeg, H.J., Osborne, W.R. Br. J. Haematol. (1990) [Pubmed]
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