Disease relevance of fusidic acid

• Further experiments are needed to reassess the activity of fucidic acid against intracellular Brucella spp [1].
• Topical lomefloxacin twice daily compared with fucidic acid in acute bacterial conjunctivitis [2].
• The purpose of this study was to test the in vitro susceptibility of 50 Brucella melitensis isolates to fucidic acid, which has not previously been used for the treatment of brucellosis [1].
• The affected eye became amaurotic, but the panophthalmitis was controlled by minimal surgical debridement and systemic antibiotic therapy with penicillin, fucidic acid and metronidazole [3].
• PURPOSE: To compare the clinical and bacteriological effects of fucidic acid (Fucithalmic: 1.0%) and chloramphenicol (Minims(R): 0.5%) eye drops in neonates with a clinical diagnosis of acute conjunctivitis of suspected bacterial origin [4].

High impact information on fusidic acid

• The minimum inhibitory concentrations (MICs) of fucidic acid to 50 B. melitensis isolates that were obtained from blood and bone marrow cultures of patients with brucellosis were studied by the broth microdilution method [1].
• MRSA remained highly sensitive to vancomycin, clindamycin and fucidic acid [5].
• Treatment of acute neonatal bacterial conjunctivitis: a comparison of fucidic acid to chloramphenicol eye drops [4].

Associations of fusidic acid with other chemical compounds

• More than 90% of nosocomial MRSA strains were sensitive to Ofloxacin and Fucidic Acid. Resistance to Erythromycin, Lincomycin and Gentamicin was 70.1, 33.3 and 39.1% in that order [6].

Analytical, diagnostic and therapeutic context of fusidic acid

• All four treatment failures in the study occurred in the fucidic acid group [2].
• Forty-five patients with presumed acute bacterial conjunctivitis were treated in an investigator-masked randomized multicenter study with either lomefloxacin 0.3% or fucidic acid 1% eye drops twice daily [2].

References