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MeSH Review

Los Angeles

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Disease relevance of Los Angeles

  • HIV incidence among injection drug users enrolled in a Los Angeles methadone program [1].
  • SETTING--On February 14, 1992, more than 100 passengers on a flight from South America to Los Angeles, Calif, were infected with toxigenic Vibrio cholerae O1 [2].
  • Among patients with the acquired immunodeficiency syndrome (AIDS) who were hospitalized in New York City, San Francisco, Calif, and Los Angeles, Calif, from 1983 through 1988, we observed a marked shift in the payer distribution toward Medicaid and away from private insurance [3].
  • Characteristics of Los Angeles, Calif., residents in whom carcinomas of the cervix, vulva, vagina, anus, and penis were diagnosed during the period 1972-81 were compared with those of all residents and with those in whom any cancer was diagnosed during the same period [4].
  • INTERPRETATION: The A49T variant of the SRD5A2 gene may be a significant contributor to the incidence of prostate cancer in African-American and Hispanic men in Los Angeles. We estimate that the population attributable risk due to this aminoacid substitution for clinically significant disease is about 8% in both populations [5].

Psychiatry related information on Los Angeles


High impact information on Los Angeles

  • An HLA-matching method based on compatibility at 10 key amino acid residues of HLA-A and B molecules and a limited number of HLA-DR types was evaluated with use of the HLA types of the patients currently on the national waiting list and waiting lists in Los Angeles and Birmingham, Alabama. RESULTS [11].
  • Interviews of 45 patients and 89 matched controls in Los Angeles County showed that illness was associated with penicillin or tetracycline use during the month before onset (P less than 0.001) and with eating ground beef during the week before onset (P = 0.052) [12].
  • Tectonic contraction across Los Angeles after removal of groundwater pumping effects [13].
  • SETTING: Three states (California, Utah, and Vermont) and 6 cities (Boulder, Colo; Flagstaff, Ariz; Los Angeles, Calif; Mesa, Ariz; New York, NY; and San Francisco, Calif) in which the effect on tourism of smoke-free restaurant ordinances had been debated [14].
  • Five counties in Southern California including Los Angeles, Orange, San Bernardino, Riverside, and San Diego. PARTICIPANTS [15].

Chemical compound and disease context of Los Angeles


Biological context of Los Angeles


Anatomical context of Los Angeles


Associations of Los Angeles with chemical compounds

  • This report gives the results of assays of circulating steroid hormone levels in white and black college students in Los Angeles, CA [30].
  • Sixty-five surgically excised, formalin-fixed endometrial tissue specimens were accessioned through the Department of Pathology Registry at the University of California, Los Angeles, and analyzed for UPAR expression by using immunohistochemical techniques [31].
  • Patients received alternate 90-second balloon inflations with and without distal perfusion of oxygenated perfluorochemical (Fluosol, Alpha Therapeutic Corp., Los Angeles, California) at 60 ml/min [32].
  • The experiments were performed in Bochum, and the calculations were carried out in Osaka and Los Angeles. As the cyclobutene ring-opening transition structure approaches planarity, the energy gap between allowed conrotatory and the forbidden disrotatory pathways decreases [33].
  • Studies at the University of California, Los Angeles, Medical Center suggest that amikacin interacts more frequently in a synergistic manner with beta-lactams than do alternative aminoglycosides [34].

Gene context of Los Angeles

  • Three hundred twenty-eight non-Hispanic white residents of Los Angeles County (265 males and 63 females) were genotyped for the presence or absence of GSTM1 alleles and phenotyped for CYP1A2 activity [35].
  • On the other hand, comparison of either series from Mexico-city with the Los Angeles or the San Antonio studies yielded discrepancies in several specificities of both HLA-A and B loci, most notably the consistent absence of A25 in Mexican Mestizos living in Mexico-City [36].
  • There were no significant difference in the relative mRNA expression levels of CXCR-1 and -2 among endoscopic grades of RE based on the Los Angeles classification [37].
  • The study was performed at the Clinical Research Center of the Childrens Hospital, Los Angeles. The effects of alpha-helical CRH on autonomic parameters (blood pressure, pulse, temperature, respiration) were determined [38].
  • Approximately 12% of the U.S. population is Hispanic, with the majority residing in urban centers such as Los Angeles. The prevalence of BRCA mutations among high-risk Hispanic families is unknown [39].

