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Chemical Compound Review

Orthamine     benzene-1,2-diamine

Synonyms: OPDA, PODA, SureCN6187, CCRIS 508, CHEMBL70582, ...
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Disease relevance of o-Phenylene diamine


High impact information on o-Phenylene diamine

  • In these novel core-shell ensembles (7 and 19), either an efficient energy transfer from the dialkoxyanthracene periphery, or an electron transfer from the o-phenylene diamine periphery transduces the flow of excited-state energy or electrons, respectively, to the fullerene moiety, which resides in the central core [3].
  • They are mechanistically investigated with atomic force microscopy techniques (AFM) on six different faces of 1 when o-phenylenediamine was the reagent (substitution, elimination, cyclization, elimination) and interpreted on the basis of known crystal structure data [4].
  • Rat H-TGL was detected by the color development after the addition of 0.4 mg/ml of o-phenylenediamine in 0.01% H2O2, 0.1 M citrate phosphate, pH 5 [5].
  • The enzymes also catalyse the oxidation of pyrogallol, o-phenylenediamine and I- to I3-. Preliminary characterization of these enzymes reveals acidic pH optima, high thermal stability, sensitivity to higher H2O2 concentrations, and apparent molecular weights ranging from 48000 to 60000 [6].
  • In the assay specific antibody covalently bonded to latex particles is used, along with horseradish peroxidase as the label, and o-phenylenediamine as the chromogen [7].

Biological context of o-Phenylene diamine


Anatomical context of o-Phenylene diamine


Associations of o-Phenylene diamine with other chemical compounds


Gene context of o-Phenylene diamine

  • The serum oxidation activity (SOA) of patients with rheumatoid arthritis (RA) and other connective-tissue diseases (OCTD) was measured by a new colorimetric procedure the authors have devised, using o-phenylene diamine (OPD) as the indicator [23].
  • The stained IL-1 bands were cut out, exposed to the peroxidase chromogenic substrate, o-phenylenediamine (OPD), and hydrogen peroxide and the rate of reaction was determined spectrophotometrically at 490 nM [24].
  • After blocking any further adsorption to the plate, standards or diluted patient samples were added for a 5-h incubation at room temperature, after which the plate was washed and antibody-bound SHBG was detected with an anti-SHBG IgG1 monoclonal antibody followed by peroxidase-labeled antimouse-IgG1 and o-phenylenediamine substrate [25].
  • A second MoAb (528) binds to the immobilized EGFR and is revealed with o-phenylenediamine by a peroxidase-linked goat antimouse IgG2a [26].
  • The biotinylated CEA bound to the immobilized antibody were then reacted with avidin-peroxidase conjugate and the activity of the bound peroxidase was determined by the use of o-phenylenediamine and hydrogen peroxidase [27].

