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Chemical Compound Review

Sodium dichloroacetate     sodium 2,2-dichloroethanoate

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Disease relevance of Dichloroacetate


Psychiatry related information on Dichloroacetate


High impact information on Dichloroacetate


Chemical compound and disease context of Dichloroacetate

  • Previous animal studies have suggested that sodium dichloroacetate (DCA), an agent that decreases lactate production, can improve hemodynamics and survival when administered after severe hemorrhage [12].

Biological context of Dichloroacetate


Anatomical context of Dichloroacetate


Gene context of Dichloroacetate


Analytical, diagnostic and therapeutic context of Dichloroacetate


  1. Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome c oxidase deficiency, oxidative stress and vitamin-responsive lactic acidosis. Grad, L.I., Lemire, B.D. Hum. Mol. Genet. (2004) [Pubmed]
  2. Improved hemodynamic function and mechanical efficiency in congestive heart failure with sodium dichloroacetate. Bersin, R.M., Wolfe, C., Kwasman, M., Lau, D., Klinski, C., Tanaka, K., Khorrami, P., Henderson, G.N., de Marco, T., Chatterjee, K. J. Am. Coll. Cardiol. (1994) [Pubmed]
  3. Short-term dichloroacetate treatment improves indices of cerebral metabolism in patients with mitochondrial disorders. De Stefano, N., Matthews, P.M., Ford, B., Genge, A., Karpati, G., Arnold, D.L. Neurology (1995) [Pubmed]
  4. Metabolic interactions of dichloroacetate and insulin in experimental diabetic ketoacidosis. Backshear, P.J., Holloway, P.A., Alberti, K.G. Biochem. J. (1975) [Pubmed]
  5. Concomitant administration of sodium dichloroacetate and vitamin B1 for lactic acidemia in children with MELAS syndrome. Kuroda, Y., Ito, M., Naito, E., Yokota, I., Matsuda, J., Saijo, T., Kondo, S., Yoneda, Y., Miyazaki, M., Mori, K., Iwamoto, H. J. Pediatr. (1997) [Pubmed]
  6. Therapeutic effect of sodium dichloroacetate on visual and auditory hallucinations in a patient with MELAS. Saijo, T., Naito, E., Ito, M., Takeda, E., Hashimoto, T., Kuroda, Y. Neuropediatrics. (1991) [Pubmed]
  7. Metabolic effects of sodium dichloroacetate in normal and diabetic dogs. Ribes, G., Valette, G., Loubatieres-Mariani, M.M. Diabetes (1979) [Pubmed]
  8. Congestive heart failure and sodium dichloroacetate. Koshkarian, G.M. J. Am. Coll. Cardiol. (1995) [Pubmed]
  9. The metabolic effects of sodium dichloroacetate in the suckling newborn rat. Pegorier, J.P., Ferré, P., Leturque, A., Girard, J. Diabetologia (1978) [Pubmed]
  10. MR spectroscopy study of dichloroacetate treatment after ischemic stroke. Graham, G.D., Barker, P.B., Brooks, W.M., Morris, D.C., Ahmed, W., Bryniarski, E., Hearshen, D.O., Sanders, J.A., Holshouser, B.A., Turkel, C.C. Neurology (2000) [Pubmed]
  11. Magnetic resonance spectroscopy: use in monitoring MELAS treatment. Pavlakis, S.G., Kingsley, P.B., Kaplan, G.P., Stacpoole, P.W., O'Shea, M., Lustbader, D. Arch. Neurol. (1998) [Pubmed]
  12. Effects of dichloroacetate administration during fatal hemorrhagic shock in immature swine. Syverud, S.A., Barsan, W.G., Van Ligten, P.F., Dronen, S.C., Timerding, B., Zink, B.J. Annals of emergency medicine. (1987) [Pubmed]
  13. Nerve conduction changes in patients with mitochondrial diseases treated with dichloroacetate. Spruijt, L., Naviaux, R.K., McGowan, K.A., Nyhan, W.L., Sheean, G., Haas, R.H., Barshop, B.A. Muscle Nerve (2001) [Pubmed]
  14. Dichloroacetate treatment in Leigh syndrome caused by mitochondrial DNA mutation. Takanashi, J., Sugita, K., Tanabe, Y., Maemoto, T., Niimi, H. J. Neurol. Sci. (1997) [Pubmed]
  15. Activation of pyruvate dehydrogenase improves heart function and metabolism after hemorrhagic shock. Kline, J.A., Maiorano, P.C., Schroeder, J.D., Grattan, R.M., Vary, T.C., Watts, J.A. J. Mol. Cell. Cardiol. (1997) [Pubmed]
  16. Proton magnetic resonance spectroscopy to study the metabolic changes in the brain of a patient with Leigh syndrome. Takahashi, S., Oki, J., Miyamoto, A., Okuno, A. Brain Dev. (1999) [Pubmed]
  17. Novel mutations in a boy with dihydrolipoamide dehydrogenase deficiency. Cerna, L., Wenchich, L., Hansiková, H., Kmoch, S., Peskova, K., Chrastina, P., Brynda, J., Zeman, J. Med. Sci. Monit. (2001) [Pubmed]
  18. Effects of sodium dichloroacetate dose. Brain metabolites associated with cerebral ischemia. Dimlich, R.V., Timerding, B.L., Kaplan, J., Cammenga, R., Van Ligten, P.F. Annals of emergency medicine. (1989) [Pubmed]
  19. Beneficial effect of sodium dichloroacetate in muscle cytochrome C oxidase deficiency. Burlina, A.B., Milanesi, O., Biban, P., Bordugo, A., Garavaglia, B., Zacchello, F., DiMauro, S. Eur. J. Pediatr. (1993) [Pubmed]
  20. Concomitant administration of sodium dichloroacetate and thiamine in west syndrome caused by thiamine-responsive pyruvate dehydrogenase complex deficiency. Naito, E., Ito, M., Yokota, I., Saijo, T., Chen, S., Maehara, M., Kuroda, Y. J. Neurol. Sci. (1999) [Pubmed]
  21. Therapeutic effect and [123I]IMP SPECT findings of sodium dichloroacetate in a patient with MELAS. Sudo, A., Sasaki, M., Sugai, K., Matsuda, H. Neurology (2004) [Pubmed]
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