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Chemical Compound Review

tert-C4H9NO     2-methyl-2-nitroso-propane

Synonyms: NSC-150348, AC1L2LZY, CTK1C3765, NSC150348, ZINC04701625, ...
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High impact information on NSC 150348


Biological context of NSC 150348


Anatomical context of NSC 150348


Associations of NSC 150348 with other chemical compounds

  • EPR spin-trapping studies with the spin traps 3,5-dibromo-4-nitrosobenzenesulfonic acid and 2-methyl-2-nitrosopropane showed the intermediacy of methyl and a carbon-centered radical (*CH2COR) in the oxidation of EAA by peroxynitrite [9].
  • When an aqueous anaerobic solution (pH 5 or 9) of PSH (pKa = 7.7) and either 2-methyl-2-nitrosopropane (MNP) or nitromethane (NM) were irradiated (lambda > 300 nm) with a Xe arc lamp, the corresponding purine-6-thiyl (PS.) radical adduct and the reduced form of the spin trap (MNP/H. or CH3NO2.-) were observed [10].
  • The N2O-saturated aqueous solutions of purine nucleoside monophosphates, containing 2-methyl-2-nitrosopropane as a spin-trap, were X-irradiated and the resulting spin-adducts were separated by reverse-phase HPLC in the ion suppression mode [11].
  • When TCSA or TBSA were irradiated (lambda = 356 nm) in buffered (pH 7.4) 50% ethanol containing 2-methyl-2-nitrosopropane (MNP) only solvent-derived free radicals were detected [12].
  • Aqueous solutions of cyanide react with hydrogen peroxide/horseradish peroxidase and form the cyanyl radical, which can be trapped by 2-methyl-2-nitrosopropane (t-nitrosobutane, tNB) at pH 9 [13].

Gene context of NSC 150348


Analytical, diagnostic and therapeutic context of NSC 150348


  1. Reaction of human hemoglobin with peroxynitrite. Isomerization to nitrate and secondary formation of protein radicals. Romero, N., Radi, R., Linares, E., Augusto, O., Detweiler, C.D., Mason, R.P., Denicola, A. J. Biol. Chem. (2003) [Pubmed]
  2. Free-radical reactions induced by OH-radical attack on cytosine-related compounds: a study by a method combining ESR, spin trapping and HPLC. Hiraoka, W., Kuwabara, M., Sato, F., Matsuda, A., Ueda, T. Nucleic Acids Res. (1990) [Pubmed]
  3. Probing the free radicals formed in the metmyoglobin-hydrogen peroxide reaction. Gunther, M.R. Free Radic. Biol. Med. (2004) [Pubmed]
  4. Formation of methyl radicals during the catalase-mediated oxidation of formaldehyde hydrazone. Gomes, L.F., Augusto, O. Carcinogenesis (1991) [Pubmed]
  5. Spin-trapping studies on the free-radical products formed by metabolic activation of carbon tetrachloride in rat liver microsomal fractions isolated hepatocytes and in vivo in the rat. Albano, E., Lott, K.A., Slater, T.F., Stier, A., Symons, M.C., Tomasi, A. Biochem. J. (1982) [Pubmed]
  6. E.s.r. of spin-trapped radicals in gamma-irradiated polycrystalline DL-alanine. A quantitative determination of radical yield. Lion, Y., Denis, G., Mossoba, M.M., Riesz, P. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. (1983) [Pubmed]
  7. Prostaglandin hydroperoxidase-dependent oxidation of phenylbutazone: relationship to inhibition of prostaglandin cyclooxygenase. Hughes, M.F., Mason, R.P., Eling, T.E. Mol. Pharmacol. (1988) [Pubmed]
  8. Spin trapping of free radicals formed during peroxidation of sarcolemmal membranes (SLM). Arroyo, C.M., Mak, I.T., Weglicki, W.B. Free Radic. Res. Commun. (1989) [Pubmed]
  9. Peroxynitrite-initiated oxidation of acetoacetate and 2-methylacetoacetate esters by oxygen: potential sources of reactive intermediates in keto acidoses. Royer, L.O., Knudsen, F.S., de Oliveira, M.A., Tavares, M.F., Bechara, E.J. Chem. Res. Toxicol. (2004) [Pubmed]
  10. Photochemical sensitization by azathioprine and its metabolites. Part 3. A direct EPR and spin-trapping study of light-induced free radicals from 6-mercaptopurine and its oxidation products. Moore, D.E., Sik, R.H., Bilski, P., Chignell, C.F., Reszka, K.J. Photochem. Photobiol. (1994) [Pubmed]
  11. OH-induced free radicals in purine nucleoside monophosphates: e.s.r. and spin-trapping. Hiraoka, W., Kuwabara, M., Sato, F. Int. J. Radiat. Biol. (1989) [Pubmed]
  12. Spectroscopic studies of cutaneous photosensitizing agents--XIV. The spin trapping of free radicals formed during the photolysis of halogenated salicylanilide antibacterial agents. Chignell, C.F., Sik, R.H. Photochem. Photobiol. (1989) [Pubmed]
  13. Free radical intermediates formed during the oxidation of cyanide by horseradish peroxidase/H2O2 as detected with nitroso spin traps. Stolze, K., Moreno, S.N., Mason, R.P. J. Inorg. Biochem. (1989) [Pubmed]
  14. Phenylbutazone radicals inactivate creatine kinase. Miura, T., Muraoka, S., Fujimoto, Y. Free Radic. Res. (2001) [Pubmed]
  15. Photochemistry of 2-mercaptopyridines. Part 2. An EPR and spin-trapping investigation using 2-methyl-2-nitrosopropane and aci-nitromethane as spin traps in aqueous solutions. Reszka, K.J., Chignell, C.F. Photochem. Photobiol. (1994) [Pubmed]
  16. Electron paramagnetic resonance detection of free tyrosyl radical generated by myeloperoxidase, lactoperoxidase, and horseradish peroxidase. McCormick, M.L., Gaut, J.P., Lin, T.S., Britigan, B.E., Buettner, G.R., Heinecke, J.W. J. Biol. Chem. (1998) [Pubmed]
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