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Chemical Compound Review

AG-K-66598     2,3,4,5- tetrahydroxypentoxyphosphonic acid

Synonyms: CHEMBL1161476, AC1Q6RYK, CTK1H2228, AR-1C5018, AC1L1D6U, ...
 
 
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Disease relevance of polyribitol phosphate

 

High impact information on polyribitol phosphate

 

Chemical compound and disease context of polyribitol phosphate

 

Biological context of polyribitol phosphate

  • Unconjugated polyribosylribitolphosphate (PRP) was not immunogenic; PRP-D conjugate produced a low antibody response, HbOC, PRP-T (Merieux) and Hib-T (MPHBL) produced a low response to the first dose and a strong anamnestic response to the booster dose [9].
 

Anatomical context of polyribitol phosphate

 

Associations of polyribitol phosphate with other chemical compounds

  • The B cell responses induced by PRP and LPS were similar with respect to T cell and A cell independence, to the magnitude of DNA synthesis, and to Ig secretion and the Ig isotypes expressed [7].
  • Coating with avidin or streptavidin followed by incubation with biotin-coupled PRP was not satisfactory either, due to binding of certain sera in the absence of PRP [13].
  • IgG-anti-Hib labelled with horseradish peroxidase then links to PRP; the enzyme activity is measured by oxidation of the chromogenic substrate o-phenylenediamine [12].
 

Gene context of polyribitol phosphate

  • However, the finding that the binding of a few sera was only partially inhibited by soluble PRP led us to include an inhibition step in every experiment [13].
 

Analytical, diagnostic and therapeutic context of polyribitol phosphate

References

  1. Antibacterial activity of a human monoclonal antibody to haemophilus influenzae type B capsular polysaccharide. Hunter, K.W., Fischer, G.W., Hemming, V.G., Wilson, S.R., Hartzman, R.J., Woody, J.N. Lancet (1982) [Pubmed]
  2. Pseudo-allelic relationship between non-homologous genes concerned with biosynthesis of polyglycerol phosphate and polyribitol phosphate teichoic acids in Bacillus subtilis strains 168 and W23. Young, M., Mauël, C., Margot, P., Karamata, D. Mol. Microbiol. (1989) [Pubmed]
  3. Relationship between naturally occurring human mucosal and serum antibody to the capsular polysaccharide of Haemophilus influenzae type b. Pichichero, M.E., Insel, R.A. J. Infect. Dis. (1982) [Pubmed]
  4. Antibody response to Haemophilus influenzae type b vaccine in relation to the number of CD4+ T lymphocytes in adults infected with human immunodeficiency virus. Kroon, F.P., van Dissel, J.T., Rijkers, G.T., Labadie, J., van Furth, R. Clin. Infect. Dis. (1997) [Pubmed]
  5. Detection of Haemophilus influenzae type b antigenuria by Bactigen and Phadebact kits. Riera, L. J. Clin. Microbiol. (1985) [Pubmed]
  6. Subclass distribution of human antibodies to Haemophilus influenzae type b capsular polysaccharide. Shackelford, P.G., Granoff, D.M., Nelson, S.J., Scott, M.G., Smith, D.S., Nahm, M.H. J. Immunol. (1987) [Pubmed]
  7. The type-specific capsular carbohydrate of Hemophilus influenzae B is a potent mitogen for murine B lymphocytes. Lucas, A.H., Asser, S.M. J. Immunol. (1986) [Pubmed]
  8. A polysaccharide-protein complex from Haemophilus influenzae type b. I. Activity in weanling rabbits and human T lymphocytes. Anderson, P., Insel, R.A. J. Infect. Dis. (1981) [Pubmed]
  9. Development of a guinea-pig model for potency/immunogenicity evaluation of diphtheria, tetanus acellular pertussis (DTaP) and Haemophilus influenzae type b polysaccharide conjugate vaccines. Gupta, R.K., Anderson, R., Cecchini, D., Rost, B., Griffin, P., Benscoter, K., Xu, J., Montanez-Ortiz, L., Siber, G.R. Dev. Biol. Stand. (1996) [Pubmed]
  10. In vitro system for the synthesis of teichoic acid linked to peptidoglycan. Bracha, R., Glaser, L. J. Bacteriol. (1976) [Pubmed]
  11. The binding of Pneumococcal lipoteichoic acid to human erythrocytes. McCloskey, J.J., Szombathy, S., Swift, A.J., Conrad, D., Winkelstein, J.A. Microb. Pathog. (1993) [Pubmed]
  12. Quantitation of Haemophilus influenzae serotype b capsular polysaccharide antigen in body fluids by enzyme immunoassay. Henne, G., Tiller, F.W., Diener, E. Biomed. Biochim. Acta (1984) [Pubmed]
  13. Measurement of anti-Haemophilus influenzae type b capsular polysaccharide antibodies by ELISA. Barra, A., Schulz, D., Aucouturier, P., Preud'homme, J.L. J. Immunol. Methods (1988) [Pubmed]
 
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