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Chemical Compound Review:

Acetylpyridine 1-pyridin-2-ylethanone

Synonyms: PubChem13363, CHEMBL11945, SureCN55127, AGN-PC-00G6BY, SureCN149590, ...

Christenson, B. et al., Hamzeh, F.M. et al., Klaymann, D.L. et al., Fabian, M. et al., Klayman, D.L. et al., et al.

Jahng, Park, Yoo, Kim, Kim, Yang,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NSC15043

Antiviral activity of 2-acetylpyridine thiosemicarbazones against herpes simplex virus [1].
In vitro susceptibility of Neisseria gonorrhoeae to 2-acetylpyridine thiosemicarbazones [2].
We studied the effects of 2-acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (1110U81 or A1110U), a potent inhibitor of the ribonucleotide reductases encoded by herpes simplex virus types 1 and 2 and by varicella-zoster virus, against human cytomegalovirus (HCMV) replication in infected MRC-5 cells [3].
Structural chemistry and In vitro antitubercular activity of acetylpyridine benzoyl hydrazone and its copper complex against Mycobacterium smegmatis [4].
A number of N4-monosubstituted 2-acetylpyridine thiosemicarbazones produced highly significant reductions in days to healing and lesion score without producing untoward dermal toxicity [5].

High impact information on NSC15043

The redox states of the "peroxy" (P) and "ferryl" (F) intermediates formed during reoxidation of reduced bovine cytochrome c oxidase have been probed by reduction with both ferrocytochrome c and acetylpyridine NADH under anaerobic conditions using optical spectroscopy [6].
MICs of 20 2-acetylpyridine thiosemicarbazones and penicillin were determined for 25 clinical isolates of beta-lactamase-positive and beta-lactamase-negative Neisseria gonorrhoeae strains [2].
In vitro assessment of 2-acetylpyridine thiosemicarbazones against chloroquine-resistant Plasmodium falciparum [7].
The most effective antimalarial agents among the N4-monosubstituted 2-acetylpyridine thiosemicarbazones recently described by us have a cyclohexyl or a phenyl substituent and produce cures in Plasmodium berghei infected mice at a dose of 160 and 320 mg/kg, respectively [8].
Based on the 50% inhibitory concentration (IC50) data of the 12 compounds evaluated, two of the 2-acetylpyridine series and two in the 2-acetylfuran series showed better IC50 values in vitro when compared with the standard amoebicidal drug, metronidazole [9].

Chemical compound and disease context of NSC15043

N4-Monosubstituted and N4,N4-disubstituted thiosemicarbazones derived from 2-acetylpyridine, 2-acetyl-6-methylpyridine and 2-butyrylpyridine, and N4,N4-disubstituted selenosemicarbazones derived from 2-acetylpyridine were evaluated against leukemia P388 in the mouse [10].

Anatomical context of NSC15043

Disrupted mitochondria displayed low levels of an apparent oxaloacetate-forming malate dehydrogenase activity when NAD or acetylpyridine NAD served as the coenzyme [11].

Associations of NSC15043 with other chemical compounds

The compounds most active against the beta-lactamase-producing strains were the N4,N4-disubstituted derivatives and the thiosemicarbazone derivatives of the 2-acetylpyridines, followed by the other compounds related to the 2-acetylpyridine thiosemicarbazones [2].
A series of conformationally controlled 2-PAM derivatives were prepared from 2-acetylpyridine and 2,3-pyrido[b]cycloalkenones in two steps and their reactivities towards parathion poisoned AChE were evaluated [12].
NADP, NADPH, acetylpyridine NAD and deamino NAD did not activate nor did they compete with NAD [13].

References

Antiviral activity of 2-acetylpyridine thiosemicarbazones against herpes simplex virus. Shipman, C., Smith, S.H., Drach, J.C., Klayman, D.L. Antimicrob. Agents Chemother. (1981) [Pubmed]
In vitro susceptibility of Neisseria gonorrhoeae to 2-acetylpyridine thiosemicarbazones. Christenson, B., Rodríguez, J.R., Gorbea, H.F., Ramírez-Rond, C.H. Antimicrob. Agents Chemother. (1985) [Pubmed]
2-Acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (1110U81) potently inhibits human cytomegalovirus replication and potentiates the antiviral effects of ganciclovir. Hamzeh, F.M., Spector, T., Lietman, P.S. Antimicrob. Agents Chemother. (1993) [Pubmed]
Structural chemistry and In vitro antitubercular activity of acetylpyridine benzoyl hydrazone and its copper complex against Mycobacterium smegmatis. Patole, J., Sandbhor, U., Padhye, S., Deobagkar, D.N., Anson, C.E., Powell, A. Bioorg. Med. Chem. Lett. (2003) [Pubmed]
Thiosemicarbazones of 2-acetylpyridine, 2-acetylquinoline, 1-acetylisoquinoline, and related compounds as inhibitors of herpes simplex virus in vitro and in a cutaneous herpes guinea pig model. Shipman, C., Smith, S.H., Drach, J.C., Klayman, D.L. Antiviral Res. (1986) [Pubmed]
Redox state of peroxy and ferryl intermediates in cytochrome c oxidase catalysis. Fabian, M., Palmer, G. Biochemistry (1999) [Pubmed]
In vitro assessment of 2-acetylpyridine thiosemicarbazones against chloroquine-resistant Plasmodium falciparum. Lambros, C., Childs, G.E., Notsch, J.D., Scovill, J.P., Klayman, D.L., Davidson, D.E. Antimicrob. Agents Chemother. (1982) [Pubmed]
2-Acetylpyridine thiosemicarbazones. 2. N4,N4-Disubstituted derivatives as potential antimalarial agents. Klaymann, D.L., Scovill, J.P., Bartosevich, J.F., Mason, C.J. J. Med. Chem. (1979) [Pubmed]
Synthesis and antiamoebic activity of new oxime ether derivatives containing 2-acetylpyridine/2-acetylfuran. Abid, M., Husain, K., Azam, A. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
2-Acetylpyridine thiosemicarbazones. 6.2-Acetylpyridine and 2-butyrylpyridine thiosemicarbazones as antileukemic agents. Klayman, D.L., Scovill, J.P., Mason, C.J., Bartosevich, J.F., Bruce, J., Lin, A.J. Arzneimittel-Forschung. (1983) [Pubmed]
Coupling of "malic" enzyme and NADPH:NAD transhydrogenase in the energetics of Hymenolepis diminuta (Cestoda). McKelvey, J.R., Fioravanti, C.F. Comp. Biochem. Physiol., B (1984) [Pubmed]
Synthesis and biological activity of conformationally controlled 2-PAM derivatives. Jahng, Y., Park, J.G., Yoo, J.W., Kim, S.Y., Kim, T., Yang, J.H. Arch. Pharm. Res. (2000) [Pubmed]
Activation of human placental 5-pregnene-3,20-dione isomerase activity by pyridine nucleotides. Blomquist, C.H., Kotts, C.E., Hakanson, E.Y. J. Steroid Biochem. (1988) [Pubmed]

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