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Chemical Compound Review

Butyl phthalate     dibutyl benzene-1,2-dicarboxylate

Synonyms: Elaol, Genoplast B, Palatinol C, Unimoll DB, Celluflex DPB, ...
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Disease relevance of Butyl phthalate


Psychiatry related information on Butyl phthalate

  • Among four different solvent mediators tested, dibutyl phthalate (DBP) exhibited a proper behavior including Nernstian slope of the calibration curve, fast response time and good reproducibility of the emf values [5].

High impact information on Butyl phthalate

  • In this follow-up report, we studied the neonates' exposure to DEHP-containing devices in relation to urinary concentrations of two other DEHP metabolites, and to urinary concentrations of metabolites of dibutyl phthalate (DBP) and benzylbutyl phthalate (BzBP) , phthalates found in construction materials and personal care products [6].
  • A method has been developed for the separation and determination of dimethyl phthalate (DMP), diethyl phthalate (DEP), di-n-butyl phthalate (DBP), di-(2-ethylhexyl) phthalate (DEHP) and di-n-octyl phthalate (DnOP) by micellar electrokinetic chromatography (MEKC) [7].
  • Dimethyl-phthalate (DMP), di-n-butyl-phthalate (DBP), and di-(2-ethylhexyl)-phthalate (DEHP) were detected in the river water at concentrations of 0.010-0.092, 0.008-0.540, and 0.013-3.60 microg L(-1), respectively [8].
  • Rats and hamsters treated with DBP demonstrated increased SOD activity at 6 days; however, in the rat, DBP decreased SOD activity at 90 days and alpha-tocopherol content was decreased throughout [9].
  • Bisphenol-A (BPA), dibutyl phthalate (DBP), and di-2-ethylhexyl phthalate (DEHP), which are common chemical residues in food-packaging materials, were investigated in paper and cardboard containers used for take-away food [10].

Biological context of Butyl phthalate

  • These findings indicate that the adversely altered adult phenotype following in utero exposure to linuron is very similar to that produced by the antiandrogens di-n-butyl phthalate (DBP) and di(2-ethylhexyl) phthalate (DEHP) [11].
  • Study on developmental abnormalities in hypospadiac male rats induced by maternal exposure to di-n-butyl phthalate (DBP) [12].

Anatomical context of Butyl phthalate

  • A new pharmacological activity of dibutyl phthalate (DBP) on selective elimination of tumor cells from bone marrow [13].
  • The Na and K contents of cultured endothelial cells, dissociated by scraping or trypsin and collagenase treatment and subsequently separated through oil (25% dodecyl-, 75% dibutyl-phthalate), were more than 20-fold higher and five-fold lower, respectively, than those of undissociated cells [14].
  • Second, we investigated the expression of CaBP-9k in the uterus of immature rats after oral treatment with BBP, DCHP, DEHP, DBP or DBP (600 mg/kg per day) in this in vivo model, because the immature rat model is highly sensitive to exposure to estrogenic chemicals [15].

Associations of Butyl phthalate with other chemical compounds

  • For most of the PAEs, internal standard quantification with deuterated dibutyl phthalate (DBP) and deuterated DEHP was best achieved by using electron ionization mass spectrometry in the selected-ion monitoring mode [16].

Gene context of Butyl phthalate

  • Both DEHP and DBP activated expression of PP-inducible gene products in wild-type but not PPARalpha-null mice suggesting that both of these phthalates exert their effects by activation of PPARalpha in vivo [17].
  • Di-n-butyl phthalate (DBP) was detected at a concentration of 7-60 ng/ml in most intravenous injection solutions in plastic containers, but it was not detected in solutions in glass bottles [18].
  • MEHP and DBP but not DEHP and MBP interacted directly with human PPARalpha and PPARgamma as determined by scintillation proximity assays [17].

