The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

oxaloacetate     2-oxobutanedioic acid

Synonyms: oxalacetate, oxosuccinate, Ketosuccinate, Oxaloethanoate, oxalacetic acid, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of oxalacetic acid


High impact information on oxalacetic acid


Chemical compound and disease context of oxalacetic acid


Biological context of oxalacetic acid


Anatomical context of oxalacetic acid


Associations of oxalacetic acid with other chemical compounds


Gene context of oxalacetic acid


Analytical, diagnostic and therapeutic context of oxalacetic acid


  1. Aspartate 203 of the oxaloacetate decarboxylase beta-subunit catalyses both the chemical and vectorial reaction of the Na+ pump. Di Berardino, M., Dimroth, P. EMBO J. (1996) [Pubmed]
  2. Transcarboxylase 5S structures: assembly and catalytic mechanism of a multienzyme complex subunit. Hall, P.R., Zheng, R., Antony, L., Pusztai-Carey, M., Carey, P.R., Yee, V.C. EMBO J. (2004) [Pubmed]
  3. Structural characterization of the rat malic enzyme gene. Morioka, H., Magnuson, M.A., Mitsuhashi, T., Song, M.K., Rall, J.E., Nikodem, V.M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  4. 2-Keto-4-hydroxyglutarate aldolase: purification and characterization of the homogeneous enzyme from bovine kidney. Dekker, E.E., Kitson, R.P. J. Biol. Chem. (1992) [Pubmed]
  5. Novel enzymic machinery for the metabolism of oxalacetate, phosphoenolpyruvate, and pyruvate in Pseudomonas citronellolis. O'Brien, R., Chuang, D.T., Taylor, B.L., Utter, M.F. J. Biol. Chem. (1977) [Pubmed]
  6. Synthesis, structure and activity of artificial, rationally designed catalytic polypeptides. Johnsson, K., Allemann, R.K., Widmer, H., Benner, S.A. Nature (1993) [Pubmed]
  7. A specific enzyme is not necessary for vanadate-induced oxidation of NADH. Vyskocil, F., Teisinger, J., Dlouhá, H. Nature (1980) [Pubmed]
  8. Transcarboxylase 12S crystal structure: hexamer assembly and substrate binding to a multienzyme core. Hall, P.R., Wang, Y.F., Rivera-Hainaj, R.E., Zheng, X., Pustai-Carey, M., Carey, P.R., Yee, V.C. EMBO J. (2003) [Pubmed]
  9. In vitro mutagenesis of Escherichia coli citrate synthase to clarify the locations of ligand binding sites. Anderson, D.H., Duckworth, H.W. J. Biol. Chem. (1988) [Pubmed]
  10. Sequence of the sodium ion pump methylmalonyl-CoA decarboxylase from Veillonella parvula. Huder, J.B., Dimroth, P. J. Biol. Chem. (1993) [Pubmed]
  11. Crystal structure of the dimeric phosphoenolpyruvate carboxykinase (PEPCK) from Trypanosoma cruzi at 2 A resolution. Trapani, S., Linss, J., Goldenberg, S., Fischer, H., Craievich, A.F., Oliva, G. J. Mol. Biol. (2001) [Pubmed]
  12. Pre-steady-state kinetics of Escherichia coli aspartate aminotransferase catalyzed reactions and thermodynamic aspects of its substrate specificity. Kuramitsu, S., Hiromi, K., Hayashi, H., Morino, Y., Kagamiyama, H. Biochemistry (1990) [Pubmed]
  13. Kinetic mechanism of Escherichia coli isocitrate dehydrogenase and its inhibition by glyoxylate and oxaloacetate. Nimmo, H.G. Biochem. J. (1986) [Pubmed]
  14. Regulation of the acetate operon in Escherichia coli: purification and functional characterization of the IclR repressor. Cortay, J.C., Nègre, D., Galinier, A., Duclos, B., Perrière, G., Cozzone, A.J. EMBO J. (1991) [Pubmed]
  15. Transport of tricarboxylic acid cycle intermediates by membrane vesicles from renal brush border. Kippen, I., Hirayama, B., Klinenberg, J.R., Wright, E.M. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  16. cDNA sequence and localization of polymorphic human cytosolic phosphoenolpyruvate carboxykinase gene (PCK1) to chromosome 20, band q13.31: PCK1 is not tightly linked to maturity-onset diabetes of the young. Stoffel, M., Xiang, K.S., Espinosa, R., Cox, N.J., Le Beau, M.M., Bell, G.I. Hum. Mol. Genet. (1993) [Pubmed]
  17. Extramitochondrial citrate synthase activity in bakers' yeast. Rickey, T.M., Lewin, A.S. Mol. Cell. Biol. (1986) [Pubmed]