Analytical, diagnostic and therapeutic context of Los Angeles

  • To evaluate the protective efficacy of polyribosylribitol phosphate (PRP) and polyribosylribitol phosphate-diphtheria toxoid (PRP-D) vaccines in children 18 to 59 months of age, we conducted a case-control study in Los Angeles (Calif) County between July 1, 1988, and July 31, 1989 [40].
  • We studied 41 cases of HCC from the Los Angeles area for evidence of EBV infection by in situ hybridization, immunohistochemistry, and polymerase chain reaction methods [41].
  • The RAND 36-item general health survey, University of California Los Angeles Prostate Cancer Index, American Urological Association symptom index, validated Cancer Interference with Life and Family Scales, and sociodemographic and co-morbidity questionnaires were completed 3 to 17 months after treatment [42].
  • MATERIALS AND METHODS: We tested the characteristics of the percent free PSA monoclonal Immulite DPC Immunoassay (Diagnostic Products Corp., Los Angeles, California) for predicting organ confinement in 698 consecutive unscreened men treated only with radical prostatectomy between 1995 and 2000 [43].
  • Amplification of the beta-globin gene by the polymerase chain reaction (PCR) and direct sequencing were used for a fast and reliable identification of the beta-globin variant Hb D Los Angeles and revealed the predicted G----C substitution in codon 121 [44].


