Disease relevance of Selenomethionine

• Toxicity of seleno-L-methionine, seleno-DL-methionine, high selenium wheat, and selenized yeast to mallard ducklings [1].

High impact information on Selenomethionine

• Human PCA cells (LNCaP, PC3, PC3-AR2, and PC3-M) were incubated with and without selenium (Seleno-DL-methionine, 150 microM) for 24, 48, and 72 h [2].
• Peroxynitrite, the reaction product of nitric oxide and superoxide, rapidly oxidizes DL-selenomethionine (MetSe) with overall second-order kinetics, first-order in peroxynitrite and first-order in MetSe [3].
• We developed a simplified laboratory food chain where we fed commercial feed laden with seleno-D,L-methionine (30 microg/g dry mass) to crickets (Acheta domestica) for 5-7 d [4].
• Earlier studies have compared toxicities and oxidative stress of Se as selenite to those of seleno-DL-methionine (DL) in mallards (Anas platyrhynchos) [5].
• At the tested concentrations, B16 cells showed a greater sensitivity to the toxic effects of sodium selenite and seleno-DL-cystine than pB16 cells, whereas no decrease of B16 and pB16 cell number was observed after incubation with sodium selenate or seleno-DL-methionine [6].

Chemical compound and disease context of Selenomethionine

• Comparative toxicity of selenium from seleno-DL-methionine, sodium selenate, and Astragalus bisulcatus in pigs [7].

Biological context of Selenomethionine

• The effect was small, but in view of the ability of seleno-DL-methionine to inhibit lipid peroxidation in membranes, the results suggest that oxidative damage is implicated in freezing injury [8].

Associations of Selenomethionine with other chemical compounds

• Incubation of platelets with 2 mumol/liter seleno-DL-methionine for 30 min at room temperature before equilibration with the protective additives improved the post-thaw uptake of 5-hydroxytryptamine and the percentage reversal in the hypotonic stress test [8].

Analytical, diagnostic and therapeutic context of Selenomethionine

• We found that water-soluble selenium compounds led to a similar maximum content in blood and serum, but seleno-dl-methionine had a higher affinity for the brain and, by gel filtration chromatography, for the higher mol-wt (25-100 K Da) fractions of serum protein, when compared with inorganic forms [9].
• The chiral speciation of DL-selenomethionine (DL-SeMet) by high-performance liquid chromatography (HPLC) with UV absorbance on the CLES column was studied [10].
• The sections were subjected to qualitative and quantitative evaluation using Image Pro Digital Analysis System. Data collected expressed in mean +/- SE and analyzed for statistical significance using analysis of variance [11].

References