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Chemical Compound Review

BSPBio_001564     5-hydroxydecanoic acid

Synonyms: KBioGR_000284, KBioSS_000284, ACMC-20mvfk, Lopac0_000628, AC1L1CBO, ...
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Disease relevance of Sodium 5-hydroxydecanoate


High impact information on Sodium 5-hydroxydecanoate

  • When KATP channel antagonists, such as glibenclamide, or the mitochondrial selective inhibitor 5-hydroxydecanoic acid were present during preexposure to morphine, they abolished the protective effect of morphine [4].
  • The protection was blocked with 5-hydroxydecanoic acid (5-HD, 5 mg/kg IV), a relatively selective mitoK(ATP) channel blocker (56.5+/-2.7%), and chelerythrine (5 mg/kg IV), an effective PKC inhibitor (57.1+/-3.4%) administered either on the first day before diazoxide pretreatment or 10 minutes before I/R on the second day [5].
  • Prior to ischaemia, hearts were subjected to pharmacological blockade of the sarcolemmal K(ATP) channel with HMR 1098 (SedHMR and TrHMR), mitochondrial blockade with 5-hydroxydecanoic acid (5HD; Sed5HD and Tr5HD), or perfused with buffer containing no drug (Sed and Tr) [6].
  • The protective effect of this preconditioning is attenuated by 5-hydroxydecanoic acid (5-HD), a selective mitochondrial KATP channel antagonist but not in the presence of HMR-1098, a selective plasma membrane KATP potassium channel antagonist [7].
  • Inhibition of mitochondrial ATP-sensitive K(+) channels by glybenclamide and 5-hydroxydecanoic acid (5-HAD) abolished slow potentials and Ca(2+)-transients, without altering the smooth muscle [Ca(2+)](i) [8].

Chemical compound and disease context of Sodium 5-hydroxydecanoate

  • Glibenclamide or 5-hydroxydecanoic acid (5-HD), when present during the preconditioning hypoxia, blocked the preconditioning effect [9].
  • Celiprolol (1 or 10 mg . kg (-1) . h(-1) for 60 min, iv) was administered 20 min before ischemia with or without pretreatment with N(omega)-nitro-L-arginine methylester (L-NAME, 10 mg/kg, iv, a nitric oxide synthase inhibitor) or 5-hydroxydecanoic acid sodium salt (5-HD, 5 mg/kg, iv, a mitochondrial K(ATP) channel blocker) [10].

Biological context of Sodium 5-hydroxydecanoate


Associations of Sodium 5-hydroxydecanoate with other chemical compounds


Gene context of Sodium 5-hydroxydecanoate

  • The third group was in addition given the nonselective K(ATP) channel antagonist glibenclamide (Glib) 30 min before the ET-1 infusions and the fourth group the selective mitoK(ATP) channel antagonist 5-hydroxydecanoic acid (5-HD) 5 min before I/R [14].

Analytical, diagnostic and therapeutic context of Sodium 5-hydroxydecanoate


  1. Cytochrome P450 omega-hydroxylase inhibition reduces infarct size during reperfusion via the sarcolemmal KATP channel. Gross, E.R., Nithipatikom, K., Hsu, A.K., Peart, J.N., Falck, J.R., Campbell, W.B., Gross, G.J. J. Mol. Cell. Cardiol. (2004) [Pubmed]
  2. The lysophospholipids sphingosine-1-phosphate and lysophosphatidic acid enhance survival during hypoxia in neonatal rat cardiac myocytes. Karliner, J.S., Honbo, N., Summers, K., Gray, M.O., Goetzl, E.J. J. Mol. Cell. Cardiol. (2001) [Pubmed]
  3. Warm ischemic preconditioning improves mitochondrial redox balance during and after mild hypothermic ischemia in guinea pig isolated hearts. An, J., Camara, A.K., Rhodes, S.S., Riess, M.L., Stowe, D.F. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  4. Direct preconditioning of cardiac myocytes via opioid receptors and KATP channels. Liang, B.T., Gross, G.J. Circ. Res. (1999) [Pubmed]
  5. Activation of mitochondrial K(ATP) channel elicits late preconditioning against myocardial infarction via protein kinase C signaling pathway. Takashi, E., Wang, Y., Ashraf, M. Circ. Res. (1999) [Pubmed]
  6. Cardioprotection afforded by chronic exercise is mediated by the sarcolemmal, and not the mitochondrial, isoform of the KATP channel in the rat. Brown, D.A., Chicco, A.J., Jew, K.N., Johnson, M.S., Lynch, J.M., Watson, P.A., Moore, R.L. J. Physiol. (Lond.) (2005) [Pubmed]
  7. Activation of mitochondrial ATP-sensitive potassium channels increases cell viability against rotenone-induced cell death. Tai, K.K., McCrossan, Z.A., Abbott, G.W. J. Neurochem. (2003) [Pubmed]
  8. Spontaneous electrical activity and associated changes in calcium concentration in guinea-pig gastric smooth muscle. Fukuta, H., Kito, Y., Suzuki, H. J. Physiol. (Lond.) (2002) [Pubmed]
  9. Direct preconditioning of cardiac ventricular myocytes via adenosine A1 receptor and KATP channel. Liang, B.T. Am. J. Physiol. (1996) [Pubmed]
  10. Celiprolol, a Selective beta1-Blocker, Reduces the Infarct Size Through Production of Nitric Oxide in a Rabbit Model of Myocardial Infarction. Chen, X., Minatoguchi, S., Arai, M., Wang, N., Lu, C., Narentuoya, B., Uno, Y., Misao, Y., Takemura, G., Fujiwara, T., Fujiwara, H. Circ. J. (2007) [Pubmed]
  11. Distinct roles for sarcolemmal and mitochondrial adenosine triphosphate-sensitive potassium channels in isoflurane-induced protection against oxidative stress. Marinovic, J., Bosnjak, Z.J., Stadnicka, A. Anesthesiology (2006) [Pubmed]
  12. Isoflurane preconditioning protects motor neurons from spinal cord ischemia: its dose-response effects and activation of mitochondrial adenosine triphosphate-dependent potassium channel. Park, H.P., Jeon, Y.T., Hwang, J.W., Kang, H., Lim, S.W., Kim, C.S., Oh, Y.S. Neurosci. Lett. (2005) [Pubmed]
  13. Sevoflurane-induced preconditioning of rat brain in vitro and the role of KATP channels. Kehl, F., Payne, R.S., Roewer, N., Schurr, A. Brain Res. (2004) [Pubmed]
  14. Endothelin-1 exerts a preconditioning-like cardioprotective effect against ischaemia/reperfusion injury via the ET(A) receptor and the mitochondrial K(ATP) channel in the rat in vivo. Gourine, A.V., Molosh, A.I., Poputnikov, D., Bulhak, A., Sjöquist, P.O., Pernow, J. Br. J. Pharmacol. (2005) [Pubmed]
  15. Fructose-fed rats are protected against ischemia/reperfusion injury. Jordan, J.E., Simandle, S.A., Tulbert, C.D., Busija, D.W., Miller, A.W. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  16. Activation of mitochondrial ATP-sensitive potassium channels prevents neuronal cell death after ischemia in neonatal rats. Rajapakse, N., Shimizu, K., Kis, B., Snipes, J., Lacza, Z., Busija, D. Neurosci. Lett. (2002) [Pubmed]
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