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Chemical Compound Review

Demethyl     [2-[ (6S,8R,9R,10S,11S,13S,14S,17R) -11,17...

Synonyms: Solsolona, Ubrason, Unidrol, Mepred, Vetacortyl, ...
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Disease relevance of Depo-Methylprednisolone acetate


High impact information on Depo-Methylprednisolone acetate


Chemical compound and disease context of Depo-Methylprednisolone acetate


Biological context of Depo-Methylprednisolone acetate


Anatomical context of Depo-Methylprednisolone acetate


Associations of Depo-Methylprednisolone acetate with other chemical compounds


Gene context of Depo-Methylprednisolone acetate

  • Stepwise regression analysis including tacrolimus, its metabolites, and liver function parameters suggested a model including serum activities of gamma-glutamyltransferase, alkaline phosphatase, and alanine aminotransferase as predictors for increased concentrations of demethyl tacrolimus, didemethyl tacrolimus, and the parent drug [28].
  • Serial measurements of sIL-2R levels were made over 24 weeks in 40 patients with RA, treated with intramuscular (im) gold plus 3 im injections of either 120 mg methylprednisolone acetate or placebo [29].
  • Methylprednisolone acetate (4.2 mg/kg/week) reduced clinical signs of inflammation in a manner comparable to TNF blockade but had little effect on the incidence of erosions [30].
  • Cu(II).BLM demethyl A2 was found to be much less effective than Cu(II).BLM A2 as a DNA unwinding agent, emphasizing the strong dependence of this process on the presence of positively charged groups within the BLM molecule [31].
  • With the aim of exploring putative correlations between serum and CSF levels of clozapine and its demethyl metabolite, lumbar puncture was performed on four male and five female schizophrenic patients during long-term treatment with clozapine [32].

Analytical, diagnostic and therapeutic context of Depo-Methylprednisolone acetate


