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Chemical Compound Review

spiramycin     2-[(4E,6E)-12-[5-(4,5- dihydroxy-4,6...

Synonyms: Foromacidin, Spiramycin I, NSC-55926, NSC55926, AC1NS93C
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Disease relevance of spiramycin


Psychiatry related information on spiramycin

  • Subsequent media and time studies with these strains resulted in a fermentation that produced 1,728 mg of spiramycin per liter [6].

High impact information on spiramycin


Chemical compound and disease context of spiramycin


Biological context of spiramycin


Anatomical context of spiramycin

  • In an attempt to gain information about the peptidyl transferase center at the peptide level we cross-linked the spiramycin derivative dihydrospiramycin to its functional binding site in the 70 S ribosome of Escherichia coli [7].
  • The intracellular penetration of spiramycin is also rapid and extensive, with the concentrations in alveolar macrophages 10 to 20 times greater than simultaneous serum concentrations [10].
  • Of significance to clinicians may be the finding that spiramycin is highly concentrated in the respiratory tract and other tissues and macrophages [10].
  • In three fetuses, concentrations in serum and tissue were measured following intravenous administration of 50 mg of spiramycin twice daily to the mother for at least 7 days [18].
  • The concentration of spiramycin in amniotic fluid was about five times higher than the concentration in fetal serum [18].

