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MeSH Review

Metered Dose Inhalers

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Disease relevance of Metered Dose Inhalers


High impact information on Metered Dose Inhalers


Chemical compound and disease context of Metered Dose Inhalers


Biological context of Metered Dose Inhalers


Anatomical context of Metered Dose Inhalers


Associations of Metered Dose Inhalers with chemical compounds


Gene context of Metered Dose Inhalers

  • METHODS: Patients with COPD were enrolled in two 6-month randomised, placebo controlled, double blind, double dummy studies of tiotropium 18 micro g once daily via HandiHaler or salmeterol 50 micro g twice daily via a metered dose inhaler [29].
  • BACKGROUND: The Medtrac MDI Chronolog is an electronic device for monitoring adherence to metered-dose inhalers [30].
  • OBJECTIVE: We sought to evaluate step-down therapy with a fluticasone propionate-salmeterol (FP-SM) combination administered through a dry powder inhaler (DPI; Advair Diskus) versus a medium dose of hydrofluoroalkane 143a-beclomethasone dipropionate (HFA-BDP) administered through a breath-actuated pressurized metered-dose inhaler (QVAR Autohaler) [31].
  • After the LAR occurred, a placebo and fenoterol were administered blindly by a metered-dose inhaler, with an interval of 15 minutes and in alternating, random sequence [32].
  • IB/FEN has been available for the treatment of asthma and COPD in a pressurised metered dose inhaler (MDI) [pMDI] formulation for many years [33].