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  2. Diagnosis and treatment of cholera in the United States. Are we prepared? Besser, R.E., Feikin, D.R., Eberhart-Phillips, J.E., Mascola, L., Griffin, P.M. JAMA (1994) [Pubmed]
  3. The 'Medicaidization' of AIDS. Trends in the financing of HIV-related medical care. Green, J., Arno, P.S. JAMA (1990) [Pubmed]
  4. Parallels in the epidemiology of selected anogenital carcinomas. Peters, R.K., Mack, T.M., Bernstein, L. J. Natl. Cancer Inst. (1984) [Pubmed]
  5. Association of mis-sense substitution in SRD5A2 gene with prostate cancer in African-American and Hispanic men in Los Angeles, USA. Makridakis, N.M., Ross, R.K., Pike, M.C., Crocitto, L.E., Kolonel, L.N., Pearce, C.L., Henderson, B.E., Reichardt, J.K. Lancet (1999) [Pubmed]
  6. Hepatitis, alcohol consumption, cigarette smoking, and hepatocellular carcinoma in Los Angeles. Yu, M.C., Mack, T., Hanisch, R., Peters, R.L., Henderson, B.E., Pike, M.C. Cancer Res. (1983) [Pubmed]
  7. Epidemiologic evidence on cocaine use and panic attacks. Anthony, J.C., Tien, A.Y., Petronis, K.R. Am. J. Epidemiol. (1989) [Pubmed]
  8. Preventing alcohol, marijuana, and cigarette use among adolescents: peer pressure resistance training versus establishing conservative norms. Hansen, W.B., Graham, J.W. Preventive medicine. (1991) [Pubmed]
  9. Use ecology and drug use motivations of methamphetamine users admitted to substance abuse treatment facilities in Los Angeles: an emerging profile. von, M.C., Brecht, M.L., Anglin, M.D. Journal of addictive diseases : the official journal of the ASAM, American Society of Addiction Medicine. (2002) [Pubmed]
  10. Drug-related HIV risk behaviors and cocaine preference among injection drug users in Los Angeles. Longshore, D., Anglin, M.D., Hsieh, S.C., Annon, K. Journal of drug education. (1993) [Pubmed]
  11. Equitable allocation of HLA-compatible kidneys for local pools and minorities. Takemoto, S., Terasaki, P.I., Gjertson, D.W., Cecka, J.M. N. Engl. J. Med. (1994) [Pubmed]
  12. Chloramphenicol-resistant Salmonella newport traced through hamburger to dairy farms. A major persisting source of human salmonellosis in California. Spika, J.S., Waterman, S.H., Hoo, G.W., St Louis, M.E., Pacer, R.E., James, S.M., Bissett, M.L., Mayer, L.W., Chiu, J.Y., Hall, B. N. Engl. J. Med. (1987) [Pubmed]
  13. Tectonic contraction across Los Angeles after removal of groundwater pumping effects. Bawden, G.W., Thatcher, W., Stein, R.S., Hudnut, K.W., Peltzer, G. Nature (2001) [Pubmed]
  14. Tourism and hotel revenues before and after passage of smoke-free restaurant ordinances. Glantz, S.A., Charlesworth, A. JAMA (1999) [Pubmed]
  15. A case-control study of routine and death scene sleep position and sudden infant death syndrome in Southern California. Klonoff-Cohen, H.S., Edelstein, S.L. JAMA (1995) [Pubmed]
  16. Vitamin D metabolite-mediated hypercalcemia and hypercalciuria patients with AIDS- and non-AIDS-associated lymphoma. Adams, J.S., Fernandez, M., Gacad, M.A., Gill, P.S., Endres, D.B., Rasheed, S., Singer, F.R. Blood (1989) [Pubmed]
  17. Phagocytic activation of human neutrophils by the detergent component of fluosol. Ingram, D.A., Forman, M.B., Murray, J.J. Am. J. Pathol. (1992) [Pubmed]
  18. The efficacy of lovastatin in lowering cholesterol in African Americans with primary hypercholesterolemia. Fong, R.L., Ward, H.J. Am. J. Med. (1997) [Pubmed]
  19. Identifying stroke in the field. Prospective validation of the Los Angeles prehospital stroke screen (LAPSS). Kidwell, C.S., Starkman, S., Eckstein, M., Weems, K., Saver, J.L. Stroke (2000) [Pubmed]
  20. Relationship of isoniazid resistance to human immunodeficiency virus infection in patients with tuberculosis. Asch, S., Knowles, L., Rai, A., Jones, B.E., Pogoda, J., Barnes, P.F. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  21. Classical galactosemia and mutations at the galactose-1-phosphate uridyl transferase (GALT) gene. Tyfield, L., Reichardt, J., Fridovich-Keil, J., Croke, D.T., Elsas, L.J., Strobl, W., Kozak, L., Coskun, T., Novelli, G., Okano, Y., Zekanowski, C., Shin, Y., Boleda, M.D. Hum. Mutat. (1999) [Pubmed]
  22. Estimated fluoride intake of 6-month-old infants in four dietary regions of the United States. Ophaug, R.H., Singer, L., Harland, B.F. Am. J. Clin. Nutr. (1980) [Pubmed]
  23. Lung cancer risk in relation to the CYP2C9*1/CYP2C9*2 genetic polymorphism among African-Americans and Caucasians in Los Angeles County, California. London, S.J., Daly, A.K., Leathart, J.B., Navidi, W.C., Idle, J.R. Pharmacogenetics (1996) [Pubmed]
