Disease relevance of nitro ethaneperoxoate

• Peroxyacetyl nitrate (PAN), an ubiquitous air pollutant, induced apoptosis in human leukemia HL-60, human chronic myelogenous leukemia K-562, and mouse monocyte-macrophage RAW 264.7 cell lines [1].
• Mutagenicity in lung of big Blue((R)) mice and induction of tandem-base substitutions in Salmonella by the air pollutant peroxyacetyl nitrate (PAN): predicted formation of intrastrand cross-links [2].
• Mutagenicity of peroxyacetyl nitrate (PAN) in vivo: tests for somatic mutations and chromosomal aberrations [3].
• Peroxyacetyl nitrate: review of toxicity [4].
• Effects of exposure to peroxyacetyl nitrate on susceptibility to acute and chronic bacterial infection [5].

High impact information on nitro ethaneperoxoate

• There is uncertainty in the mechanism for the hydrolysis of peroxyacetyl nitrate (PAN), and experimental attempts to detect products of the direct reaction have been unsuccessful [6].
• Peroxyacetyl nitrate-induced apoptosis through generation of reactive oxygen species in HL-60 cells [1].
• Nitrate radical quantum yield from peroxyacetyl nitrate photolysis [7].
• Cytogenetic analyses of the in vitro and in vivo responses of murine cells to peroxyacetyl nitrate (PAN) [8].
• Exposures of Salmonella typhimurium strain TA100 with and without S9 metabolic activation to low ppm levels of pure peroxyacetyl nitrate (PAN) in the gas phase were conducted [9].

Biological context of nitro ethaneperoxoate

• Short-term inhalation toxicity studies with peroxyacetyl nitrate in rats [10].
• Regional air pollution issues such as acid rain, long-range transport of aerosols and visibility loss, and the connections of aerosols to ozone and peroxyacetyl nitrate chemistry are examined [11].

Anatomical context of nitro ethaneperoxoate

• Peroxyacetyl nitrate: measurement of its mutagenic activity using the Salmonella/mammalian microsome reversion assay [9].

Associations of nitro ethaneperoxoate with other chemical compounds

• In Los Angeles, contaminants include carbon monoxide, ozone, peroxyacetylnitrate (PAN) and nitrogen oxides, whereas in older European cities, such as Sarajevo, "reducing smog" of sulfur dioxide is the main hazard [12].
• Measurements of peroxyacetyl nitrate (PAN), NO, NO2, HNO3, NOy (total odd nitrogen), and O3 were made in the high-latitude troposphere over North America and Greenland (35 degrees to 82 degrees N) during the Arctic Boundary Layer Expedition (ABLE 3A) (July-August 1988) throughout 0-to 6-km altitudes [13].

Gene context of nitro ethaneperoxoate

• Pulmonary function desensitization on repeated exposures to the combination of peroxyacetyl nitrate and ozone [14].

Analytical, diagnostic and therapeutic context of nitro ethaneperoxoate

• Near real-time measurements of light non-methane hydrocarbons (NMHCs) and peroxyacetyl nitrate (PAN) have been performed in the free troposphere using two fast gas chromatography (GC) instruments designed for use on aircraft [15].

References