The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Cefadyl     (6R,7S)-3-(acetyloxymethyl)- 8-oxo-7-(2...

Synonyms: Ambrocef, Cefaprin, Cefatrex, Cefapirin, Metricure, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of cephapirin


High impact information on cephapirin


Chemical compound and disease context of cephapirin


Biological context of cephapirin


Anatomical context of cephapirin


Associations of cephapirin with other chemical compounds


Gene context of cephapirin

  • There was no change in renal clearance of beta 2-microglobulin which excludes a general toxic effect on tubular reabsorption of endogenous substances caused by cephapirin [24].
  • During the first phase of the trial, interleukin-2 was administered to 159 cows at a dose of 1 mg per gland by intracisternal infusion immediately after 300 mg of cephapirin were administered [17].
  • The combination treatment with cephapirin and lactoferrin showed that there was a synergistic bactericidal effect against all of the E. coli strains tested [29].

Analytical, diagnostic and therapeutic context of cephapirin


  1. Structural determinants of substrate binding to Bacillus cereus metallo-beta-lactamase. Rasia, R.M., Vila, A.J. J. Biol. Chem. (2004) [Pubmed]
  2. Differential inactivation of cephapirin vs. cephalothin by penicillin-resistant strains of Staphylococcus aureus: a preliminary study. Wilkins, J., Leedom, J.M., Overturf, G.D., Baraff, L.J. J. Infect. Dis. (1978) [Pubmed]
  3. Comparative incidence of phlebitis due to buffered cephalothin, cephapirin, and cefamandole. Berger, S., Ernst, E.C., Barza, M. Antimicrob. Agents Chemother. (1976) [Pubmed]
  4. Determination of in vitro susceptibility of Mycobacterium tuberculosis to cephalosporins by radiometric and conventional methods. Heifets, L.B., Iseman, M.D., Cook, J.L., Lindholm-Levy, P.J., Drupa, I. Antimicrob. Agents Chemother. (1985) [Pubmed]
  5. A comparison of the penetration characteristics of cephapirin and cephalothin into right atrial appendage, muscle, fat, and pericardial fluid of pediatric patients undergoing open-heart operation. Green, E.R., Subramanian, S., Faden, H., Quintiliani, R., Nightingale, C.H. Ann. Thorac. Surg. (1981) [Pubmed]
  6. Anion-exchange extraction of cephapirin, cefotaxime, and cefoxitin from serum for liquid chromatography. Fasching, C.E., Peterson, L.R. Antimicrob. Agents Chemother. (1982) [Pubmed]
  7. Penetration of cephapirin and cephalothin into the right atrial appendage and pericardial fluid of patients undergoing open-heart surgery. Quintiliani, R., Klimek, J., Nightingale, C.H. J. Infect. Dis. (1979) [Pubmed]
  8. Comparative beta-lactamase resistance and antistaphylococcal activities of parenterally and orally administered cephalosporins. Farrar, W.E., O'Dell, N.M. J. Infect. Dis. (1978) [Pubmed]
  9. Comparative pharmacokinetics of cefamandole, cephapirin, and cephalothin in healthy subjects and effect of repeated dosing. Barza, M., Melethil, S., Berger, S., Ernst, E.C. Antimicrob. Agents Chemother. (1976) [Pubmed]
  10. Optimization of separation and migration behavior of cephalosporins in capillary zone electrophoresis. Lin, C.E., Chen, H.W., Lin, E.C., Lin, K.S., Huang, H.C. Journal of chromatography. A. (2000) [Pubmed]
  11. Surgical complications related to insertion of penile prostheses with emphasis on infection and cost. Goetz, A., Yu, V.L., O'Donnell, W.F. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America. (1988) [Pubmed]
  12. Use of antimicrobial susceptibility testing of bacterial pathogens isolated from the milk of dairy cows with clinical mastitis to predict response to treatment with cephapirin and oxytetracycline. Constable, P.D., Morin, D.E. J. Am. Vet. Med. Assoc. (2002) [Pubmed]
  13. The effect of a single administration of cephapirin or cloprostenol on the reproductive performance of dairy cows with subclinical endometritis. Kasimanickam, R., Duffield, T.F., Foster, R.A., Gartley, C.J., Leslie, K.E., Walton, J.S., Johnson, W.H. Theriogenology (2005) [Pubmed]
