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Chemical Compound Review

AC1NUNSZ     (6R,7S)-7-[[(2E)-2-(2-amino- 1,3-thiazol-4...

Synonyms: KB-209051, 80370-57-6, NCGC00167978-01
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Disease relevance of Excenel

  • These findings suggest that CTX-M-2 producers might have originated from cattle through the use of cephalosporins such as ceftiofur and that cattle could be a reservoir of CTX-M-2-producing E. coli [1].
  • Ceftiofur-resistant Salmonella strains isolated from dairy farms represent multiple widely distributed subtypes that evolved by independent horizontal gene transfer [2].
  • Ceftiofur treatment was the only regimen that significantly (P < 0. 05) reduced mortality associated with PRRSV and S. suis coinfection [3].
  • Healthy calves (n = 96, 1 to 9 weeks old) from a dairy herd in central Pennsylvania were examined each month over a five-month period for fecal shedding of ceftiofur-resistant gram-negative bacteria [4].
  • However, for severe clinical mastitis cases caused by coliform organisms, ceftiofur therapy reduced the proportion of cases that resulted in cow death or culling [5].

Psychiatry related information on Excenel


High impact information on Excenel


Chemical compound and disease context of Excenel

  • Treatment with ceftiofur hydrochloride and reduced dose exposure to S. suis were the only treatments which significantly (P<0.05) reduced mortality associated with PRRSV/S. suis coinfection, significantly (P<0.05) reduced recovery of S. suis from tissues at necropsy, and significantly (P<0.05) reduced the severity of gross lung lesions [10].
  • The objective of this study is to determine whether doxycycline, ceftiofur or tetracycline could be effectively used to treat equine Lyme disease [11].
  • OBJECTIVE--To determine the efficacy of intramuscular administration of ceftiofur sodium as treatment for intramammary infections attributable to Streptococcus agalactiae, compared with that for a standard treatment of intramammary infusion of penicillin/novobiocin [12].
  • Efficacy of parenterally or intramammarily administered tilmicosin or ceftiofur against Staphylococcus aureus mastitis during lactation [13].
  • PROCEDURE: Horses received 3 doses of cefepime (11 mg/kg of body weight, PO; 2.2 mg/kg, i.v.; and 2.2 mg/kg, i.m.) and 1 dose of ceftiofur (2.2 mg/kg, i.m.). Two horses also received L-arginine, p.o. and i.v., at doses identical to those contained in the cefepime dihydrochloride-L-arginine preparations previously administered [14].