Analytical, diagnostic and therapeutic context of Metered Dose Inhalers


  1. A comparison of inhaled fluticasone and oral prednisone for children with severe acute asthma. Schuh, S., Reisman, J., Alshehri, M., Dupuis, A., Corey, M., Arseneault, R., Alothman, G., Tennis, O., Canny, G. N. Engl. J. Med. (2000) [Pubmed]
  2. For COPD a combination of ipratropium bromide and albuterol sulfate is more effective than albuterol base. Campbell, S. Arch. Intern. Med. (1999) [Pubmed]
  3. Cromolyn versus nedocromil: duration of action in exercise-induced asthma in children. de Benedictis, F.M., Tuteri, G., Pazzelli, P., Bertotto, A., Bruni, L., Vaccaro, R. J. Allergy Clin. Immunol. (1995) [Pubmed]
  4. Oropharyngeal candidiasis in patients treated with beclomethasone dipropionate delivered by metered-dose inhaler alone and with Aerochamber. Salzman, G.A., Pyszczynski, D.R. J. Allergy Clin. Immunol. (1988) [Pubmed]
  5. Nebulised salbutamol administered during sputum induction improves bronchoprotection in patients with asthma. Delvaux, M., Henket, M., Lau, L., Kange, P., Bartsch, P., Djukanovic, R., Louis, R. Thorax (2004) [Pubmed]
  6. Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study. Anthonisen, N.R., Connett, J.E., Kiley, J.P., Altose, M.D., Bailey, W.C., Buist, A.S., Conway, W.A., Enright, P.L., Kanner, R.E., O'Hara, P. JAMA (1994) [Pubmed]
  7. Cromolyn therapy in patients with bronchial asthma. Effect on inhalation challenge with allergen, histamine, and methacholine. Ryo, U.Y., Kang, B., Townley, R.G. JAMA (1976) [Pubmed]
  8. Multicentre randomised placebo-controlled trial of inhaled fluticasone propionate in patients with chronic obstructive pulmonary disease. International COPD Study Group. Paggiaro, P.L., Dahle, R., Bakran, I., Frith, L., Hollingworth, K., Efthimiou, J. Lancet (1998) [Pubmed]
  9. Pentamidine prophylaxis with a metered-dose inhaler. Miller, R.F., Buckland, J.A., Pang, M., Qiu, J., Taylor, K.M. Lancet (1991) [Pubmed]
  10. Bronchodilator, cardiovascular, and hypokalaemic effects of fenoterol, salbutamol, and terbutaline in asthma. Wong, C.S., Pavord, I.D., Williams, J., Britton, J.R., Tattersfield, A.E. Lancet (1990) [Pubmed]
  11. Direct labelling of ipratropium bromide aerosol and its deposition pattern in normal subjects and patients with chronic bronchitis. Spiro, S.G., Singh, C.A., Tolfree, S.E., Partridge, M.R., Short, M.D. Thorax (1984) [Pubmed]
  12. The effect of 10, 50 and 200 micrograms inhaled fenoterol on exercise induced asthma. Rabe, K.F., Jörres, R., Magnussen, H. Clin. Exp. Allergy (1993) [Pubmed]
  13. Comparison of outpatient nebulized vs metered dose inhaler terbutaline in chronic airflow obstruction. Mestitz, H., Copland, J.M., McDonald, C.F. Chest (1989) [Pubmed]
  14. Montelukast attenuates the airway response to hypertonic saline in moderate-to-severe COPD. Zühlke, I.E., Kanniess, F., Richter, K., Nielsen-Gode, D., Böhme, S., Jörres, R.A., Magnussen, H. Eur. Respir. J. (2003) [Pubmed]
  15. The separation of ipratropium bromide and its related compounds. Simms, P.J., Towne, R.W., Gross, C.S., Miller, R.E. Journal of pharmaceutical and biomedical analysis. (1998) [Pubmed]
  16. Use of bronchial provocation with histamine to compare the pharmacodynamics of inhaled albuterol and metaproterenol in patients with asthma. Ahrens, R.C., Harris, J.B., Milavetz, G., Annis, L., Ries, R. J. Allergy Clin. Immunol. (1987) [Pubmed]
  17. Protection against methacholine bronchoconstriction to assess relative potency of inhaled beta2-agonist. Parameswaran, K.N., Inman, M.D., Ekholm, B.P., Morris, M.M., Summers, E., O'Byrne, P.M., Hargreave, F.E. Am. J. Respir. Crit. Care Med. (1999) [Pubmed]
  18. Lung bioavailability of generic and innovator salbutamol metered dose inhalers. Clark, D.J., Gordon-Smith, J., McPhate, G., Clark, G., Lipworth, B.J. Thorax (1996) [Pubmed]
  19. Comparison of terbutaline and placebo from a pressurised metered dose inhaler and a dry powder inhaler in a subgroup of patients with asthma. Selroos, O., Löfroos, A.B., Pietinalho, A., Riska, H. Thorax (1994) [Pubmed]
  20. Time course and relative dose potency of systemic effects from salmeterol and salbutamol in healthy subjects. Bennett, J.A., Tattersfield, A.E. Thorax (1997) [Pubmed]
  21. The contribution of the swallowed fraction of an inhaled dose of salmeterol to it systemic effects. Bennett, J.A., Harrison, T.W., Tattersfield, A.E. Eur. Respir. J. (1999) [Pubmed]
  22. Otitis media: treatment with intranasal aerosolized surfactant. Chandrasekhar, S.S., Mautone, A.J. Laryngoscope (2004) [Pubmed]
  23. Improved delivery of inhaled steroids to the large and small airways. Leach, C.L. Respiratory medicine. (1998) [Pubmed]
  24. Ipratropium bromide HFA. Wellington, K. Treatments in respiratory medicine. (2005) [Pubmed]
  25. Non-pulmonary effects induced by the addition of formoterol to budesonide therapy in patients with mild or moderate persistent asthma. Centanni, S., Carlucci, P., Santus, P., Boveri, B., Tarricone, D., Fiorentini, C., Lombardi, F., Cazzola, M. Respiration; international review of thoracic diseases. (2000) [Pubmed]
  26. Fenoterol by metered dose inhaler and delay of steroid therapy. Kasuya, S., Kawachi, H. Lancet (1989) [Pubmed]
  27. Aerosol beclomethasone in patients with steroid-responsive chronic obstructive pulmonary disease. Shim, C.S., Williams, M.H. Am. J. Med. (1985) [Pubmed]
  28. Hemodynamic effects of an inhaled beta-2 agonist. Chapman, K.R., Smith, D.L., Rebuck, A.S., Leenen, F.H. Clin. Pharmacol. Ther. (1984) [Pubmed]
  29. Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD. Brusasco, V., Hodder, R., Miravitlles, M., Korducki, L., Towse, L., Kesten, S. Thorax (2003) [Pubmed]
  30. Reliability of the Medtrac MDI Chronolog. Brueckner, J.W., Marshik, P., Sherman, J., Hendeles, L. J. Allergy Clin. Immunol. (1997) [Pubmed]
  31. Step-down therapy with low-dose fluticasone-salmeterol combination or medium-dose hydrofluoroalkane 134a-beclomethasone alone. Fowler, S.J., Currie, G.P., Lipworth, B.J. J. Allergy Clin. Immunol. (2002) [Pubmed]
  32. The effect of inhaled fenoterol, administered during the late asthmatic reaction to house dust mite (Dermatophagoides pteronyssinus). Van Bever, H.P., Desager, K.N., Stevens, W.J. J. Allergy Clin. Immunol. (1990) [Pubmed]
  33. A review of ipratropium bromide/fenoterol hydrobromide (Berodual) delivered via Respimat Soft Mist Inhaler in patients with asthma and chronic obstructive pulmonary disease. Kässner, F., Hodder, R., Bateman, E.D. Drugs (2004) [Pubmed]
  34. Comparison of bronchodilator responses with bitolterol mesylate solution with the use of two different nebulizer systems in asthma. Kemp, J.P., Pinnas, J.L., Tinkelman, D.G., Meltzer, E.O., Campbell, S.C., Orgel, H.A., Welch, M.J., Mingo, T.S. J. Allergy Clin. Immunol. (1986) [Pubmed]
  35. Effect of acute and chronic inhaled furosemide on bronchial hyperresponsiveness in mild asthma. Yates, D.H., O'Connor, B.J., Yilmaz, G., Aikman, S., Worsdell, M., Barnes, P.J., Chung, K.F. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  36. Exhaled nitric oxide after beta2-agonist inhalation and spirometry in asthma. Silkoff, P.E., Wakita, S., Chatkin, J., Ansarin, K., Gutierrez, C., Caramori, M., McClean, P., Slutsky, A.S., Zamel, N., Chapman, K.R. Am. J. Respir. Crit. Care Med. (1999) [Pubmed]
  37. Review of therapeutically equivalent alternatives to short acting beta(2) adrenoceptor agonists delivered via chlorofluorocarbon-containing inhalers. Hughes, D.A., Woodcock, A., Walley, T. Thorax (1999) [Pubmed]
  38. Case-control study of prescribed fenoterol and death from asthma in New Zealand, 1977-81. Pearce, N., Grainger, J., Atkinson, M., Crane, J., Burgess, C., Culling, C., Windom, H., Beasley, R. Thorax (1990) [Pubmed]
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