  18. Model to examine pathways of carbon flux from lactate to glucose at the first branch point in gluconeogenesis. Blackard, W.G., Clore, J.N. J. Biol. Chem. (1988) [Pubmed]
  19. Increased permeability of mitochondria during Ca2+ release induced by t-butyl hydroperoxide or oxalacetate. the effect of ruthenium red. Beatrice, M.C., Stiers, D.L., Pfeiffer, D.R. J. Biol. Chem. (1982) [Pubmed]
  20. Stereochemistry and function of oxaloacetate keto-enol tautomerase. Johnson, J.D., Creighton, D.J., Lambert, M.R. J. Biol. Chem. (1986) [Pubmed]
  21. Reconstitution of sodium transport from purified oxaloacetate decarboxylase and phospholipid vesicles. Dimroth, P. J. Biol. Chem. (1981) [Pubmed]
  22. Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets. Further implication of cytosolic NADPH in insulin secretion. MacDonald, M.J. J. Biol. Chem. (1995) [Pubmed]
  23. The liver glucose-6-phosphatase of intact microsomes is inhibited and displays sigmoid kinetics in the presence of alpha-ketoglutarate-magnesium and oxaloacetate-magnesium chelates. Mithieux, G., Vega, F.V., Riou, J.P. J. Biol. Chem. (1990) [Pubmed]
  24. The 2-hydroxycarboxylate transporter family: physiology, structure, and mechanism. Sobczak, I., Lolkema, J.S. Microbiol. Mol. Biol. Rev. (2005) [Pubmed]
  25. The PEP-pyruvate-oxaloacetate node as the switch point for carbon flux distribution in bacteria. Sauer, U., Eikmanns, B.J. FEMS Microbiol. Rev. (2005) [Pubmed]
  26. Anion uniport in plant mitochondria is mediated by a Mg(2+)-insensitive inner membrane anion channel. Beavis, A.D., Vercesi, A.E. J. Biol. Chem. (1992) [Pubmed]
  27. Substrate channeling of oxalacetate in solid-state complexes of malate dehydrogenase and citrate synthase. Datta, A., Merz, J.M., Spivey, H.O. J. Biol. Chem. (1985) [Pubmed]
  28. Control of gluconeogenesis in rat liver cells. I. Kinetics of the individual enzymes and the effect of glucagon. Groen, A.K., Vervoorn, R.C., Van der Meer, R., Tager, J.M. J. Biol. Chem. (1983) [Pubmed]
  29. Regulation of mitochondrial malic enzyme synthesis in mouse brain. Bernstine, E.G., Koh, C., Lovelace, C.C. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  30. Molecular characterization of pyruvate carboxylase deficiency in two consanguineous families. Wexler, I.D., Kerr, D.S., Du, Y., Kaung, M.M., Stephenson, W., Lusk, M.M., Wappner, R.S., Higgins, J.J. Pediatr. Res. (1998) [Pubmed]
  31. First characterization of an archaeal GTP-dependent phosphoenolpyruvate carboxykinase from the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1. Fukuda, W., Fukui, T., Atomi, H., Imanaka, T. J. Bacteriol. (2004) [Pubmed]
  32. Recombinant expression, purification, and characterization of three isoenzymes of aspartate aminotransferase from Arabidopsis thaliana. Wilkie, S.E., Warren, M.J. Protein Expr. Purif. (1998) [Pubmed]
  33. Simple purification of highly active biotinylated P-glycoprotein: enantiomer-specific modulation of drug-stimulated ATPase activity. Julien, M., Kajiji, S., Kaback, R.H., Gros, P. Biochemistry (2000) [Pubmed]
  34. Mechanism of the reductive activation of succinate dehydrogenase. Ackrell, B.A., Kearney, E.B., Edmondson, D. J. Biol. Chem. (1975) [Pubmed]
  35. Structural basis for regulation in gram-negative bacterial citrate synthases. Duckworth, H.W., Anderson, D.H., Bell, A.W., Donald, L.J., Chu, A.L., Brayer, G.D. Biochem. Soc. Symp. (1987) [Pubmed]
  36. Nonezymatic formation of succinate in mitochondria under oxidative stress. Fedotcheva, N.I., Sokolov, A.P., Kondrashova, M.N. Free Radic. Biol. Med. (2006) [Pubmed]
  37. Nicotinamide-adenine dinucleotide-linked "malic" enzyme in flight muscle of the tse-tse fly (Glossina) and other insects. Hoek, J.B., Pearson, D.J., Olembo, N.K. Biochem. J. (1976) [Pubmed]
  38. Purification of the sodium transport enzyme oxaloacetate decarboxylase by affinity chromatography on avidin sepharose. Dimroth, P. FEBS Lett. (1982) [Pubmed]
WikiGenes - Universities