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Chemical Compound Review

Butesine     butyl 4-aminobenzoate

Synonyms: Butoform, butamben, Butesin, Planoform, Scuroform, ...
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Disease relevance of Scuroform


High impact information on Scuroform


Anatomical context of Scuroform

  • The antinociceptive and histologic effect of sciatic nerve blocks with 5% butamben suspension in rats [3].
  • Two cancer patients who had each received multiple injections of a 10% butamben suspension for the successful treatment of cancer pain prior to their deaths had autopsies and the spinal cords, meninges and spinal nerves were examined [9].

Associations of Scuroform with other chemical compounds


Analytical, diagnostic and therapeutic context of Scuroform

  • In this study, we investigated the effects of the local anesthetic n-butyl-p-aminobenzoate (BAB) on the delayed rectifier potassium current of cultured dorsal root ganglion (DRG) neurons using the patch-clamp technique [6].
  • Butamben, a lipophilic local anesthetic of the ester class, produces a differential nerve block of long duration [3].
  • We conclude that repeated epidural administration of butamben suspension for several days provides long-lasting analgesia in rats with nerve injury-induced allodynia to mechanical stimulation [11].
  • A HPLC method associated with butyl-p-aminobenzoate derivatization has been developed for the analysis of a tetraglucose oligomer, Glcalpha1-6Glcalpha1-4Glcalpha1-4Glc, designated Glc(4), in biological fluids [12].
  • The allodynia to mechanical stimulation induced by partial nerve ligation was significantly attenuated by daily injections, for 5 days, of 10 microL of butamben suspension [11].


  1. Inhibition of the A-type K+ channels of dorsal root ganglion neurons by the long-duration anesthetic butamben. Winkelman, D.L., Beck, C.L., Ypey, D.L., O'Leary, M.E. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  2. Long-lasting epidural sensory blockade by n-butyl-p-aminobenzoate in the terminally ill intractable cancer pain patient. Korsten, H.H., Ackerman, E.W., Grouls, R.J., van Zundert, A.A., Boon, W.F., Bal, F., Crommelin, M.A., Ribot, J.G., Hoefsloot, F., Slooff, J.L. Anesthesiology (1991) [Pubmed]
  3. The antinociceptive and histologic effect of sciatic nerve blocks with 5% butamben suspension in rats. McCarthy, R.J., Kerns, J.M., Nath, H.A., Shulman, M., Ivankovich, A.D. Anesth. Analg. (2002) [Pubmed]
  4. Allergic contact dermatitis from butyl aminobenzoate. van Ketel, W.G. Contact Derm. (1978) [Pubmed]
  5. Comparison of epidural butamben to celiac plexus neurolytic block for the treatment of the pain of pancreatic cancer. Shulman, M., Harris, J.E., Lubenow, T.R., Nath, H.A., Ivankovich, A.D. The Clinical journal of pain. (2000) [Pubmed]
  6. Kv1.1 channels of dorsal root ganglion neurons are inhibited by n-butyl-p-aminobenzoate, a promising anesthetic for the treatment of chronic pain. Beekwilder, J.P., O'Leary, M.E., van den Broek, L.P., van Kempen, G.T., Ypey, D.L., van den Berg, R.J. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  7. The local anesthetic n-butyl-p-aminobenzoate selectively affects inactivation of fast sodium currents in cultured rat sensory neurons. Van den Berg, R.J., Van Soest, P.F., Wang, Z., Grouls, R.J., Korsten, H.H. Anesthesiology (1995) [Pubmed]
  8. Orientations and locations of local anesthetics benzocaine and butamben in phospholipid membranes as studied by 2H NMR spectroscopy. Kuroda, Y., Nasu, H., Fujiwara, Y., Nakagawa, T. J. Membr. Biol. (2000) [Pubmed]
  9. Effect of epidural and subarachnoid injections of a 10% butamben suspension. Shulman, M., Joseph, N.J., Haller, C.A. Regional anesthesia. (1990) [Pubmed]
  10. Diffusion of n-butyl-p-aminobenzoate (BAB), lidocaine and bupivacaine through the human dura-arachnoid mater in vitro. Grouls, R., Korsten, E., Ackerman, E., Hellebrekers, L., van Zundert, A., Breimer, D. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. (2000) [Pubmed]
  11. The long-term effect of epidural administration of butamben suspension on nerve injury-induced allodynia in rats. Mitchell, V.A., White, D.M., Cousins, M.J. Anesth. Analg. (1999) [Pubmed]
  12. Liquid chromatographic assay for a glucose tetrasaccharide, a putative biomarker for the diagnosis of Pompe disease. An, Y., Young, S.P., Hillman, S.L., Van Hove, J.L., Chen, Y.T., Millington, D.S. Anal. Biochem. (2000) [Pubmed]
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