Associations of spiramycin with other chemical compounds


Gene context of spiramycin


Analytical, diagnostic and therapeutic context of spiramycin


  1. Failure of spiramycin to prevent neurotoxoplasmosis in immunosuppressed patients. Leport, C., Vilde, J.L., Katlama, C., Regnier, B., Matheron, S., Saimot, A.G. JAMA (1986) [Pubmed]
  2. What is known about the prevention of congenital toxoplasmosis? Jeannel, D., Costagliola, D., Niel, G., Hubert, B., Danis, M. Lancet (1990) [Pubmed]
  3. Acute colitis related to spiramycin. Decaux, G.M., Devroede, C. Lancet (1978) [Pubmed]
  4. Resistance to macrolides, lincosamides and streptogramin type B antibiotics due to a mutation in an rRNA operon of Streptomyces ambofaciens. Pernodet, J.L., Boccard, F., Alegre, M.T., Blondelet-Rouault, M.H., Guérineau, M. EMBO J. (1988) [Pubmed]
  5. Treatment of intestinal cryptosporidiosis with spiramycin. Portnoy, D., Whiteside, M.E., Buckley, E., MacLeod, C.L. Ann. Intern. Med. (1984) [Pubmed]
  6. Selection of Streptomyces ambofaciens mutants that produce large quantities of spiramycin and determination of optimal conditions for spiramycin production. Ford, L.M., Eaton, T.E., Godfrey, O.W. Appl. Environ. Microbiol. (1990) [Pubmed]
  7. Peptide environment of the peptidyl transferase center from Escherichia coli 70 S ribosomes as determined by thermoaffinity labeling with dihydrospiramycin. Bischof, O., Urlaub, H., Kruft, V., Wittmann-Liebold, B. J. Biol. Chem. (1995) [Pubmed]
  8. Erythromycin and spiramycin resistance mutations of yeast mitochondria: nature of the rib2 locus in the large ribosomal RNA gene. Sor, F., Fukuhara, H. Nucleic Acids Res. (1984) [Pubmed]
  9. Separation and determination of the macrolide antibiotics (erythromycin, spiramycin and oleandomycin) by capillary electrophoresis coupled with fast reductive voltammetric detection. Zhou, J., Chen, Y., Cassidy, R. Electrophoresis (2000) [Pubmed]
  10. Pharmacodynamics and pharmacokinetics of spiramycin and their clinical significance. Brook, I. Clinical pharmacokinetics. (1998) [Pubmed]
  11. Comparison of spiramycin and doxycycline for treatment of Chlamydia trachomatis genital infections. Dylewski, J., Clecner, B., Dubois, J., St-Pierre, C., Murray, G., Bouchard, C., Phillips, R. Antimicrob. Agents Chemother. (1993) [Pubmed]
  12. In vitro evaluation of josamycin, spiramycin, and erythromycin against Rickettsia rickettsii and R. conorii. Raoult, D., Roussellier, P., Tamalet, J. Antimicrob. Agents Chemother. (1988) [Pubmed]
  13. Effects of drug therapy on Toxoplasma cysts in an animal model of acute and chronic disease. Gormley, P.D., Pavesio, C.E., Minnasian, D., Lightman, S. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  14. Metronidazole and spiramycin in abscesses caused by Bacteroides spp. and Staphylococcus aureus in mice. Brook, I. J. Antimicrob. Chemother. (1987) [Pubmed]
  15. Molecular analysis of constitutively expressed erm(C) genes selected in vitro in the presence of the non-inducers pirlimycin, spiramycin and tylosin. L??thje, P., Schwarz, S. J. Antimicrob. Chemother. (2007) [Pubmed]
  16. Occupational asthma in workers of a pharmaceutical company processing spiramycin. Malo, J.L., Cartier, A. Thorax (1988) [Pubmed]
  17. Pharmacokinetic interactions of the macrolide antibiotics. Ludden, T.M. Clinical pharmacokinetics. (1985) [Pubmed]
  18. Pharmacokinetics of spiramycin in the rhesus monkey: transplacental passage and distribution in tissue in the fetus. Schoondermark-Van de Ven, E., Galama, J., Camps, W., Vree, T., Russel, F., Meuwissen, J., Melchers, W. Antimicrob. Agents Chemother. (1994) [Pubmed]
  19. Activity of azithromycin against cryptosporidia in immunosuppressed rats. Rehg, J.E. J. Infect. Dis. (1991) [Pubmed]
  20. Erythromycin, carbomycin, and spiramycin inhibit protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes. Menninger, J.R., Otto, D.P. Antimicrob. Agents Chemother. (1982) [Pubmed]
  21. In vitro effects of spiramycin and dirithromycin on IL1 beta production by human LPS-stimulated mononuclear cells. Moutard, I., Gressier, B., Bonte, F., Dine, T., Brunet, C., Luyckx, M., Ballester, L., Cazin, M., Cazin, J.C. Thérapie. (1999) [Pubmed]
  22. Excisable cassettes: new tools for functional analysis of Streptomyces genomes. Raynal, A., Karray, F., Tuphile, K., Darbon-Rongère, E., Pernodet, J.L. Appl. Environ. Microbiol. (2006) [Pubmed]
  23. Macrolide antibacterials. Drug interactions of clinical significance. von Rosensteil, N.A., Adam, D. Drug safety : an international journal of medical toxicology and drug experience. (1995) [Pubmed]
  24. Cloning of spiramycin biosynthetic genes and their use in constructing Streptomyces ambofaciens mutants defective in spiramycin biosynthesis. Richardson, M.A., Kuhstoss, S., Huber, M.L., Ford, L., Godfrey, O., Turner, J.R., Rao, R.N. J. Bacteriol. (1990) [Pubmed]
  25. Macrolide resistance phenotypes and genotypes in French clinical isolates of Streptococcus pneumoniae. Observatoire de Normandie du Pneumocoque. Angot, P., Vergnaud, M., Auzou, M., Leclercq, R. Eur. J. Clin. Microbiol. Infect. Dis. (2000) [Pubmed]
  26. Cryptosporidiosis after marrow transplantation: person-to-person transmission and treatment with spiramycin. Collier, A.C., Miller, R.A., Meyers, J.D. Ann. Intern. Med. (1984) [Pubmed]
  27. Analysis of spiramycin by capillary electrophoresis. González-Hernández, R., Li, Y.M., Van Schepdael, A., Roets, E., Hoogmartens, J. Electrophoresis (1999) [Pubmed]
  28. Spiramycin uptake by alveolar macrophages. Harf, R., Panteix, G., Desnottes, J.F., Diallo, N., Leclercq, M. J. Antimicrob. Chemother. (1988) [Pubmed]
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