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Chemical Compound Review

Selenocystine     2-amino-3-(2-amino-2- carboxy...

Synonyms: CCRIS 3971, ACMC-20akm6, CHEBI:28553, S1650_SIGMA, HMDB04122, ...
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Disease relevance of C05704


High impact information on C05704


Chemical compound and disease context of C05704


Biological context of C05704


Anatomical context of C05704


Associations of C05704 with other chemical compounds

  • After selenium supplementation, with either sodium selenite or selenocystine, we observed an increase in growth of P. falciparum only in with sodium selenite, whereas higher GPx activities were noted in parasites grown in media supplemented with both [18].
  • Isomorphous replacement of cystine with selenocystine in endothelin: oxidative refolding, biological and conformational properties of [Sec3,Sec11,Nle7]-endothelin-1 [19].
  • The selenium K-edge X-ray absorption spectra of selenomethionine, selenocysteine, selenocystine, and sulfo-selenocystine in solution are compared with the corresponding sulfur K-edge spectra of the sulfur analogues of these compounds [20].
  • Taken together, these results suggest that the accessible redox-active cysteine residues present in the PKC catalytic domain can react with certain specificity with redox-active selenocompounds such as selenite, selenocystine, and GSSeSG relative to other protein kinases tested [10].
  • Generally, CF sera showed lower values of total Se, Selenocystine (SeC), and cationic/neutral Se compounds compared to serum of healthy persons [21].

