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MeSH Review

Cold Ischemia

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Disease relevance of Cold Ischemia


High impact information on Cold Ischemia


Chemical compound and disease context of Cold Ischemia


Biological context of Cold Ischemia


Anatomical context of Cold Ischemia


Associations of Cold Ischemia with chemical compounds

  • This endogenous protective mechanism is capable of blocking xanthine/XOD generation in liver grafts during cold ischemia [26].
  • The addition of U74006F to University of Wisconsin preservation solution significantly prolonged endothelial cell viability after 48 and 72 hr of cold ischemia and reoxygenation (p < 0.01) [27].
  • The following experimental groups were studied: I, cold ischemia; I+X, effect of xanthine; I+T, effect of adenosine (blocking its receptor by theophylline); I+A, effect of excess adenosine; I+T+X, effect of xanthine alone, and I+T+ spermine NONOate (NONOs), I+A+NONOs, I+X+NONOs, role of NO [28].
  • The study objective was to assess hepatic utilization of exogenous adenosine or adenine to enhance ATP recovery in rat liver after cold ischemia [29].
  • In a multivariate regression model, donor age and recipient creatinine were observed to be significant covariates in both groups, while donor race, cold ischemia time (CIT), female to male transplants, and recipient albumin were independent predictors of survival of HCV- recipients [30].

Gene context of Cold Ischemia

  • Interleukin-10 plasma levels did not correlate either with cold ischemia time or with the occurrence of rejection episodes [31].
  • CINC mRNA also increased as cold-ischemia time was prolonged [32].
  • The W/D ratio and myeloperoxidase decreased in both 24- and 48-hour groups, with TGF-beta1-active compared with CAT, and 18-hour cold ischemia groups (W/D, p < 0.02 and p < 0.004, respectively; myeloperoxidase, p < 0.05 and p < 0.01, respectively) [33].
  • Multiple regression revealed a significant correlation between cold ischemia time and posttransplant urinary FBPase excretion (multiple R = 0.65, p < 0.001) [34].
  • In renal grafts with pretransplantation cold ischemia and subsequent ischemia-reperfusion injury, overactivation of PARP-1 may lead to a higher index of acute tubular necrosis, a delay in total recovery of the function of the transplanted organ, and an early progression to chronic graft nephropathy [35].

