Disease relevance of aceclidine

• 3 This reduced sensitivity to light was accompanied by an overshoot of the resting pupil diameter and, after aceclidine miosis, a reduced response to a second application of miotic [1].
• When peripheral muscarinic activity was blocked by administration of methylscopolamine, a dose-dependent hypertension was obtained following the injection of oxotremorine, arecoline and aceclidine, by both intraperitoneal and intracerebroventricular routes [2].

High impact information on aceclidine

• The agents (+)- and (-)-aceclidine (3-acetoxyquinuclidine), (+)- and (-)-N-methylaceclidine, and oxotremorine were compared in their ability to inhibit specific 3H-labeled (+/-)-3-quinuclidinyl benzilate binding to rat brain muscarinic receptors and to stimulate contractions of the isolated guinea pig ileum [3].
• The pharmacological activity of the enantiomers of aceclidine was investigated in Chinese hamster ovary cells transfected with the M1 through M5 subtypes of the muscarinic receptor and also in the rat heart and parotid gland that express primarily M2 and M3 receptors, respectively [4].
• Thirty minutes after the instillation of diluted aceclidine, the topography-derived wavefront error showed a statistically significant reduction in RMS values (total, spherical, astigmatic, coma, and higher order), which was maintained for 5 hours [5].
• The tonic activity of the muscarinic agonists, aceclidine, arecoline, carbachol, McN-A-343, RS 86, thiopilocarpine and WAL 2014 FU, was tested in groups of isolated tracheal muscle of the guinea-pig [6].
• We sought to determine if different muscarinic receptor subtypes control outflow facility, accommodative and pupillary responses to aceclidine in the living rhesus monkey eye, as a possible basis for this separation [7].

Biological context of aceclidine

• Our results demonstrated that no differences in timolol and aceclidine bioavailability were found between simple-drug preparations and their combination [8].

Anatomical context of aceclidine

• Aceclidine has negligible side effects on the ocular components (maximal change of the anterior chamber 0.20 mm; maximal change of the lens thickness 0.14 mm; maximal myopisation: -1.5 delta [9].
• To determine whether this dissociation resides in the ciliary muscle (CM) or trabecular meshwork (TM), we measured aceclidine effects on perfusion outflow facility in both eyes of 8 rhesus monkeys after unilateral disinsertion of the CM from the TM [10].

Associations of aceclidine with other chemical compounds

• The M3 muscarinic receptor subtype antagonist 4-DAMP was the most potent inhibitor of all three responses to aceclidine [7].
• Ultrasonographic comparative study of the effect of pilocarpine and aceclidine on the eye components [11].
• Iontophoresis of acetylcholine, aceclidine (a cholinomimetic drug), or intracellularly applied cyclic GMP produces changes in single neuron membrane resistance that increase neuronal excitability [12].

Analytical, diagnostic and therapeutic context of aceclidine

• Aceclidine was assayed by a pharmacodynamic method: pupillary diameter at the following time intervals 0 (basal value), 1 min, 5 min, 30 min, 1 hr, 2 hr, 4 hr, 6 hr after treatment [8].

References