Analytical, diagnostic and therapeutic context of Butyl phthalate

  • A novel "fiber-in-tube" configuration has been applied to the extraction tube of solid phase microextraction (SPME), and the direct coupling of the extraction process to liquid chromatography (LC) has been accomplished for the analysis of n-butylphthalate in wastewater [19].


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  2. Estimated exposure to phthaiates in cosmetics and risk assessment. Koo, H.J., Lee, B.M. J. Toxicol. Environ. Health Part A (2004) [Pubmed]
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  5. Preparation of a diclofenac potentiometric sensor and its application to pharmaceutical analysis and to drug recovery from biological fluids. Shamsipur, M., Jalali, F., Ershad, S. Journal of pharmaceutical and biomedical analysis. (2005) [Pubmed]
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  8. Monitoring of phthalic acid monoesters in river water by solid-phase extraction and GC-MS determination. Suzuki, T., Yaguchi, K., Suzuki, S., Suga, T. Environ. Sci. Technol. (2001) [Pubmed]
  9. Effects of peroxisome proliferators on antioxidant enzymes and antioxidant vitamins in rats and hamsters. O'Brien, M.L., Twaroski, T.P., Cunningham, M.L., Glauert, H.P., Spear, B.T. Toxicol. Sci. (2001) [Pubmed]
  10. Oestrogenicity of paper and cardboard extracts used as food containers. Lopez-Espinosa, M.J., Granada, A., Araque, P., Molina-Molina, J.M., Puertollano, M.C., Rivas, A., Fern??ndez, M., Cerrillo, I., Olea-Serrano, M.F., L??pez, C., Olea, N. Food additives and contaminants (2007) [Pubmed]
  11. Effects of in utero linuron exposure on rat Wolffian duct development. McIntyre, B.S., Barlow, N.J., Sar, M., Wallace, D.G., Foster, P.M. Reprod. Toxicol. (2002) [Pubmed]
  12. Study on developmental abnormalities in hypospadiac male rats induced by maternal exposure to di-n-butyl phthalate (DBP). Jiang, J., Ma, L., Yuan, L., Wang, X., Zhang, W. Toxicology (2007) [Pubmed]
  13. A new pharmacological activity of dibutyl phthalate (DBP) on selective elimination of tumor cells from bone marrow. Wu, C.T., Pei, X.T., Cao, J.R., Xue, H.H. Leuk. Res. (1993) [Pubmed]
  14. Changes in cation composition of aortic endothelial cells in culture. Adragna, N.C. Tissue & cell. (1988) [Pubmed]
  15. Conflict of estrogenic activity by various phthalates between in vitro and in vivo models related to the expression of Calbindin-D9k. Hong, E.J., Ji, Y.K., Choi, K.C., Manabe, N., Jeung, E.B. J. Reprod. Dev. (2005) [Pubmed]
  16. Determination of phthalates in crude extracts of sewage sludges by high-resolution capillary gas chromatography with mass spectrometric detection. Berset, J.D., Etter-Holzer, R. Journal of AOAC International. (2001) [Pubmed]
  17. Role of PPARalpha in mediating the effects of phthalates and metabolites in the liver. Lapinskas, P.J., Brown, S., Leesnitzer, L.M., Blanchard, S., Swanson, C., Cattley, R.C., Corton, J.C. Toxicology (2005) [Pubmed]
  18. Simple and rapid analysis of endocrine disruptors in liquid medicines and intravenous injection solutions by automated in-tube solid-phase microextraction/high performance liquid chromatography. Mitani, K., Narimatsu, S., Izushi, F., Kataoka, H. Journal of pharmaceutical and biomedical analysis. (2003) [Pubmed]
  19. Fiber-in-tube solid-phase microextraction: a fibrous rigid-rod heterocyclic polymer as the extraction medium. Saito, Y., Nakao, Y., Imaizumi, M., Takeichi, T., Kiso, Y., Jinno, K. Fresenius' journal of analytical chemistry. (2000) [Pubmed]
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