Disease relevance of Dichloroacetate

• The lactic acidosis induced by the NDUFV1 mutations could be partially corrected with the vitamins riboflavin and thiamine or with sodium dichloroacetate, an activator of the pyruvate dehydrogenase complex, resulting in significant increases in animal fitness [1].
• Improved hemodynamic function and mechanical efficiency in congestive heart failure with sodium dichloroacetate [2].
• We performed a short-term, double-blind, placebo-controlled, crossover trial of sodium dichloroacetate (DCA) therapy in 11 patients affected by various primary mitochondrial disorders [3].
• 1. The infusion of sodium dichloroacetate into rats with severe diabetic ketoacidosis over 4h caused a 2mM decrease in blood glucose, and small falls in blood lactate and pyruvate concentrations [4].
• Concomitant administration of sodium dichloroacetate and vitamin B1 for lactic acidemia in children with MELAS syndrome [5].

Psychiatry related information on Dichloroacetate

• Therapeutic effect of sodium dichloroacetate on visual and auditory hallucinations in a patient with MELAS [6].

High impact information on Dichloroacetate

• Metabolic effects of sodium dichloroacetate in normal and diabetic dogs [7].
• Congestive heart failure and sodium dichloroacetate [8].
• Subcutaneous injection of sodium dichloroacetate (1 microgram/ g body wt every 3 h) in suckling newborn rats caused in 6 h a fall of 2.5 mmol/l in blood glucose concentrations, and a rise of 2.4 mmol/l in total blood ketone body levels, but no change in the high levels of plasma non esterified fatty acids [9].
• In a double-blind, placebo-controlled study, we used 1H MR spectroscopy to assess the effect of a single infusion of sodium dichloroacetate on lesion lactate 1 to 5 days after ischemic stroke [10].
• PATIENT: A patient with MELAS and a strokelike episode clinically improved after treatment with sodium dichloroacetate [11].

Chemical compound and disease context of Dichloroacetate

• Previous animal studies have suggested that sodium dichloroacetate (DCA), an agent that decreases lactate production, can improve hemodynamics and survival when administered after severe hemorrhage [12].

Biological context of Dichloroacetate

• Serial measurements of nerve conduction velocities and amplitudes were performed in 27 patients with congenital lactic acidemia over 1 year of sodium dichloroacetate (DCA) administration [13].
• Sodium dichloroacetate (DCA) was administered to a 1-year-old female case of Leigh syndrome, who had a T > G point mutation at nt 8993 of mitochondrial DNA [14].

Anatomical context of Dichloroacetate

• Rats were hemorrhaged via femoral artery to 25-30 mmHg mean arterial pressure (MAP) for 60 min, followed by retransfusion of shed blood with either 1.0 cc saline with no dichloroacetate (-DCA) or 1.0 cc saline containing 150 mg/kg sodium dichloroacetate (+DCA) [15].
• In this patient, sodium dichloroacetate therapy normalized the lactate and pyruvate levels in both blood and cerebrospinal fluid (CSF) [16].
• CONCLUSIONS: The prognosis for children with DLD deficiency is unfavorable, although long-term normalization of most metabolites in body fluids may be achieved with the proper diet and the administration of sodium dichloroacetate [17].

Gene context of Dichloroacetate

• Effects of sodium dichloroacetate dose. Brain metabolites associated with cerebral ischemia [18].
• Beneficial effect of sodium dichloroacetate in muscle cytochrome C oxidase deficiency [19].
• Infantile spasms occurred in association with elevated blood and CSF lactate concentrations; these symptoms disappeared when lactate concentrations had been lowered by treatment with concomitant sodium dichloroacetate (DCA) and high dose thiamine [20].
• A high-fat, low-protein diet supplemented with MCT oils and sodium dichloroacetate resulted in normalization of lactate, amino acids and organic acids in body fluids, but there was no improvement in psychomotor development [17].

Analytical, diagnostic and therapeutic context of Dichloroacetate

• Therapeutic effect and [123I]IMP SPECT findings of sodium dichloroacetate in a patient with MELAS [21].

References