  1. A controlled trial of corticosteroid injections into facet joints for chronic low back pain. Carette, S., Marcoux, S., Truchon, R., Grondin, C., Gagnon, J., Allard, Y., Latulippe, M. N. Engl. J. Med. (1991) [Pubmed]
  2. Epidural corticosteroid injections for sciatica due to herniated nucleus pulposus. Carette, S., Leclaire, R., Marcoux, S., Morin, F., Blaise, G.A., St-Pierre, A., Truchon, R., Parent, F., Levésque, J., Bergeron, V., Montminy, P., Blanchette, C. N. Engl. J. Med. (1997) [Pubmed]
  3. Depletion of mucosal mast cell protease by corticosteroids: effect on intestinal anaphylaxis in the rat. King, S.J., Miller, H.R., Newlands, G.F., Woodbury, R.G. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  4. Influence of adrenal corticosteroids on the susceptibility of cats to feline leukemia virus infection. Rojko, J.L., Hoover, E.A., Mathes, L.E., Krakowka, S., Olsen, R.G. Cancer Res. (1979) [Pubmed]
  5. Intracellular DNA strand scission and growth inhibition of Ehrlich ascites tumor cells by bleomycins. Byrnes, R.W., Templin, J., Sem, D., Lyman, S., Petering, D.H. Cancer Res. (1990) [Pubmed]
  6. Plasma pharmacokinetics of adriamycin and its metabolites in humans with normal hepatic and renal function. Benjamin, R.S., Riggs, C.E., Bachur, N.R. Cancer Res. (1977) [Pubmed]
  7. Effects of pulse methylprednisolone on bone and marrow tissues: corticosteroid-induced osteonecrosis in rabbits. Yamamoto, T., Irisa, T., Sugioka, Y., Sueishi, K. Arthritis Rheum. (1997) [Pubmed]
  8. Intraarticular injections with methylprednisolone acetate reduce osteoarthritic lesions in parallel with chondrocyte stromelysin synthesis in experimental osteoarthritis. Pelletier, J.P., Mineau, F., Raynauld, J.P., Woessner, J.F., Gunja-Smith, Z., Martel-Pelletier, J. Arthritis Rheum. (1994) [Pubmed]
  9. Treatment of De Quervain's tenosynovitis with corticosteroids. A prospective study of the response to local injection. Anderson, B.C., Manthey, R., Brouns, M.C. Arthritis Rheum. (1991) [Pubmed]
  10. Brainstem stroke following uncomplicated cervical epidural steroid injection. Ziai, W.C., Ardelt, A.A., Llinas, R.H. Arch. Neurol. (2006) [Pubmed]
  11. Adhesive arachnoiditis after lumbar radiculography with Dimer-X and Depo-Medrol. Dullerud, R., Morland, T.J. Radiology. (1976) [Pubmed]
  12. Morphological analysis of knee synovial membrane biopsies from a randomized controlled clinical study comparing the effects of sodium hyaluronate (Hyalgan) and methylprednisolone acetate (Depomedrol) in osteoarthritis. Pasquali Ronchetti, I., Guerra, D., Taparelli, F., Boraldi, F., Bergamini, G., Mori, G., Zizzi, F., Frizziero, L. Rheumatology (Oxford, England) (2001) [Pubmed]
  13. Characterization of infectious crystalline keratitis caused by a human isolate of Streptococcus mitis. McDonnell, P.J., Kwitko, S., McDonnell, J.M., Gritz, D., Trousdale, M.D. Arch. Ophthalmol. (1991) [Pubmed]
  14. Epidural injection of local anesthetic and steroids for relief of pain secondary to herpes zoster. Perkins, H.M., Hanlon, P.R. Archives of surgery (Chicago, Ill. : 1960) (1978) [Pubmed]
  15. Interindividual differences in amitriptyline demethylation. Rollins, D.E., Alván, G., Bertilsson, L., Gillette, J.R., Mellström, B., Sjöqvist, F., Träskman, L. Clin. Pharmacol. Ther. (1980) [Pubmed]
  16. Rectal and oral absorption of methylprednisolone acetate. Garg, D.C., Wagner, J.G., Sakmar, E., Weidler, D.J., Albert, K.S. Clin. Pharmacol. Ther. (1979) [Pubmed]
  17. Hydrolysis of methylprednisolone acetate by human serum cholinesterase. Meyers, C., Lockridge, O., La Du, B.N. Drug Metab. Dispos. (1982) [Pubmed]
  18. Effects of steroids and retinoids on wound healing. Wicke, C., Halliday, B., Allen, D., Roche, N.S., Scheuenstuhl, H., Spencer, M.M., Roberts, A.B., Hunt, T.K. Archives of surgery (Chicago, Ill. : 1960) (2000) [Pubmed]
  19. Effect of methylprednisolone acetate on proteoglycan and collagen metabolism of articular cartilage explants. Todhunter, R.J., Fubini, S.L., Wootton, J.A., Lust, G. J. Rheumatol. (1996) [Pubmed]
  20. Suppression of hyaluronic acid synthesis in synovial organ cultures by corticosteroid suspensions. Myers, S.L. Arthritis Rheum. (1985) [Pubmed]
  21. Effect of intra-articular orgotein versus a corticosteroid on rheumatoid arthritis of the knees. Goebel, K.M., Storck, U. Am. J. Med. (1983) [Pubmed]
  22. Dangers from methylprednisolone acetate therapy by intraspinal injection. Nelson, D.A. Arch. Neurol. (1988) [Pubmed]
  23. The effects of methylprednisolone acetate on macromolecular synthesis and glucose oxidation in epithelial cells of the ocular surface. O'Brien, W.J., Geroski, D.H. Invest. Ophthalmol. Vis. Sci. (1982) [Pubmed]
  24. Study of ansamycin inhibition of a ribonucleic acid-directed deoxyribonucleic acid polymerase by an immobilized template assay. Milavetz, B.I., Horoszewicz, J.S., Rinehart, K.L., Carter, W.A. Antimicrob. Agents Chemother. (1978) [Pubmed]
  25. Methylprednisolone acetate does not cause inflammatory changes in the epidural space. Cicala, R.S., Turner, R., Moran, E., Henley, R., Wong, R., Evans, J. Anesthesiology (1990) [Pubmed]
  26. Properties of redox-inactivated bleomycins. In vitro DNA damage and inhibition of Ehrlich cell proliferation. Templin, J., Berry, L., Lyman, S., Byrnes, R.W., Antholine, W.E., Petering, D.H. Biochem. Pharmacol. (1992) [Pubmed]
  27. Ontogeny of dexamethasone binding and sodium potassium ATPase activity in experimental murine polycystic kidney disease. Ogborn, M.R., Crocker, J.F. J. Steroid Biochem. Mol. Biol. (1991) [Pubmed]
  28. Tacrolimus (FK506) metabolite patterns in blood from liver and kidney transplant patients. Gonschior, A.K., Christians, U., Winkler, M., Linck, A., Baumann, J., Sewing, K.F. Clin. Chem. (1996) [Pubmed]
  29. Serial soluble interleukin 2 receptor levels in rheumatoid arthritis: differences in response to glucocorticoid treatment and chrysotherapy. Kirkham, B.W., Davison, S.C., Corkill, M.M., Barbatis, C., Panayi, G.S. J. Rheumatol. (1993) [Pubmed]
  30. Successful therapy of collagen-induced arthritis with TNF receptor-IgG fusion protein and combination with anti-CD4. Williams, R.O., Ghrayeb, J., Feldmann, M., Maini, R.N. Immunology (1995) [Pubmed]
  31. Copper(II) facilitates bleomycin-mediated unwinding of plasmid DNA. Levy, M.J., Hecht, S.M. Biochemistry (1988) [Pubmed]
  32. CSF and serum concentrations of clozapine and its demethyl metabolite: a pilot study. Nordin, C., Almé, B., Bondesson, U. Psychopharmacology (Berl.) (1995) [Pubmed]
  33. Adrenal regulation of mammary tumorigenesis in female Sprague-Dawley rats: incidence, latency, and yield of mammary tumors. Carter, J.H., Carter, H.W., Meade, J. Cancer Res. (1988) [Pubmed]
  34. Dangers from methylprednisolone acetate therapy by intraspinal injection. Wilkinson, H. Arch. Neurol. (1989) [Pubmed]
  35. A high low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio as a potential risk factor for corticosteroid-induced osteonecrosis in rabbits. Miyanishi, K., Yamamoto, T., Irisa, T., Yamashita, A., Jingushi, S., Noguchi, Y., Iwamoto, Y. Rheumatology (Oxford, England) (2001) [Pubmed]
  36. Methylprednisolone acetate induced release of cartilage proteoglycans: determination by high performance liquid chromatography. Saari, H., Tulamo, R.M., Konttinen, Y.T., Sorsa, T. Ann. Rheum. Dis. (1992) [Pubmed]
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