  24. Replacement of isoleucine-397 by threonine in the clotting proteinase factor IXa (Los Angeles and Long Beach variants) affects macromolecular catalysis but not L-tosylarginine methyl ester hydrolysis. Lack of correlation between the ox brain prothrombin time and the mutation site in the variant proteins. Spitzer, S.G., Warn-Cramer, B.J., Kasper, C.K., Bajaj, S.P. Biochem. J. (1990) [Pubmed]
  25. IGF1 genotype, mean plasma level and breast cancer risk in the Hawaii/Los Angeles multiethnic cohort. DeLellis, K., Ingles, S., Kolonel, L., McKean-Cowdin, R., Henderson, B., Stanczyk, F., Probst-Hensch, N.M. Br. J. Cancer (2003) [Pubmed]
  26. Peripheral hepatic arterial embolization with crosslinked collagen fibers. Daniels, J.R., Kerlan, R.K., Dodds, L., McLaughlin, P., LaBerge, J.M., Harrington, D., Daniels, A.M., Ring, E.J. Investigative radiology. (1987) [Pubmed]
  27. Pancreatic sarcoidosis. Garcia, C., Kumar, V., Sharma, O.P. Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders. (1996) [Pubmed]
  28. Descriptive epidemiology of thyroid cancer in Los Angeles County, 1972-1995. Haselkorn, T., Bernstein, L., Preston-Martin, S., Cozen, W., Mack, W.J. Cancer Causes Control (2000) [Pubmed]
  29. Surgical treatment of hyperthyroidism in children. Wesley, J.R., Buckingham, B.A., Gahr, J.A., Isaacs, H., Kogut, M.D., Weitzman, J.J. Surgery, gynecology & obstetrics. (1977) [Pubmed]
  30. Serum testosterone levels in healthy young black and white men. Ross, R., Bernstein, L., Judd, H., Hanisch, R., Pike, M., Henderson, B. J. Natl. Cancer Inst. (1986) [Pubmed]
  31. Urokinase plasminogen activator receptor: Prognostic biomarker for endometrial cancer. Memarzadeh, S., Kozak, K.R., Chang, L., Natarajan, S., Shintaku, P., Reddy, S.T., Farias-Eisner, R., Memarzedeh, S. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  32. Perfluorochemical perfusion during coronary angioplasty in unstable and high-risk patients. Cowley, M.J., Snow, F.R., DiSciascio, G., Kelly, K., Guard, C., Nixon, J.V. Circulation (1990) [Pubmed]
  33. Altering the allowed/forbidden gap in cyclobutene electrocyclic reactions: experimental and theoretical evaluations of the effect of planarity constraints. Lee, P.S., Sakai, S., Hörstermann, P., Roth, W.R., Kallel, E.A., Houk, K.N. J. Am. Chem. Soc. (2003) [Pubmed]
  34. Use of aminoglycosides in immunocompromised patients. Young, L.S. Am. J. Med. (1985) [Pubmed]
  35. Absence of the glutathione S-transferase M1 gene increases cytochrome P4501A2 activity among frequent consumers of cruciferous vegetables in a Caucasian population. Probst-Hensch, N.M., Tannenbaum, S.R., Chan, K.K., Coetzee, G.A., Ross, R.K., Yu, M.C. Cancer Epidemiol. Biomarkers Prev. (1998) [Pubmed]
  36. HLA profile of the Mexican Mestizo population. Arellano, J., Vallejo, M., Estrada, H.G., Kretschmer, R.R. Tissue Antigens (1981) [Pubmed]
  37. Expression of CXC receptor 1 and 2 in esophageal mucosa of patients with reflux esophagitis. Isomoto, H., Kanazawa, Y., Nishi, Y., Wen, C.Y., Inoue, K., Kohno, S. World J. Gastroenterol. (2005) [Pubmed]
  38. Infantile spasms: hypothesis-driven therapy and pilot human infant experiments using corticotropin-releasing hormone receptor antagonists. Baram, T.Z., Mitchell, W.G., Brunson, K., Haden, E. Dev. Neurosci. (1999) [Pubmed]
  39. Prevalence of BRCA mutations and founder effect in high-risk Hispanic families. Weitzel, J.N., Lagos, V., Blazer, K.R., Nelson, R., Ricker, C., Herzog, J., McGuire, C., Neuhausen, S. Cancer Epidemiol. Biomarkers Prev. (2005) [Pubmed]
  40. Protective efficacy of Haemophilus influenzae type b polysaccharide and conjugate vaccines in children 18 months of age and older. Greenberg, D.P., Vadheim, C.M., Bordenave, N., Ziontz, L., Christenson, P., Waterman, S.H., Ward, J.I. JAMA (1991) [Pubmed]
  41. No direct role for Epstein-Barr virus in American hepatocellular carcinoma. Chu, P.G., Chen, Y.Y., Chen, W., Weiss, L.M. Am. J. Pathol. (2001) [Pubmed]
  42. Quality of life outcomes after brachytherapy for early stage prostate cancer. Brandeis, J.M., Litwin, M.S., Burnison, C.M., Reiter, R.E. J. Urol. (2000) [Pubmed]
  43. Percent free prostate specific antigen is not an independent predictor of organ confinement or prostate specific antigen recurrence in unscreened patients with localized prostate cancer treated with radical prostatectomy. Graefen, M., Karakiewicz, P.I., Cagiannos, I., Hammerer, P.G., Haese, A., Palisaar, J., Huland, E., Scardino, P.T., Kattan, M.W., Huland, H. J. Urol. (2002) [Pubmed]
  44. Hb D Los Angeles (D-Punjab) and Hb Presbyterian: analysis of the defect at the DNA level. Schnee, J., Aulehla-Scholz, C., Eigel, A., Horst, J. Hum. Genet. (1990) [Pubmed]
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