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Chemical Compound Review

HMDB02098     (2R,3R,4R,5R)-4- [(2S,3R,4S,5R,6R)-4,5...

Synonyms: AC1L55O8, 2'FL, 41263-94-9, 2-Fucosyllactose, 2'-Fucosyllactose
 
 
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Disease relevance of 2'-Fucosyllactose

 

High impact information on 2'-Fucosyllactose

 

Biological context of 2'-Fucosyllactose

  • In colostrum and mature milk (30 d lactation), lacto-N-fucopentaose (LNFP) I was the most abundant oligosaccharide, followed by 2'-fucosyllactose (2'-FL) + lacto-N-difucotetraose (LNDFT), LNFP II + lacto-N-difucohexaose II (LNDFH II), and 3-fucosyllactose (3-FL) [6].
  • Hemagglutination inhibition was observed with 2'-fucosyllactose (Type 2 H) and lacto-N-fucopentose-I (Type 1 H), suggesting that the binding of the lectin had preference for H structures [7].
 

Anatomical context of 2'-Fucosyllactose

 

Associations of 2'-Fucosyllactose with other chemical compounds

 

Gene context of 2'-Fucosyllactose

  • The alpha 1,3-FT activity towards 2'-fucosyllactose was found to be associated with alpha 1,4-FT activity [10].
 

Analytical, diagnostic and therapeutic context of 2'-Fucosyllactose

References

  1. Molecular cloning and characterization of Bifidobacterium bifidum 1,2-alpha-L-fucosidase (AfcA), a novel inverting glycosidase (glycoside hydrolase family 95). Katayama, T., Sakuma, A., Kimura, T., Makimura, Y., Hiratake, J., Sakata, K., Yamanoi, T., Kumagai, H., Yamamoto, K. J. Bacteriol. (2004) [Pubmed]
  2. Multiple fucosyltransferases and their carbohydrate ligands are involved in spermatogenic cell-Sertoli cell adhesion in vitro in rats. Raychoudhury, S.S., Millette, C.F. Biol. Reprod. (1997) [Pubmed]
  3. Purification and characterization of alpha-L-fucosidase from Chinese hamster ovary cell culture supernatant. Gramer, M.J., Schaffer, D.V., Sliwkowski, M.B., Goochee, C.F. Glycobiology (1994) [Pubmed]
  4. Substrate specificity of fucosyltransferase purified from human parotid saliva. Tamagawa, H., Iwakura, K., Amano, A., Shizukuishi, S., Tsunemitsu, A. J. Dent. Res. (1987) [Pubmed]
  5. Purification and characterization of a lymph node sulfotransferase responsible for 6-O-sulfation of the galactose residues in 2'-fucosyllactose and other sialyl LewisX-related sugars. Shailubhai, K., Khai Huynh, Q., Boddupalli, H., Yu, H.H., Jacob, G.S. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  6. Determination of each neutral oligosaccharide in the milk of Japanese women during the course of lactation. Sumiyoshi, W., Urashima, T., Nakamura, T., Arai, I., Saito, T., Tsumura, N., Wang, B., Brand-Miller, J., Watanabe, Y., Kimura, K. Br. J. Nutr. (2003) [Pubmed]
  7. An unusual anti-H lectin inhibited by milk from individuals with the Bombay phenotype. Joshi, S.R., Vasantha, K., Robb, J.S. Immunohematology / American Red Cross. (2005) [Pubmed]
  8. Occurrence of an unusual lactose sulfate in dog milk. Bubb, W.A., Urashima, T., Kohso, K., Nakamura, T., Arai, I., Saito, T. Carbohydr. Res. (1999) [Pubmed]
  9. Isolation and characterization from porcine serum of a soluble sulfotransferase responsible for 6-O-sulfation of the galactose residue in 2'-fucosyllactose: implications in the synthesis of the ligand for L-selectin. Huynh, Q.K., Shailubhai, K., Boddupalli, H., Yu, H.H., Broschat, K.O., Jacob, G.S. Glycoconj. J. (1999) [Pubmed]
  10. Lactose as affinity eluent and a synthetic sulfated copolymer as inhibitor, in conjunction with synthetic and natural acceptors, differentiate human milk Lewis-type and plasma-type alpha-L-fucosyltransferases. Chandrasekaran, E.V., Rhodes, J.M., Jain, R.K., Matta, K.L. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  11. Synthesis of the milk oligosaccharide 2'-fucosyllactose using recombinant bacterial enzymes. Albermann, C., Piepersberg, W., Wehmeier, U.F. Carbohydr. Res. (2001) [Pubmed]
 
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