Disease relevance of Butyl phthalate

• In contrast, DBP and MBC directly altered testicular function, and for these compounds, sperm and testicular measures provided sensitive indicators of toxicity [1].
• Median exposure levels to phthalates in cosmetics by dermal absorption were estimated to be 0.0006 g/kg body weight (bw)/d for DEHP, 0.6 g/kg bw/d for DEP, and 0.103 g/kg bw/d for DBP [2].
• In combination with long-term liquid culture of marrow cells in vitro, DBP purged autologous bone marrow transplantation has first been applied to a case of acute myeloid leukemia at the first complete remission with successful reconstitution of hematopoiesis [3].
• Anaphylactic shock reaction to dibutyl-phthalate-containing capsules [4].

Psychiatry related information on Butyl phthalate

• Among four different solvent mediators tested, dibutyl phthalate (DBP) exhibited a proper behavior including Nernstian slope of the calibration curve, fast response time and good reproducibility of the emf values [5].

High impact information on Butyl phthalate

• In this follow-up report, we studied the neonates' exposure to DEHP-containing devices in relation to urinary concentrations of two other DEHP metabolites, and to urinary concentrations of metabolites of dibutyl phthalate (DBP) and benzylbutyl phthalate (BzBP) , phthalates found in construction materials and personal care products [6].
• A method has been developed for the separation and determination of dimethyl phthalate (DMP), diethyl phthalate (DEP), di-n-butyl phthalate (DBP), di-(2-ethylhexyl) phthalate (DEHP) and di-n-octyl phthalate (DnOP) by micellar electrokinetic chromatography (MEKC) [7].
• Dimethyl-phthalate (DMP), di-n-butyl-phthalate (DBP), and di-(2-ethylhexyl)-phthalate (DEHP) were detected in the river water at concentrations of 0.010-0.092, 0.008-0.540, and 0.013-3.60 microg L(-1), respectively [8].
• Rats and hamsters treated with DBP demonstrated increased SOD activity at 6 days; however, in the rat, DBP decreased SOD activity at 90 days and alpha-tocopherol content was decreased throughout [9].
• Bisphenol-A (BPA), dibutyl phthalate (DBP), and di-2-ethylhexyl phthalate (DEHP), which are common chemical residues in food-packaging materials, were investigated in paper and cardboard containers used for take-away food [10].

Biological context of Butyl phthalate

• These findings indicate that the adversely altered adult phenotype following in utero exposure to linuron is very similar to that produced by the antiandrogens di-n-butyl phthalate (DBP) and di(2-ethylhexyl) phthalate (DEHP) [11].
• Study on developmental abnormalities in hypospadiac male rats induced by maternal exposure to di-n-butyl phthalate (DBP) [12].

Anatomical context of Butyl phthalate

• A new pharmacological activity of dibutyl phthalate (DBP) on selective elimination of tumor cells from bone marrow [13].
• The Na and K contents of cultured endothelial cells, dissociated by scraping or trypsin and collagenase treatment and subsequently separated through oil (25% dodecyl-, 75% dibutyl-phthalate), were more than 20-fold higher and five-fold lower, respectively, than those of undissociated cells [14].
• Second, we investigated the expression of CaBP-9k in the uterus of immature rats after oral treatment with BBP, DCHP, DEHP, DBP or DBP (600 mg/kg per day) in this in vivo model, because the immature rat model is highly sensitive to exposure to estrogenic chemicals [15].

Associations of Butyl phthalate with other chemical compounds

• For most of the PAEs, internal standard quantification with deuterated dibutyl phthalate (DBP) and deuterated DEHP was best achieved by using electron ionization mass spectrometry in the selected-ion monitoring mode [16].

Gene context of Butyl phthalate

• Both DEHP and DBP activated expression of PP-inducible gene products in wild-type but not PPARalpha-null mice suggesting that both of these phthalates exert their effects by activation of PPARalpha in vivo [17].
• Di-n-butyl phthalate (DBP) was detected at a concentration of 7-60 ng/ml in most intravenous injection solutions in plastic containers, but it was not detected in solutions in glass bottles [18].
• MEHP and DBP but not DEHP and MBP interacted directly with human PPARalpha and PPARgamma as determined by scintillation proximity assays [17].

Analytical, diagnostic and therapeutic context of Butyl phthalate

• A novel "fiber-in-tube" configuration has been applied to the extraction tube of solid phase microextraction (SPME), and the direct coupling of the extraction process to liquid chromatography (LC) has been accomplished for the analysis of n-butylphthalate in wastewater [19].

References