Disease relevance of Travogen

• Pustular allergic contact dermatitis to isoconazole nitrate [1].

High impact information on Travogen

• The release of isoconazole nitrate from different suppository bases: in-vitro dissolution, physicochemical and microbiological studies [2].
• Ketoconazole, miconazole, isoconazole, and econazole interacted with the cell wall causing formation of convolutions and wrinkles [3].
• A total of 40 coal miners, 35 with culturally proven mycotic infections of the feet and 5 with similarly proven infections of toenails due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes, were treated with 1% cream of either isoconazole nitrate (Travogen) or clotrimazole (Canestan) for 4 weeks [4].
• Butoconazole and isoconazole were also very active against isolates of C. albicans, and were the most active azole compounds against 80 isolates of Candida spp [5].
• Glycosidic activities of Candida albicans after action of vegetable latex saps (natural antifungals) and isoconazole (synthetic antifungal) [6].

Anatomical context of Travogen

• Comparative studies with chemically related compounds showed similar effects on testosterone production of mouse Leydig cells by isoconazole, miconazole, econazole and clotrimazole, while metronidazole and levamisole were without influence on testosterone biosynthesis [7].

Associations of Travogen with other chemical compounds

• One week after treatment 100% of the clotrimazole treated patients and 98% of the isoconazole treated group gave mycologically negative results [8].
• Randomized comparative study on the treatment of vaginal mycosis by single dose of isoconazole and multiple dose of nystatin [9].

Analytical, diagnostic and therapeutic context of Travogen

• In a single blind trial there was no significant difference between econazole (2 X 150 mg pessaries) and isoconazole (2 X 300 mg pessaries) given as a once only treatment for vaginal candidosis [10].

References