  14. Effects of bovine mammary secretion during the early nonlactating period and antibiotics on polymorphonuclear neutrophil function and morphology. Lintner, T.J., Eberhart, R.J. Am. J. Vet. Res. (1990) [Pubmed]
  15. Depletion of antibiotics from the mammary gland of goats. Long, P.E., Heavner, J.E., Ziv, G., Geleta, J.N., Nepote, K. J. Dairy Sci. (1984) [Pubmed]
  16. Comparative pharmacokinetics and metabolism of cephapirin in laboratory animals and humans. Cabana, B.E., van Harken, D.R., Hottendorf, G.H. Antimicrob. Agents Chemother. (1976) [Pubmed]
  17. Recombinant bovine interleukin-2 and dry cow therapy: efficacy to cure and prevent intramammary infections, safety, and effect on gestation. Erskine, R.J., Bartlett, P.C., Tavernier, S.R., Fowler, L.H., Walker, R.D., Seguin, J.H., Shuster, D. J. Dairy Sci. (1998) [Pubmed]
  18. Cost benefit analysis of lactation therapy with somatic cell counts as indications for treatment. McDermott, M.P., Erb, H.N., Natzke, R.P., Barnes, F.D., Bray, D. J. Dairy Sci. (1983) [Pubmed]
  19. Determination of milk and mammary tissue concentrations of ceftiofur after intramammary and intramuscular therapy. Owens, W.E., Xiang, Z.Y., Ray, C.H., Nickerson, S.C. J. Dairy Sci. (1990) [Pubmed]
  20. Pharmacokinetics and synovial fluid concentrations of cephapirin in calves with suppurative arthritis. Brown, M.P., Gronwall, R.R., Pattio, N., Poulos, P.W., Houston, A.E. Am. J. Vet. Res. (1991) [Pubmed]
  21. Pharmacokinetics of sodium cephapirin in lactating dairy cows. Prades, M., Brown, M.P., Gronwall, R., Miles, N.S. Am. J. Vet. Res. (1988) [Pubmed]
  22. Persistence of a Staphylococcus aureus small-colony variant under antibiotic pressure in vivo. Brouillette, E., Martinez, A., Boyll, B.J., Allen, N.E., Malouin, F. FEMS Immunol. Med. Microbiol. (2004) [Pubmed]
  23. Pharmacokinetics and body fluid and endometrial concentrations of cephapirin in mares. Brown, M.P., Gronwall, R.R., Houston, A.E. Am. J. Vet. Res. (1986) [Pubmed]
  24. Effect of cephapirin on tubular reabsorption of amino acids, uric acid and beta 2-microglobulin in man. Arvidsson, A., Alván, G., Borgå, O., Eklöf, R. British journal of clinical pharmacology. (1983) [Pubmed]
  25. Agarose gel electrophoretic detection of six beta-lactam antibiotic residues in milk. Cutting, J.H., Kiessling, W.M., Bond, F.L., McCarron, J.E., Kreuzer, K.S., Hurlbut, J.A., Sofos, J.N. Journal of AOAC International. (1995) [Pubmed]
  26. Prevalence of minor udder pathogens after intramammary dry treatment. Harmon, R.J., Crist, W.L., Hemken, R.W., Langlois, B.E. J. Dairy Sci. (1986) [Pubmed]
  27. In vitro and in vivo comparative evaluations of injectable cephalosporin derivatives and ampicillin. Gotô, S., Kuwahara, S. Chemotherapy. (1976) [Pubmed]
  28. Disposition kinetics and bioavailability of piperacillin and cephapirin in mares. el-Komy, A.A. DTW. Dtsch. Tierarztl. Wochenschr. (1995) [Pubmed]
  29. Enhancement of the activity of novobiocin against Escherichia coli by lactoferrin. Sanchez, M.S., Watts, J.L. J. Dairy Sci. (1999) [Pubmed]
  30. Anaphylactic reaction to cephapirin during spinal anesthesia. Barnett, A.S., Hirshman, C.A. Anesth. Analg. (1979) [Pubmed]
  31. Conversion of cephapirin to deacetylcephapirin in milk and tissues of treated animals. Moats, W.A., Anderson, K.L., Rushing, J.E., Buckley, S. J. Agric. Food Chem. (2000) [Pubmed]
  32. Mouse mastitis model of infection for antimicrobial compound efficacy studies against intracellular and extracellular forms of Staphylococcus aureus. Brouillette, E., Grondin, G., Lefebvre, C., Talbot, B.G., Malouin, F. Vet. Microbiol. (2004) [Pubmed]
  33. An assessment of the duration of cephapirin-induced coagulation abnormalities as measured by thromboelastography. Baeuerle, J.J., Mongan, P.D., Hosking, M.P. J. Cardiothorac. Vasc. Anesth. (1993) [Pubmed]
  34. Effects of prepartum intramammary antibiotic therapy on udder health, milk production, and reproductive performance in dairy heifers. Borm, A.A., Fox, L.K., Leslie, K.E., Hogan, J.S., Andrew, S.M., Moyes, K.M., Oliver, S.P., Schukken, Y.H., Hancock, D.D., Gaskins, C.T., Owens, W.E., Norman, C. J. Dairy Sci. (2006) [Pubmed]
WikiGenes - Universities