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Chemical Compound Review

Orthamine     benzene-1,2-diamine

Synonyms: OPDA, PODA, SureCN6187, CCRIS 508, CHEMBL70582, ...
 
 
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Disease relevance of o-Phenylene diamine

 

High impact information on o-Phenylene diamine

  • In these novel core-shell ensembles (7 and 19), either an efficient energy transfer from the dialkoxyanthracene periphery, or an electron transfer from the o-phenylene diamine periphery transduces the flow of excited-state energy or electrons, respectively, to the fullerene moiety, which resides in the central core [3].
  • They are mechanistically investigated with atomic force microscopy techniques (AFM) on six different faces of 1 when o-phenylenediamine was the reagent (substitution, elimination, cyclization, elimination) and interpreted on the basis of known crystal structure data [4].
  • Rat H-TGL was detected by the color development after the addition of 0.4 mg/ml of o-phenylenediamine in 0.01% H2O2, 0.1 M citrate phosphate, pH 5 [5].
  • The enzymes also catalyse the oxidation of pyrogallol, o-phenylenediamine and I- to I3-. Preliminary characterization of these enzymes reveals acidic pH optima, high thermal stability, sensitivity to higher H2O2 concentrations, and apparent molecular weights ranging from 48000 to 60000 [6].
  • In the assay specific antibody covalently bonded to latex particles is used, along with horseradish peroxidase as the label, and o-phenylenediamine as the chromogen [7].
 

Biological context of o-Phenylene diamine

 

Anatomical context of o-Phenylene diamine

 

Associations of o-Phenylene diamine with other chemical compounds

 

Gene context of o-Phenylene diamine

  • The serum oxidation activity (SOA) of patients with rheumatoid arthritis (RA) and other connective-tissue diseases (OCTD) was measured by a new colorimetric procedure the authors have devised, using o-phenylene diamine (OPD) as the indicator [23].
  • The stained IL-1 bands were cut out, exposed to the peroxidase chromogenic substrate, o-phenylenediamine (OPD), and hydrogen peroxide and the rate of reaction was determined spectrophotometrically at 490 nM [24].
  • After blocking any further adsorption to the plate, standards or diluted patient samples were added for a 5-h incubation at room temperature, after which the plate was washed and antibody-bound SHBG was detected with an anti-SHBG IgG1 monoclonal antibody followed by peroxidase-labeled antimouse-IgG1 and o-phenylenediamine substrate [25].
  • A second MoAb (528) binds to the immobilized EGFR and is revealed with o-phenylenediamine by a peroxidase-linked goat antimouse IgG2a [26].
  • The biotinylated CEA bound to the immobilized antibody were then reacted with avidin-peroxidase conjugate and the activity of the bound peroxidase was determined by the use of o-phenylenediamine and hydrogen peroxidase [27].
 

Analytical, diagnostic and therapeutic context of o-Phenylene diamine

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