Disease relevance of l-Papthion

• Cidial was found to increase the percentage of cells with chromosomal aberrations in both mothers and fetuses [1].
• Furthermore, the activities of malathion and phenthoate carboxylesterases may be useful for detecting lung injury produced by pneumotoxic chemicals as well as bacterial infection [2].
• Furthermore, infection of rats with Pseudomonas aeruginosa by intratracheal inoculation increased malathion and phenthoate carboxylesterase activities in PAM by two- to threefold without increasing these activities in lung microsomes [2].
• The toxicities of carbaryl and phenthoate have been discussed in relation to sensitivity of the species and their interaction with the target enzyme [3].
• The resistant strain did not show cross-resistance to chlorfluazuron or Bacillus thuringiensis subsp kurstaki Berliner, but displayed low resistance to cartap and phenthoate [4].

High impact information on l-Papthion

• Cidial was administered at three different dose levels (53.5, 106.9, and 171 mg/kg) to pregnant mice on day 16 of gestation [1].
• Malathion and phenthoate carboxylesterase activities were investigated in pulmonary alveolar macrophages (PAM) in Sprague-Dawley rats [2].
• Malathion and phenthoate carboxylesterase activities in pulmonary alveolar macrophages as indicators of lung injury [2].
• Exposure to these OPs caused a dose-dependent effect on cell viability, and significantly reduced the mean fission rate at a concentration of 1/10(5) v/v. After exposure of resting cysts to 1/10(5) v/v or 1/10(6) v/v concentrations of basudin or cidial, the number of excysted cells was significantly lower than that of the controls [5].
• It is likely that GR acted on the specific structure of malathion and phenthoate, the S=P-S bond, and the blanch structure bonding with the sulfur atom [6].

Biological context of l-Papthion

• On return to phenthoate-free fresh water, the decline in enzyme activity and rise in ACh concentration was found to persist for up to 20 days following exposure [7].
• Phenthoate degradation was attributed to the action of extracellular heat-labile soil enzymes which converted to its carbon ester hydrolysis product, phenthoate acid [8].
• Phenthoate acid was extensively degraded to 14CO2 by soil organisms under aerobic conditions, but due to unfavorable factors, degraded only by slow first-order kinetics under anaerobic conditions and at the 100 ppm fortification level under aerobic conditions [8].

Associations of l-Papthion with other chemical compounds

• 0. The major hydrolysis products were phenthoate acid, demethyl phenthoate and demethyl phenthoate oxon [9].

Gene context of l-Papthion

• Carbaryl in combination with phenthoate exerted synergism on the AChE system during their interaction [10].
• Among 1233A and its synthetic analogs, trans-3-hydroxymethyl-4-[2-(7-methoxycarbonyl-1-naphthyl)ethyl]-2-oxe tanone (23) showed the highest HMG-CoA synthase inhibitory activity in vitro [11].
• Rats receiving 2.5 to 10 mg/kg phenthoate for 13 weeks showed varying decreases in weights of liver, heart, spleen, brain, testes and adrenals [12].

Analytical, diagnostic and therapeutic context of l-Papthion

• Fast and precise determination of phenthoate and its enantiomeric ratio in soil by the matrix solid-phase dispersion method and liquid chromatography [13].
• The MSPD extract was directly used for quantitative determination of phenthoate by silica-based high-performance liquid chromatography (HPLC) with UV detection [13].
• Intact phenthoate was detected only in gastric lavage fluid [14].

References