Analytical, diagnostic and therapeutic context of Cold Ischemia


  1. Immunotargeting of catalase to the pulmonary endothelium alleviates oxidative stress and reduces acute lung transplantation injury. Kozower, B.D., Christofidou-Solomidou, M., Sweitzer, T.D., Muro, S., Buerk, D.G., Solomides, C.C., Albelda, S.M., Patterson, G.A., Muzykantov, V.R. Nat. Biotechnol. (2003) [Pubmed]
  2. Metabolism of hyaluronic acid by liver endothelial cells: effect of ischemia-reperfusion in the isolated perfused rat liver. Sutto, F., Brault, A., Lepage, R., Huet, P.M. J. Hepatol. (1994) [Pubmed]
  3. The correlation between donor characteristics and the success of human islet isolation. Zeng, Y., Torre, M.A., Karrison, T., Thistlethwaite, J.R. Transplantation (1994) [Pubmed]
  4. Donor heme oxygenase-1 genotype is associated with renal allograft function. Exner, M., Böhmig, G.A., Schillinger, M., Regele, H., Watschinger, B., Hörl, W.H., Raith, M., Mannhalter, C., Wagner, O.F. Transplantation (2004) [Pubmed]
  5. Ischemia times and donor serum creatinine in relation to renal graft failure. Roodnat, J.I., Mulder, P.G., Van Riemsdijk, I.C., IJzermans, J.N., van Gelder, T., Weimar, W. Transplantation (2003) [Pubmed]
  6. Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury. Amersi, F., Buelow, R., Kato, H., Ke, B., Coito, A.J., Shen, X.D., Zhao, D., Zaky, J., Melinek, J., Lassman, C.R., Kolls, J.K., Alam, J., Ritter, T., Volk, H.D., Farmer, D.G., Ghobrial, R.M., Busuttil, R.W., Kupiec-Weglinski, J.W. J. Clin. Invest. (1999) [Pubmed]
  7. Evidence for the detrimental role of proteolysis during liver preservation in humans. Calmus, Y., Cynober, L., Dousset, B., Lim, S.K., Soubrane, O., Conti, F., Houssin, D., Giboudeau, J. Gastroenterology (1995) [Pubmed]
  8. Role of Kupffer cells in cold ischemia/reperfusion injury of rat liver. Imamura, H., Sutto, F., Brault, A., Huet, P.M. Gastroenterology (1995) [Pubmed]
  9. Calpain is a mediator of preservation-reperfusion injury in rat liver transplantation. Kohli, V., Gao, W., Camargo, C.A., Clavien, P.A. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  10. Nitroglycerin improves functional recovery of neonatal lamb hearts after 2 hours of cold ischemia. Kawata, H., Aoki, M., Mayer, J.E. Circulation (1993) [Pubmed]
  11. Pharmacokinetics of methylprednisolone and rejection episodes in kidney transplant patients. Keller, F., Hemmen, T., Schöneshöfer, M., Schwarz, A., Offermann, G. Transplantation (1995) [Pubmed]
  12. Warm ischemic preconditioning improves mitochondrial redox balance during and after mild hypothermic ischemia in guinea pig isolated hearts. An, J., Camara, A.K., Rhodes, S.S., Riess, M.L., Stowe, D.F. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  13. Pathophysiological mechanisms of postrevascularization hyperkalemia in orthotopic liver transplantation. Nakasuji, M., Bookallil, M.J. Anesth. Analg. (2000) [Pubmed]
  14. Cardioplegia and ischemia in the canine heart evaluated by 31P magnetic resonance spectroscopy. Torchiana, D.F., Vine, A.J., Shebani, K.O., Kantor, H.L., Titus, J.S., Lu, C.Z., Daggett, W.M., Geffin, G.A. Ann. Thorac. Surg. (2000) [Pubmed]
  15. Effect of glycine on isolated, perfused rabbit livers following 48-hour preservation in University of Wisconsin solution without glutathione. den Butter, G., Marsh, D.C., Lindell, S.L., Belzer, F.O., Southard, J.H. Transpl. Int. (1994) [Pubmed]
  16. Calcium antagonists and acute renal failure. Russell, J.D., Churchill, D.N. Am. J. Med. (1989) [Pubmed]
  17. DNA/dendrimer complexes mediate gene transfer into murine cardiac transplants ex vivo. Wang, Y., Boros, P., Liu, J., Qin, L., Bai, Y., Bielinska, A.U., Kukowska-Latallo, J.F., Baker, J.R., Bromberg, J.S. Mol. Ther. (2000) [Pubmed]
  18. Dynamic in vivo observation of villus microcirculation during small bowel autotransplantation: effects of endothelin-A receptor inhibition. Wolfárd, A., Szalay, L., Kaszaki, J., Sahin-Tóth, G., Vangel, R., Balogh, A., Boros, M. Transplantation (2002) [Pubmed]
  19. Mechanisms of coronary vasomotor dysfunction in the transplanted heart. Fullerton, D.A., Mitchell, M.B., McIntyre, R.C., Brown, J.M., Meng, X., Campbell, D.N., Grover, F.L. Ann. Thorac. Surg. (1994) [Pubmed]
  20. Protective effects of exogenous fructose-1,6-biphosphate during small bowel transplantation in rats. Sola, A., De Oca, J., Alfaro, V., Xaus, C., Jaurrieta, E., Hotter, G. Surgery (2004) [Pubmed]