Gene context of C05704


Analytical, diagnostic and therapeutic context of C05704


  1. Toxicity and chemical form of selenium in the liver of mice orally administered selenocystine for 90 days. Hasegawa, T., Taniguchi, S., Mihara, M., Nakamuro, K., Sayato, Y. Arch. Toxicol. (1994) [Pubmed]
  2. Interactions of selenium and fluoride on growth, glycolysis and survival of Streptococcus mutans GS-5. Eisenberg, A.D., Curzon, M.E., Izaguirre-Fernàndez, E.J. Caries Res. (1990) [Pubmed]
  3. Biological potency of selenium from sodium selenite, selenomethionine, and selenocystine in the chick. Osman, M., Latshaw, J.D. Poult. Sci. (1976) [Pubmed]
  4. The transport systems for selenomethionine/methionine and selenocystine/cystine in Escherichia coli K-12 appear to be cooperative. Kull, F.J., Lindblow-Kull, C., Shrift, A. Membrane biochemistry. (1987) [Pubmed]
  5. Reduction of the ascorbyl free radical to ascorbate by thioredoxin reductase. May, J.M., Cobb, C.E., Mendiratta, S., Hill, K.E., Burk, R.F. J. Biol. Chem. (1998) [Pubmed]
  6. Human thioredoxin reductase directly reduces lipid hydroperoxides by NADPH and selenocystine strongly stimulates the reaction via catalytically generated selenols. Björnstedt, M., Hamberg, M., Kumar, S., Xue, J., Holmgren, A. J. Biol. Chem. (1995) [Pubmed]
  7. Selenium and the thioredoxin and glutaredoxin systems. Björnstedt, M., Kumar, S., Björkhem, L., Spyrou, G., Holmgren, A. Biomed. Environ. Sci. (1997) [Pubmed]
  8. Specific binding proteins for selenium in rat tissues. Sani, B.P., Woodard, J.L., Pierson, M.C., Allen, R.D. Carcinogenesis (1988) [Pubmed]
  9. Induction of the mitochondrial permeability transition by selenium compounds mediated by oxidation of the protein thiol groups and generation of the superoxide. Kim, T.S., Yun, B.Y., Kim, I.Y. Biochem. Pharmacol. (2003) [Pubmed]
  10. Cancer-preventive selenocompounds induce a specific redox modification of cysteine-rich regions in Ca(2+)-dependent isoenzymes of protein kinase C. Gopalakrishna, R., Gundimeda, U., Chen, Z.H. Arch. Biochem. Biophys. (1997) [Pubmed]
  11. Mechanisms of selenium methylation and toxicity in mice treated with selenocystine. Hasegawa, T., Mihara, M., Nakamuro, K., Sayato, Y. Arch. Toxicol. (1996) [Pubmed]
  12. Copper may interact with selenite extracellularly in cultured HT-29 cells. Zeng, H., Botnen, J.H. J. Nutr. Biochem. (2004) [Pubmed]
  13. Deposition of dietary organic and inorganic selenium in rat erythrocyte proteins. Beilstein, M.A., Whanger, P.D. J. Nutr. (1986) [Pubmed]
  14. Identification and metabolism of selenocysteine-glutathione selenenyl sulfide (CySeSG) in small intestine of mice orally exposed to selenocystine. Hasegawa, T., Okuno, T., Nakamuro, K., Sayato, Y. Arch. Toxicol. (1996) [Pubmed]
  15. Chemical form of selenium-containing metabolite in small intestine and liver of mice following orally administered selenocystine. Hasegawa, T., Mihara, M., Okuno, T., Nakamuro, K., Sayato, Y. Arch. Toxicol. (1995) [Pubmed]
  16. Effects of amino acid analogues on protein synthesis and degradation in isolated cells. Knowles, S.E., Ballard, F.J. Br. J. Nutr. (1978) [Pubmed]
  17. Selenium absorption by canine jejunum. Reasbeck, P.G., Barbezat, G.O., Weber, F.L., Robinson, M.F., Thomson, C.D. Dig. Dis. Sci. (1985) [Pubmed]
  18. Increase in glutathione peroxidase activity in malaria parasite after selenium supplementation. Gamain, B., Arnaud, J., Favier, A., Camus, D., Dive, D., Slomianny, C. Free Radic. Biol. Med. (1996) [Pubmed]
  19. Isomorphous replacement of cystine with selenocystine in endothelin: oxidative refolding, biological and conformational properties of [Sec3,Sec11,Nle7]-endothelin-1. Pegoraro, S., Fiori, S., Rudolph-Böhner, S., Watanabe, T.X., Moroder, L. J. Mol. Biol. (1998) [Pubmed]
  20. X-ray absorption spectroscopy of selenium-containing amino acids. Pickering, I.J., George, G.N., Van Fleet-Stalder, V., Chasteen, T.G., Prince, R.C. J. Biol. Inorg. Chem. (1999) [Pubmed]
  21. Selenium speciation in human serum of cystic fibrosis patients compared to serum from healthy persons. Michalke, B. Journal of chromatography. A. (2004) [Pubmed]
  22. Generation of reactive oxygen species from the reaction of selenium compounds with thiols and mammary tumor cells. Yan, L., Spallholz, J.E. Biochem. Pharmacol. (1993) [Pubmed]
  23. Chemopreventive activity of selenocysteine prodrugs against tobacco-derived nitrosamine (NNK) induced lung tumors in the A/J mouse. Li, L., Xie, Y., El-Sayed, W.M., Szakacs, J.G., Franklin, M.R., Roberts, J.C. J. Biochem. Mol. Toxicol. (2005) [Pubmed]
  24. Effect of selenium compounds on murine B16 melanoma cells and pigmented cloned pB16 cells. Siwek, B., Bahbouth, E., Serra, M.A., Sabbioni, E., de Pauw-Gillet, M.C., Bassleer, R. Arch. Toxicol. (1994) [Pubmed]
  25. A novel selenocystine-beta-cyclodextrin conjugate that acts as a glutathione peroxidase mimic. Ren, X., Liu, J., Luo, G., Zhang, Y., Luo, Y., Yan, G., Shen, J. Bioconjug. Chem. (2000) [Pubmed]
  26. Separation of selenium analogues of sulphur-containing amino acids by high-performance liquid chromatography and high-resolution gas chromatography. Janák, J., Billiet, H.A., Frank, J., Luyben, K.C., Husek, P. Journal of chromatography. A. (1994) [Pubmed]
  27. The major selenium-containing protein in human peripheral granulocytes. Liu, Q., Lauridsen, E., Clausen, J. Biological trace element research. (1999) [Pubmed]
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