The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

xylamidine     N'-[2-(3- methoxyphenoxy)propyl]-2- (3...

Synonyms: SureCN2107805, LS-176376, PDSP1_001352, PDSP2_001336, AC1L2LD3, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of xylamidine


High impact information on xylamidine

  • This effect was inhibited by non-selective 5-HT2 receptor antagonists (methysergide, LY53857, LY215840), by a peripherally restricted 5-HT2 receptor antagonist (xylamidine) and by a 5-HT2B selective receptor antagonist (LY202146) [3].
  • Pretreatment with xylamidine tosylate, a 5-HT2 receptor antagonist that does not cross the blood-brain barrier, blocked the pressor response to i.v., but not i.c.v., administration of equivalent doses of DOI [4].
  • Xylamidine produced a shift to the right and suppression of the maximal effect of DOI on plasma renin activity, suggesting a role for peripheral 5-HT2 receptors in the effect of DOI [5].
  • To evaluate the role of central nervous system (CNS) 5-HT(2A) receptors in TST regulation, DOI was administered in combination with a known peripheral 5-HT(2A/2C) receptor antagonist, xylamidine, in the MD model [6].
  • In addition, the peripheral 5-HT2 receptor antagonist, xylamidine, also strongly inhibited tryptamine-induced hyperglucagonemia [7].

Biological context of xylamidine


Anatomical context of xylamidine


Associations of xylamidine with other chemical compounds


Gene context of xylamidine

  • In addition, the peripheral 5-HT2 receptor antagonist xylamidine strongly reduced 5-HT-induced hypothermia [18].
  • The food intake of 3-h-fasted male rats was studied after treatment with the COOH-terminal octapeptide of CCK (CCK-8) alone or in combination with one of two blockers of serotonin (5-HT) receptors, metergoline (MET; 1.0 or 0.06 mg/kg), active in both the periphery and brain, or xylamidine tosylate (XYL; 1.5 mg/kg), active only in the periphery [19].


  1. Effect of some serotoninergic agents on the rectal temperature of the domestic fowl (Gallus domesticus). Osuide, G., Wambebe, C., Bodhankar, S. Neuropharmacology (1984) [Pubmed]
  2. Vagal afferent-mediated inhibition of a nociceptive reflex by i.v. serotonin in the rat. II. Role of 5-HT receptor subtypes. Meller, S.T., Lewis, S.J., Brody, M.J., Gebhart, G.F. Brain Res. (1992) [Pubmed]
  3. Neurogenic dural protein extravasation induced by meta-chlorophenylpiperazine (mCPP) involves nitric oxide and 5-HT2B receptor activation. Johnson, K.W., Nelson, D.L., Dieckman, D.K., Wainscott, D.B., Lucaites, V.L., Audia, J.E., Owton, W.M., Phebus, L.A. Cephalalgia : an international journal of headache. (2003) [Pubmed]
  4. Central and peripheral injections of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, modify cardiovascular function through different mechanisms. Dedeoğlu, A., Fisher, L.A. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
  5. Evidence that the serotonin agonist, DOI, increases renin secretion and blood pressure through both central and peripheral 5-HT2 receptors. Rittenhouse, P.A., Bakkum, E.A., Van de Kar, L.D. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
  6. Serotonin 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction. Sipe, K., Leventhal, L., Burroughs, K., Cosmi, S., Johnston, G.H., Deecher, D.C. Brain Res. (2004) [Pubmed]
  7. Hyperglucagonemia induced in mice by tryptamine: involvement of the peripheral 5-HT2 receptors. Yamada, J., Sugimoto, Y., Kimura, I., Watanabe, Y., Takeuchi, N., Horisaka, K. Eur. J. Pharmacol. (1992) [Pubmed]
  8. Effects of dl-fenfluramine and xylamidine on gastric emptying of maintenance diet in freely feeding rats. Baker, B.J., Duggan, J.P., Barber, D.J., Booth, D.A. Eur. J. Pharmacol. (1988) [Pubmed]
  9. Cobaltous chloride-induced hypothermia in mice III: effect of pretreatment with 5-hydroxytryptaminergic agents. Burke, D.H., Brooks, J.C., Treml, S.B. Journal of pharmaceutical sciences. (1983) [Pubmed]
  10. Pharmacological evidence that circumventricular organs may participate in the pressor effect of central serotonin. Pérgola, P.E., Alper, R.H. Eur. J. Pharmacol. (1991) [Pubmed]
  11. Food intake and rumen motility in dwarf goats. Effects of some serotonin receptor agonists and antagonists. Kaya, F., Van Duin, C.T., Veenendaal, G.H., Van Miert, A.S. Vet. Res. Commun. (1992) [Pubmed]
  12. Role of central serotonergic (5-HT2) receptor in blood pressure regulation in rats. Kushiro, T., Kurumatani, H., Ishii, T., Yokoyama, H., Koike, J., Hatayama, Y., Kobayashi, Y., Kajiwara, N. Clinical and experimental hypertension. Part A, Theory and practice. (1988) [Pubmed]
  13. Selective 5-hydroxytryptamine2 antagonists have antidepressant-like effects on differential-reinforcement-of-low-rate 72-second schedule. Marek, G.J., Li, A.A., Seiden, L.S. J. Pharmacol. Exp. Ther. (1989) [Pubmed]
  14. Inhibition of human lymphocyte transformation by two aryloxyalkylamidines. Trist, D.G., Weatherall, M. J. Pharm. Pharmacol. (1982) [Pubmed]
  15. Evidence for central and peripheral serotonergic control of corticosterone secretion in the conscious rat. Alper, R.H. Neuroendocrinology (1990) [Pubmed]
  16. Role of 5-HT receptors in the effect of d-fenfluramine on gastric emptying and feeding behaviour as examined in the runway test. Samanin, R., Neill, J.C., Grignaschi, G., Padura, I.M., Bizzi, A., Garattini, S. Eur. J. Pharmacol. (1991) [Pubmed]
  17. Quipazine increases renin release by a peripheral hemodynamic mechanism. Zink, M.H., Pergola, P.E., Doane, J.F., Sved, A.F., Alper, R.H. J. Cardiovasc. Pharmacol. (1990) [Pubmed]
  18. Activation of peripheral serotonin2 receptors induces hypothermia in mice. Sugimoto, Y., Yamada, J., Horisaka, K. Life Sci. (1991) [Pubmed]
  19. Cholecystokinin-induced anorexia depends on serotoninergic function. Stallone, D., Nicolaïdis, S., Gibbs, J. Am. J. Physiol. (1989) [Pubmed]
WikiGenes - Universities