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Chemical Compound Review

Bitolterol     [5-[1-hydroxy-2-(tert- butylamino)ethyl]-2...

Synonyms: Bitolterolum, SureCN28133, CHEBI:3133, CHEMBL1201295, AC1L1THX, ...
 
 
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Disease relevance of Bitolterol

 

High impact information on Bitolterol

 

Biological context of Bitolterol

  • In the cardiovascular studies in anesthetized dogs, chronotropic, inotropic and blood pressure effects of bitolterol were markedly reduced relative to its bronchodilator effect [6].
  • The sc LD50 values for isoproterenol in 4- to 5-month-old, 500-600 g (heavy) and 1.5- to 2-month-old, 150-200 g (small) male Sprague-Dawley rats were 0.6 mg/kg and 1300 mg/kg, respectively, and values for bitolterol were 4 mg/kg and greater than 1800 mg/kg, respectively [7].
 

Anatomical context of Bitolterol

 

Associations of Bitolterol with other chemical compounds

 

Gene context of Bitolterol

 

Analytical, diagnostic and therapeutic context of Bitolterol

References

  1. Bitolterol compared to isoproterenol in advanced chronic obstructive pulmonary disease. Petty, T.L., Scoggin, C.H., Rollins, D.R., Repsher, L.H. Chest (1984) [Pubmed]
  2. Retrospective study of bitolterol mesylate in the treatment of conditions associated with reversible bronchospasm. Messina, M.S. Advances in therapy. (1995) [Pubmed]
  3. Multicenter study of bitolterol and isoproterenol nebulizer solutions in nonsteroid-using patients. Pinnas, J.L., Bernstein, I.L., Bronsky, E.E., Bush, R.K., Chervinsky, P., Condemi, J.J., Dockhorn, R.J., Nathan, R.A., Repsher, L.H., Bhatt, B.D. J. Allergy Clin. Immunol. (1987) [Pubmed]
  4. Bitolterol and albuterol metered-dose aerosols: comparison of two long-acting beta 2-adrenergic bronchodilators for treatment of asthma. Orgel, H.A., Kemp, J.P., Tinkelman, D.G., Webb, D.R. J. Allergy Clin. Immunol. (1985) [Pubmed]
  5. Bitolterol. A preliminary review of its pharmacological properties and therapeutic efficacy in reversible obstructive airways disease. Friedel, H.A., Brogden, R.N. Drugs (1988) [Pubmed]
  6. Studies on bitolterol, di-p-toluate ester of N-tert.-butylarterenol: a new long-acting bronchodilator with reduced cardiovascular effects. Minatoya, H. J. Pharmacol. Exp. Ther. (1978) [Pubmed]
  7. Enhancement of cardiotoxic effects of beta-adrenergic bronchodilators by aminophylline in experimental animals. Joseph, X., Whitehurst, V.E., Bloom, S., Balazs, T. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1981) [Pubmed]
  8. Physiological disposition and metabolism of (3H)bitolterol in man and dog. Shargel, L., Dorrbecker, S.A. Drug Metab. Dispos. (1976) [Pubmed]
  9. Physiological disposition and metabolism of N-t-butylarterenol and its di-p-toluate ester (bitolterol) in the rat. Shargel, L., Dorrbecker, S.A., Levitt, M. Drug Metab. Dispos. (1976) [Pubmed]
  10. The influences of the route of administration on the metabolism and excretion of bitolterol, a new bronchodilator, in the rat. Aimoto, T., Ito, O., Kimura, R., Murata, T., Ito, K. Xenobiotica (1979) [Pubmed]
  11. Salmeterol: an inhaled beta 2-agonist with prolonged duration of action. Lötvall, J., Svedmyr, N. Lung (1993) [Pubmed]
  12. Dose-response study of nebulized bitolterol mesylate solution in asthmatic patients. Pinnas, J.L., Bhatt, B.D., Campbell, S.C., Kemp, J.P., Tinkelman, D.G. Chest (1987) [Pubmed]
  13. Microencapsulation of bitolterol for controlled release and its effect on bronchodilator and heart rate activities in dogs. John, P.M., Minatoya, H., Rosenberg, F.J. Journal of pharmaceutical sciences. (1979) [Pubmed]
  14. Nocturnal asthma therapy. Inhaled bitolterol versus sustained-release theophylline. Zwillich, C.W., Neagley, S.R., Cicutto, L., White, D.P., Martin, R.J. Am. Rev. Respir. Dis. (1989) [Pubmed]
  15. Outpatient management of asthma with regular nebulized beta agonists: comparison of bitolterol mesylate and isoproterenol. Kemp, J.P., Orgel, H.A., Grossman, J., Reed, C.E., Tinkelman, D.G., Webb, D.R., Ziment, I. Annals of allergy. (1987) [Pubmed]
 
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