Biological context of Excenel


Anatomical context of Excenel


Associations of Excenel with other chemical compounds


Gene context of Excenel


Analytical, diagnostic and therapeutic context of Excenel


  1. Escherichia coli producing CTX-M-2 beta-lactamase in cattle, Japan. Shiraki, Y., Shibata, N., Doi, Y., Arakawa, Y. Emerging Infect. Dis. (2004) [Pubmed]
  2. Ceftiofur-resistant Salmonella strains isolated from dairy farms represent multiple widely distributed subtypes that evolved by independent horizontal gene transfer. Alcaine, S.D., Sukhnanand, S.S., Warnick, L.D., Su, W.L., McGann, P., McDonough, P., Wiedmann, M. Antimicrob. Agents Chemother. (2005) [Pubmed]
  3. Efficacy of antimicrobial treatments and vaccination regimens for control of porcine reproductive and respiratory syndrome virus and Streptococcus suis coinfection of nursery pigs. Halbur, P., Thanawongnuwech, R., Brown, G., Kinyon, J., Roth, J., Thacker, E., Thacker, B. J. Clin. Microbiol. (2000) [Pubmed]
  4. Molecular epidemiology of ceftiofur-resistant Escherichia coli isolates from dairy calves. Donaldson, S.C., Straley, B.A., Hegde, N.V., Sawant, A.A., DebRoy, C., Jayarao, B.M. Appl. Environ. Microbiol. (2006) [Pubmed]
  5. Efficacy of systemic ceftiofur as a therapy for severe clinical mastitis in dairy cattle. Erskine, R.J., Bartlett, P.C., VanLente, J.L., Phipps, C.R. J. Dairy Sci. (2002) [Pubmed]
  6. Extended ceftiofur therapy for treatment of experimentally-induced Streptococcus uberis mastitis in lactating dairy cattle. Oliver, S.P., Almeida, R.A., Gillespie, B.E., Headrick, S.J., Dowlen, H.H., Johnson, D.L., Lamar, K.C., Chester, S.T., Moseley, W.M. J. Dairy Sci. (2004) [Pubmed]
  7. Antimicrobial-resistant enteric bacteria from dairy cattle. Sawant, A.A., Hegde, N.V., Straley, B.A., Donaldson, S.C., Love, B.C., Knabel, S.J., Jayarao, B.M. Appl. Environ. Microbiol. (2007) [Pubmed]
  8. Comparison of multilocus sequence typing, pulsed-field gel electrophoresis, and antimicrobial susceptibility typing for characterization of Salmonella enterica serotype Newport isolates. Harbottle, H., White, D.G., McDermott, P.F., Walker, R.D., Zhao, S. J. Clin. Microbiol. (2006) [Pubmed]
  9. Acquisition of resistance to extended-spectrum cephalosporins by Salmonella enterica subsp. enterica serovar Newport and Escherichia coli in the turkey poult intestinal tract. Poppe, C., Martin, L.C., Gyles, C.L., Reid-Smith, R., Boerlin, P., McEwen, S.A., Prescott, J.F., Forward, K.R. Appl. Environ. Microbiol. (2005) [Pubmed]
  10. Influence of ampicillin, ceftiofur, attenuated live PRRSV vaccine, and reduced dose Streptococcus suis exposure on disease associated with PRRSV and S. suis coinfection. Schmitt, C.S., Halbur, P.G., Roth, J.A., Kinyon, J.M., Kasorndorkbua, C., Thacker, B. Vet. Microbiol. (2001) [Pubmed]
  11. Antibiotic treatment of experimentally Borrelia burgdorferi-infected ponies. Chang, Y.F., Ku, Y.W., Chang, C.F., Chang, C.D., McDonough, S.P., Divers, T., Pough, M., Torres, A. Vet. Microbiol. (2005) [Pubmed]
  12. Intramuscular administration of ceftiofur sodium versus intramammary infusion of penicillin/novobiocin for treatment of Streptococcus agalactiae mastitis in dairy cows. Erskine, R.J., Bartlett, P.C., Johnson, G.L., Halbert, L.W. J. Am. Vet. Med. Assoc. (1996) [Pubmed]
  13. Efficacy of parenterally or intramammarily administered tilmicosin or ceftiofur against Staphylococcus aureus mastitis during lactation. Owens, W.E., Nickerson, S.C., Ray, C.H. J. Dairy Sci. (1999) [Pubmed]
  14. Pharmacokinetics of cefepime and comparison with those of ceftiofur in horses. Guglick, M.A., MacAllister, C.G., Clarke, C.R., Pollet, R., Hague, C., Clarke, J.M. Am. J. Vet. Res. (1998) [Pubmed]
  15. Comparative mutagenicity testing of ceftiofur sodium: I. Positive results in in vitro cytogenetics. Aaron, C.S., Yu, R.L., Harbach, P.R., Mazurek, J.M., Swenson, D.H., Kirkland, D., Marshall, R., McEnaney, S. Mutat. Res. (1995) [Pubmed]
  16. Development and in-vitro evaluation of sustained release poloxamer 407 (P407) gel formulations of ceftiofur. Zhang, L., Parsons, D.L., Navarre, C., Kompella, U.B. Journal of controlled release : official journal of the Controlled Release Society. (2002) [Pubmed]
