Disease relevance of Drug Compounding

• In a murine chloroma model, delivery of VEGF(165) using microencapsulation technology resulted in enhanced tumor growth and vascularization, whereas treatment with a VEGF antagonist soluble NRP-1 (sNRP-1) inhibited tumor angiogenesis and growth [1].
• PURPOSE: As part of pharmacologic studies of asparaginase (ASNase), we determined the half-life of ASNase activity and protein, and the effect of dose, repeated doses, different drug preparations, and hypersensitivity reactions on the half-life (t1/2) of serum ASNase activity [2].
• 4-chloro-m-cresol triggers malignant hyperthermia in susceptible swine at doses greatly exceeding those found in drug preparations [3].
• Effect of microencapsulation on immunogenicity of a bovine herpes virus glycoprotein and inactivated influenza virus in mice [4].
• A microencapsulation delivery system for Bifidobacterium lactis, a possible probiotic suited for use by the rural population of South Africa, was evaluated using two existing traditional fermented foods, amasi and mahewu [5].

High impact information on Drug Compounding

• A new process allows microencapsulation of purified human hemoglobin and 2,3-diphosphoglycerate to form neohemocytes [6].
• Engineered Chinese hamster ovary cells (CHO-K1) showed toggle switch-specific expression profiles of a human glycoprotein in culture, as well as after microencapsulation and implantation into mice [7].
• We investigated the effect of alginate-polylysine-alginate microencapsulation on glucose-induced insulin secretion by rat islets [8].
• DESIGN: Blinded crossover trial with controls for the protein and diluent components of the drug preparation [9].
• BACKGROUND: Benzoic acid is one of the most commonly used preservatives in cosmetics, foodstuffs, and drug preparations [10].

Chemical compound and disease context of Drug Compounding

• 4-CmC is a preservative within a large number of commercially available drug-preparations (e.g., insulin, heparin, succinylcholine), and it has been suggested that 4-CmC might trigger malignant hyperthermia [11].
• Microencapsulation of Aerococcus viridans with catalase and its application for the synthesis of dihydroxyacetone phosphate [12].
• CONCLUSIONS: Programs to limit parenteral transmission of HIV and other blood-borne infections among IDUs must consider all drug preparation and injection practices that could allow transfer of blood and blood-borne infections among IDUs [13].
• With microencapsulation of Lactobacillus (inside semipermeable alginate-polylysine-alginate polymeric membrane), further lowering of urea nitrogen levels was achieved (35.4 +/- 0.8 mg/dL, P = 0.03) at 24 hours [14].
• Application of microencapsulation for toxicology studies. II. Toxicity of microencapsulated trichloroethylene in Fischer 344 rats [15].

Biological context of Drug Compounding

• This was realized by transfection of the CYP2B1 gene, the major ifosfamide-converting P450 enzyme, in cells with subsequent microencapsulation and administration of these microcapsules to or into the tumor [16].
• The results provide a rational basis for the further development of theophylline formulations and are indispensable for planned development and to account for variation in the bioavailability of retarded release drug preparations [17].
• As expected, each drug preparation was more effective in reducing intraocular pressure when administered to a patient who had already been treated with the carbonic anhydrase inhibitor preparation [18].
• The aim of this study was to assess cell viability and the function of rat pinealocytes encapsulated in APA capsules and offer experimental suggestions for pineal microencapsulation grafting to resist aging [19].
• Application of microencapsulation for toxicology studies. I. Principles and stabilization of trichloroethylene in gelatin-sorbitol microcapsules [20].

Anatomical context of Drug Compounding

• CONCLUSIONS: Pancreatic islets isolated from human, rat, and mouse donors show a glucose-stimulated insulin release in vitro after microencapsulation and repeated transports between laboratories [21].
• Microencapsulation of Leydig cells: a system for testosterone supplementation [22].
• Microencapsulation of CHO cells in a hydroxyethyl methacrylate-methyl methacrylate copolymer [23].
• In order to assess the viability of this proposal, dopamine-secreting PC12 cells were immunoisolated via microencapsulation in a 75:25 2-hydroxyethyl methacrylate/methyl methacrylate (HEMA/MMA) copolymer [24].
• 1. The ability of dextran sulphate to protect cultured porcine arterial endothelial cells injured by addition of xanthine and xanthine oxidase (X/XO) or hydrogen peroxide to cell medium was examined using a variety of drug preparations [25].

Associations of Drug Compounding with chemical compounds

• Nitrofurantoin showed little anti-P. carinii activity despite different doses or drug preparations [26].
• In this study, we examined the glycemia and insulin secretion in streptozotocin-diabetic rats transplanted with islets subjected to immunoisolation with Algire diffusion chamber or with microencapsulation [27].
• CONCLUSIONS: Microencapsulation using the present alginate/poly-L-lysine/alginate capsules does not protect islets against the detrimental effects of IL-1beta and TNF-alpha [28].
• The method was applicable to the qualitative and quantitative analysis of prostaglandin E1 in a drug preparation [29].
• The immunogenicity of formalin-treated influenza vaccine was preserved during the microencapsulation process, and the microencapsulated antigen induced protective immune responses after systemic immunization that were equal to or higher than those induced by conventional vaccine [30].

Gene context of Drug Compounding

• The microencapsulation of parathyroid tissue fragments or of parathyroid cells becomes, therefore, a potential approach for the successful treatment of permanent symptomatic hypoparathyroidism without pharmacological immunosuppression [31].
• Although the extent of lipid peroxidation in plasma of RA patients could be decreased by both drug preparations, the reduction mediated in 3 months by MRQ (34%) was markedly greater than that due to WC (21.8%) [32].
• The purpose of this work is to evaluate the possibility of enzyme replacement therapy through prolidase microencapsulation in biodegradable microspheres [33].
• Different polymer compositions were studied for the microencapsulation of EPO using a modified double-emulsion process (W/O/W) [34].
• Towards the preparation of a MMA-PEO block copolymer for the microencapsulation of mammalian cells [35].

Analytical, diagnostic and therapeutic context of Drug Compounding

• Interestingly, the immunogenicity was less influenced by the type of antigen-stabilising excipient, the number of microsphere populations mixed together, or the microencapsulation technology, i.e. spray-drying versus coacervation, used [36].
• The effect of microencapsulation on islet allograft survivals was determined using a streptozotocin-induced diabetic (STZ) mouse and a nonobese diabetic (NOD) mouse as recipients [37].
• A method for the quantitative determination of the opium alkaloids morphine, codeine, thebaine, noscapine and papaverine in crude opium and in drug preparations based on non-aqueous capillary electrophoresis has been developed [38].
• After each drug preparation was optimized, patients were rated by neurological examination and plasma levodopa (LD) measured at hourly intervals (9 a.m.-4 p.m.). For the group as a whole, variations throughout the day of plasma LD and clinical state were no different on the 2 formulations [39].
• Marked prolongation of islet xenograft survival (hamster to mouse) by microencapsulation and administration of 15-deoxyspergualin [40].

References