  21. Effect of antibody to leukocyte adhesion molecule CD18 on recovery of neonatal lamb hearts after 2 hours of cold ischemia. Kawata, H., Aoki, M., Hickey, P.R., Mayer, J.E. Circulation (1992) [Pubmed]
  22. Direct visualization of cortical peritubular capillary of transplanted human kidney with reperfusion injury using a magnifying endoscopy. Hattori, R., Ono, Y., Kato, M., Komatsu, T., Matsukawa, Y., Yamamoto, T. Transplantation (2005) [Pubmed]
  23. Effects of a novel 21-aminosteroid or methylprednisolone in experimental total intestinal ischemia. Park, P.O., Gerdin, B., Haglund, U. Archives of surgery (Chicago, Ill. : 1960) (1994) [Pubmed]
  24. Pancreas prostanoid production in ischemia and reperfusion. Hotter, G., Roselló-Catafau, J., Closa, D., Bulbena, O., López-Boado, M.A., Fernández-Cruz, L., Gelpi, E. Prostaglandins (1992) [Pubmed]
  25. Improvement of rat lung structure and function after preservation with celsior. Fehrenbach, A., Wittwer, T., Cornelius, J., Ochs, M., Fehrenbach, H., Wahlers, T., Richter, J. J. Surg. Res. (1999) [Pubmed]
  26. Preconditioning protects liver and lung damage in rat liver transplantation: role of xanthine/xanthine oxidase. Fernández, L., Heredia, N., Grande, L., Gómez, G., Rimola, A., Marco, A., Gelpí, E., Roselló-Catafau, J., Peralta, C. Hepatology (2002) [Pubmed]
  27. Protective effect of the lazaroid U74006F in cold ischemia-reperfusion injury of the liver. Cosenza, C.A., Cramer, D.V., Cunneen, S.A., Tuso, P.J., Wang, H.K., Makowka, L. Hepatology (1994) [Pubmed]
  28. Role of changes in tissular nucleotides on the development of apoptosis during ischemia/reperfusion in rat small bowel. Genescà, M., Sola, A., Miquel, R., Pi, F., Xaus, C., Alfaro, V., Hotter, G. Am. J. Pathol. (2002) [Pubmed]
  29. Hepatic utilization of exogenous nucleotide precursors for restoration of ATP after cold ischemia in rats. Palombo, J.D., Bowers, J.L., Clouse, M.E., McCullough, A., Forse, R.A., Bistrian, B.R. Am. J. Clin. Nutr. (1993) [Pubmed]
  30. Factors differentially correlated with the outcome of liver transplantation in hcv+ and HCV- recipients. Velidedeoglu, E., Mange, K.C., Frank, A., Abt, P., Desai, N.M., Markmann, J.W., Reddy, R., Markmann, J.F. Transplantation (2004) [Pubmed]
  31. Systemic release of interleukin-10 during orthotopic liver transplantation. Le Moine, O., Marchant, A., Durand, F., Ickx, B., Pradier, O., Belghiti, J., Abramowicz, D., Gelin, M., Goldman, M., Devière, J. Hepatology (1994) [Pubmed]
  32. Effect of cold-ischemia time on C-X-C chemokine expression and neutrophil accumulation in the graft liver after orthotopic liver transplantation in rats. Kataoka, M., Shimizu, H., Mitsuhashi, N., Ohtsuka, M., Wakabayashi, Y., Ito, H., Kimura, F., Nakagawa, K., Yoshidome, H., Shimizu, Y., Miyazaki, M. Transplantation (2002) [Pubmed]
  33. Recipient intramuscular administration of naked plasmid TGF-beta1 attenuates lung graft reperfusion injury. Daddi, N., Kanaan, S.A., Suda, T., Tagawa, T., D'Ovidio, F., Grapperhaus, K., Kozower, B.D., Ritter, J.H., Mohanakumar, T., Patterson, G.A. J. Heart Lung Transplant. (2003) [Pubmed]
  34. Graft ischemia correlates with urinary excretion of the proximal marker enzyme fructose-1,6-bisphosphatase in human kidney transplantation. Kotanko, P., Margreiter, R., Pfaller, W. Nephron (1997) [Pubmed]
  35. Correlation of morphological findings with functional reserve in the aging donor: role of the poly (ADP-ribose) polymerase. O'Valle, F., Benitez, M.C., Gómez-Morales, M., Bravo, J., Osuna, A., del Moral, R.M., Martin-Oliva, D., Oliver, F.J., del Moral, R.G. Transplant. Proc. (2004) [Pubmed]
  36. Cold ischemia induces isograft arteriopathy, but does not augment allograft arteriopathy in non-immunosuppressed hosts. Furukawa, Y., Libby, P., Stinn, J.L., Becker, G., Mitchell, R.N. Am. J. Pathol. (2002) [Pubmed]
  37. Adenine nucleotide metabolism and its relation to organ viability in human liver transplantation. Kamiike, W., Burdelski, M., Steinhoff, G., Ringe, B., Lauchart, W., Pichlmayr, R. Transplantation (1988) [Pubmed]
  38. Factors contributing to the development of chronic rejection in heterotopic rat heart transplantation. Schmid, C., Heemann, U., Tilney, N.L. Transplantation (1997) [Pubmed]
  39. Evaluation of eight preservation solutions for endothelial in situ preservation. Wilson, C.H., Stansby, G., Haswell, M., Cunningham, A.C., Talbot, D. Transplantation (2004) [Pubmed]
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