  17. Controlled hydrolysis of ceftiofur sodium, a broad-spectrum cephalosporin; isolation and identification of hydrolysis products. Koshy, K.T., Cazers, A.R. Journal of pharmaceutical sciences. (1997) [Pubmed]
  18. Comparative mutagenicity testing of ceftiofur sodium. II. Cytogenetic damage induced in vitro by ceftiofur is reversible and is due to cell cycle delay. Aaron, C.S., Yu, R.L., Bacon, J.A., Kirkland, D., McEnaney, S., Marshall, R. Mutat. Res. (1995) [Pubmed]
  19. Pharmacokinetics of ceftiofur sodium after intramuscular or subcutaneous administration in green iguanas (Iguana iguana). Benson, K.G., Tell, L.A., Young, L.A., Wetzlich, S., Craigmill, A.L. Am. J. Vet. Res. (2003) [Pubmed]
  20. Pharmacokinetics and concentrations of ceftiofur sodium in body fluids and endometrium after repeated intramuscular injections in mares. Cervantes, C.C., Brown, M.P., Gronwall, R., Merritt, K. Am. J. Vet. Res. (1993) [Pubmed]
  21. Elimination kinetics of ceftiofur hydrochloride after intramammary administration in lactating dairy cows. Smith, G.W., Gehring, R., Riviere, J.E., Yeatts, J.L., Baynes, R.E. J. Am. Vet. Med. Assoc. (2004) [Pubmed]
  22. Effect of intrauterine administration of ceftiofur on fertility and risk of culling in postparturient cows with retained fetal membranes, twins, or both. Scott, H.M., Schouten, M.J., Gaiser, J.C., Belschner, A.P., Jordan, E.R. J. Am. Vet. Med. Assoc. (2005) [Pubmed]
  23. Safety of ceftiofur sodium administered intramuscularly in horses. Mahrt, C.R. Am. J. Vet. Res. (1992) [Pubmed]
  24. Competitive indirect ELISA for ceftiofur sodium and the effect of different immunizing and coating antigen conjugates. Rose, B.G., Kamps-Holtzapple, C., Stanker, L.H. Bioconjug. Chem. (1995) [Pubmed]
  25. Proposed MIC quality control guidelines for National Committee for Clinical Laboratory Standards susceptibility tests using seven veterinary antimicrobial agents: ceftiofur, enrofloxacin, florfenicol, penicillin G-novobiocin, pirlimycin, premafloxacin, and spectinomycin. Marshall, S.A., Jones, R.N., Wanger, A., Washington, J.A., Doern, G.V., Leber, A.L., Haugen, T.H. J. Clin. Microbiol. (1996) [Pubmed]
  26. Treatment of respiratory infections in horses with ceftiofur sodium. Folz, S.D., Hanson, B.J., Griffin, A.K., Dinvald, L.L., Swerczek, T.W., Walker, R.D., Foreman, J.H. Equine Vet. J. (1992) [Pubmed]
  27. Efficacy of ceftiofur hydrochloride sterile suspension administered parenterally for the treatment of acute postpartum metritis in dairy cows. Chenault, J.R., McAllister, J.F., Chester, S.T., Dame, K.J., Kausche, F.M., Robb, E.J. J. Am. Vet. Med. Assoc. (2004) [Pubmed]
  28. Studies on time-kill kinetics of different classes of antibiotics against veterinary pathogenic bacteria including Pasteurella, Actinobacillus and Escherichia coli. Norcia, L.J., Silvia, A.M., Hayashi, S.F. J. Antibiot. (1999) [Pubmed]
  29. Activity of selected antimicrobial agents against strains of Staphylococcus aureus isolated from bovine intramammary infections that produce beta-lactamase. Watts, J.L., Salmon, S.A. J. Dairy Sci. (1997) [Pubmed]
  30. Ceftiofur derivatives in serum, uterine tissues, cotyledons, and lochia after fetal membrane retention. Drillich, M., Arlt, S., Kersting, S., Bergwerff, A.A., Scherpenisse, P., Heuwieser, W. J. Dairy Sci. (2006) [Pubmed]
  31. Investigating the use of an octupole ion guide for ion storage and high-pass mass filtering to improve the quantitative performance of electrospray ion trap mass spectrometry. Voyksner, R.D., Lee, H. Rapid Commun. Mass Spectrom. (1999) [Pubmed]
  32. Determination of ceftiofur in bovine plasma by HPLC-DAD. Jacobson, G.A., Martinod, S., Cunningham, C.P. Journal of pharmaceutical and biomedical analysis. (2006) [Pubmed]
  33. Determination of ceftiofur and its desfuroylceftiofur-related metabolites in swine tissues by high-performance liquid chromatography. Beconi-Barker, M.G., Roof, R.D., Millerioux, L., Kausche, F.M., Vidmar, T.H., Smith, E.B., Callahan, J.K., Hubbard, V.L., Smith, G.A., Gilbertson, T.J. J. Chromatogr. B, Biomed. Appl. (1995) [Pubmed]
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