Analytical, diagnostic and therapeutic context of o-Phenylene diamine


  1. Sensitive detection of a plant virus by electrochemical enzyme-linked immunoassay. Jiao, K., Sun, W., Zhang, S.S. Fresenius' journal of analytical chemistry. (2000) [Pubmed]
  2. A new label-free amperometric immunosenor for rubella vaccine. Zhang, L., Yuan, R., Huang, X., Chai, Y., Tang, D., Cao, S. Analytical and bioanalytical chemistry. (2005) [Pubmed]
  3. T(h)-symmetrical hexakisadducts of C(60) with a densely packed pi-donor shell can act as energy- or electron-transducing systems. Diekers, M., Luo, C., Guldi, D.M., Hirsch, A. Chemistry (Weinheim an der Bergstrasse, Germany) (2002) [Pubmed]
  4. Quantitative reaction cascades of ninhydrin in the solid state. Kaupp, G., Naimi-Jamal, M.R., Schmeyers, J. Chemistry (Weinheim an der Bergstrasse, Germany) (2002) [Pubmed]
  5. Enzyme-linked immunosorbent assay for rat hepatic triglyceride lipase. Cisar, L.A., Bensadoun, A. J. Lipid Res. (1985) [Pubmed]
  6. Bromoperoxidases from Penicillus capitatus, Penicillus lamourouxii and Rhipocephalus phoenix. Baden, D.G., Corbett, M.D. Biochem. J. (1980) [Pubmed]
  7. A sensitive manual enzyme immunoassay for thyroxine. Schall, R.F., Fraser, A.S., Hansen, H.W., Kern, C.W., Tenoso, H.J. Clin. Chem. (1978) [Pubmed]
  8. An in vitro mucosal model predictive of bioadhesive agents in the oral cavity. Patel, D., Smith, A.W., Grist, N., Barnett, P., Smart, J.D. Journal of controlled release : official journal of the Controlled Release Society. (1999) [Pubmed]
  9. o-Phenylenediamine-induced DNA damage and mutagenicity in tobacco seedlings is light-dependent. Gichner, T., Stavreva, D.A., Van Breusegem, F. Mutat. Res. (2001) [Pubmed]
  10. Correlations between DNA and cytogenetic damage induced after chemical treatment and radiation. Cebulska-Wasilewska, A., Nowak, D., Niedźwiedź, W., Anderson, D. Mutat. Res. (1998) [Pubmed]
  11. Mutagenic interactions between X-rays and two promutagens, o-phenylenediamine and N-nitrosodimethylamine, in the stamen hairs of Tradescantia clone BNL 4430. Xiao, L.Z., Ichikawa, S. Mutat. Res. (1998) [Pubmed]
  12. Detection of alpha-dicarbonyl compounds in Maillard reaction systems and in vivo. Glomb, M.A., Tschirnich, R. J. Agric. Food Chem. (2001) [Pubmed]
  13. Detection of Cryptosporidium parvum oocysts in bovine feces by monoclonal antibody capture enzyme-linked immunosorbent assay. Anusz, K.Z., Mason, P.H., Riggs, M.W., Perryman, L.E. J. Clin. Microbiol. (1990) [Pubmed]
  14. Induction of somatic mutations in Tradescantia clone 4430 by three phenylenediamine isomers and the antimutagenic mechanisms of diethyldithiocarbamate and ammonium meta-vanadate. Gichner, T., Cabrera Lopez, G., Wagner, E.D., Plewa, M.J. Mutat. Res. (1994) [Pubmed]
  15. The induction of eosinophil peroxidase release: improved methods of measurement and stimulation. Adamko, D.J., Wu, Y., Gleich, G.J., Lacy, P., Moqbel, R. J. Immunol. Methods (2004) [Pubmed]
  16. Nitric oxide reduces blood pressure in the nucleus tractus solitarius: a real time electrochemical study. Wu, W.C., Wang, Y., Kao, L.S., Tang, F.I., Chai, C.Y. Brain Res. Bull. (2002) [Pubmed]
  17. A miniaturized Nafion-based glucose sensor: in vitro and in vivo evaluation in dogs. Moussy, F., Harrison, D.J., Rajotte, R.V. The International journal of artificial organs. (1994) [Pubmed]
  18. Histogranin-like antinociceptive and anti-inflammatory derivatives of o-phenylenediamine and benzimidazole. Le, H.T., Lemaire, I.B., Gilbert, A.K., Jolicoeur, F., Yang, L., Leduc, N., Lemaire, S. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  19. 2,3-Diaminophenazine is the product from the horseradish peroxidase-catalyzed oxidation of o-phenylenediamine. Tarcha, P.J., Chu, V.P., Whittern, D. Anal. Biochem. (1987) [Pubmed]
  20. Liquid chromatographic and fluorescent derivative aerobic degradation studies of dehydroascorbic acid in aqueous solution at elevated temperatures. Hughes, D.E., Van Deusen, S. The Analyst. (1989) [Pubmed]
  21. DNA damage induced by indirect and direct acting mutagens in catalase-deficient transgenic tobacco. Cellular and acellular Comet assays. Gichner, T. Mutat. Res. (2003) [Pubmed]
  22. Gamma irradiation as a substitute for H2O2 in peroxidase-labelled enzyme immunoassays. Schuler, G., Kuphal, K., Khalaf, A.N., Petersen, K.G., Kerp, L. J. Immunol. Methods (1989) [Pubmed]
  23. Serum oxidation activities and rheumatoid arthritis. Nakamura, K., Endo, H., Kashiwazaki, S. International journal of tissue reactions. (1987) [Pubmed]
  24. Quantitation of related proteins by Western blot analysis. Uhl, J., Newton, R.C. J. Immunol. Methods (1988) [Pubmed]
  25. Monoclonal antibodies to human sex hormone-binding globulin (SHBG): characterization and use in a simple enzyme-linked immunosorbent assay (ELISA) of SHBG in plasma. Lewis, J.G., Longley, N.J., Elder, P.A. Steroids (1999) [Pubmed]
  26. Immunoenzymetric assay of epidermal growth factor receptor. Application to breast tumor samples. Grimaux, M., Lainé-Bidron, C., Magdelénat, H. Tumour Biol. (1989) [Pubmed]
  27. Determination of epitope specificities of a large number of monoclonal antibodies by solid-phase mutual inhibition assays using biotinylated antigen. Kuroki, M., Wakisaka, M., Murakami, M., Haruno, M., Arakawa, F., Higuchi, H., Matsuoka, Y. Immunol. Invest. (1992) [Pubmed]
  28. Synthesis and hybridization of a series of biotinylated oligonucleotides. Cook, A.F., Vuocolo, E., Brakel, C.L. Nucleic Acids Res. (1988) [Pubmed]
  29. Glucose fast-response amperometric sensor based on glucose oxidase immobilized in an electropolymerized poly(o-phenylenediamine) film. Malitesta, C., Palmisano, F., Torsi, L., Zambonin, P.G. Anal. Chem. (1990) [Pubmed]
  30. Fluorescent analysis of alpha-keto acids in serum and urine by high-performance liquid chromatography. Koike, K., Koike, M. Anal. Biochem. (1984) [Pubmed]
  31. Investigation of disulfonamide ligands derived from o-phenylenediamine and their Pb(II) complexes by electrospray ionization mass spectrometry. Zhang, W., Cai, Y., Kavallieratos, K. Rapid Commun. Mass Spectrom. (2006) [Pubmed]
  32. Nicotine-evoked nitric oxide release in the rat hippocampal slice. Smith, D.A., Hoffman, A.F., David, D.J., Adams, C.E., Gerhardt, G.A. Neurosci. Lett. (1998) [Pubmed]
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