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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

L Forms

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Disease relevance of L Forms


High impact information on L Forms

  • The transcriptional activities of the J and L forms of PTF1 are independent of Notch signaling, because P48 occupies the NotchIC docking site on RBP-J and RBP-L does not bind the NotchIC [6].
  • There was no marked difference in antiaggregatory potency between the d- and l-forms of diltiazem and N-demethyl diltiazem [7].
  • Pentoses, such as arabinose, ribose, and deoxyribose, inhibit the interaction between SP-D and mannan, one of the well-studied hexose ligands for SP-D, and biologically relevant d-forms of the pentoses are better competitors than the l-forms [8].
  • Both enzymes were found to be inhibited by S-adenosylhomocysteine (D and L forms), S-adenosyl-L-ethionine, and sinefungin [9].
  • Treatment with alkaline phosphatase converted the phenylalanine hydroxylase H forms to the L forms [10].

Chemical compound and disease context of L Forms


Biological context of L Forms


Anatomical context of L Forms


Gene context of L Forms

  • Western blot analysis showed that both H and L forms reacted with anti MBP antibodies [21].
  • Here, we show by co-precipitation of differently tagged Nha1p proteins expressed in the same cell that the yeast Nha1p l forms an oligomer [22].
  • Both the H and L forms of SV2 are present in these vesicles and all are keratan sulfate proteoglycans [23].
  • Transcription of type II collagen, prolyl 4-hydroxylase (alpha subunit), and aggrecan increased in response to the antiscorbutic forms of ascorbic acid (L-Asc, Na L-Asc, and A2P) and was stereospecific to the L-forms [24].
  • Moreover, the percentage of CD3+, CD4+, CD8+, the ratio of CD4+/CD8+, and the levels of IL-2, IL-6 and IL-8 in patients infected with both H pylori L-forms and vegetative forms were 46.67+/-5.21%, 30.75+/-4.89%, 22.15+/-6.45%, 1.32+/-0.47%, 1.16+/-0.38 mg/L, 116.45+/-5.44 ng/L, and 118.64+/-6.24 ng/L, respectively [25].


  1. Tetracycline-resistant L-forms isolated from an antibiotic-susceptible strain of Listeria monocytogenes. Schmitt-Slomska, J., Marmouset, M.C., Louis, C., Bally, R., Starka, G., Madoff, S. Antimicrob. Agents Chemother. (1982) [Pubmed]
  2. Variations in properties of L-forms of Pseudomonas aeruginosa. Bertolani, R., Elberg, S.S., Ralston, D. Infect. Immun. (1975) [Pubmed]
  3. Factors affecting antimicrobial susceptibility of Fusobacterium species. Rowland, M.D., Del Bene, V.E., Lewis, J.W. J. Clin. Microbiol. (1987) [Pubmed]
  4. Effect of nalidixic acid on the conversion of Staphylococcus aureus cells to L-forms in a liquid medium with 6-aminopenicillanic acid and lysozyme. Yabu, K. Microbiol. Immunol. (1986) [Pubmed]
  5. Induction of L-forms of Haemophilus influenzae in vitro. Want, S.V., May, J.R. J. Med. Microbiol. (1975) [Pubmed]
  6. PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L. Beres, T.M., Masui, T., Swift, G.H., Shi, L., Henke, R.M., MacDonald, R.J. Mol. Cell. Biol. (2006) [Pubmed]
  7. Inhibition of platelet aggregation by diltiazem. Comparison with verapamil and nifedipine and inhibitory potencies of diltiazem metabolites. Kiyomoto, A., Sasaki, Y., Odawara, A., Morita, T. Circ. Res. (1983) [Pubmed]
  8. Nucleic acid is a novel ligand for innate, immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin. Palaniyar, N., Nadesalingam, J., Clark, H., Shih, M.J., Dodds, A.W., Reid, K.B. J. Biol. Chem. (2004) [Pubmed]
  9. Two histone H1-specific protein-lysine N-methyltransferases from Euglena gracilis. Purification and characterization. Tuck, M.T., Farooqui, J.Z., Paik, W.K. J. Biol. Chem. (1985) [Pubmed]
  10. Two apparent molecular weight forms of human and monkey phenylalanine hydroxylase are due to phosphorylation. Smith, S.C., Kemp, B.E., McAdam, W.J., Mercer, J.F., Cotton, R.G. J. Biol. Chem. (1984) [Pubmed]
  11. Cooperative binding interactions of glycopeptide antibiotics. Shiozawa, H., Chia, B.C., Davies, N.L., Zerella, R., Williams, D.H. J. Am. Chem. Soc. (2002) [Pubmed]
  12. Investigating beta-hydroxyenduracididine formation in the biosynthesis of the mannopeptimycins. Haltli, B., Tan, Y., Magarvey, N.A., Wagenaar, M., Yin, X., Greenstein, M., Hucul, J.A., Zabriskie, T.M. Chem. Biol. (2005) [Pubmed]
  13. Identification of a mitochondrial transporter for basic amino acids in Arabidopsis thaliana by functional reconstitution into liposomes and complementation in yeast. Hoyos, M.E., Palmieri, L., Wertin, T., Arrigoni, R., Polacco, J.C., Palmieri, F. Plant J. (2003) [Pubmed]
  14. Separation of alpha-hydroxy acid enantiomers by high performance capillary electrophoresis using copper(II)-L-amino acid and copper(II)-aspartame complexes as chiral selectors in the background electrolyte. Desiderio, C., Aturki, Z., Fanali, S. Electrophoresis (1994) [Pubmed]
  15. Cytochrome c specific methylase from wheat germ. DiMaria, P., Kim, S., Paik, W.K. Biochemistry (1982) [Pubmed]
  16. Further evidence of polyethylene glycol-induced cell fusion of Staphylococcus aureua L-forms. Hirachi, Y., Kurono, M., Kotani, S. Biken journal. (1980) [Pubmed]
  17. Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Davies, J., Watkins, J.C. Brain Res. (1982) [Pubmed]
  18. Lipid composition of Staphylococcus aureus and its derived L-forms. Hayami, M., Okabe, A., Kariyama, R., Abe, M., Kanemasa, Y. Microbiol. Immunol. (1979) [Pubmed]
  19. Production of L-forms of Streptococcus pyogenes and their antitumor effects. Yamamoto, A., Homma, J.Y., Usami, H., Sugawara, Y. Jpn. J. Exp. Med. (1980) [Pubmed]
  20. Thyroid hormones and lymphoid cells. Lundell, G., Blomgren, H. Acta radiologica: therapy, physics, biology. (1975) [Pubmed]
  21. The isolation and characterization of four myelin basic proteins from the unbound fraction during CM52 chromatography. Boulias, C., Pang, H., Mastronardi, F., Moscarello, M.A. Arch. Biochem. Biophys. (1995) [Pubmed]
  22. Oligomerization of the Saccharomyces cerevisiae Na+/H+ antiporter Nha1p: implications for its antiporter activity. Mitsui, K., Yasui, H., Nakamura, N., Kanazawa, H. Biochim. Biophys. Acta (2005) [Pubmed]
  23. The SV2 protein of synaptic vesicles is a keratan sulfate proteoglycan. Scranton, T.W., Iwata, M., Carlson, S.S. J. Neurochem. (1993) [Pubmed]
  24. The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants. Clark, A.G., Rohrbaugh, A.L., Otterness, I., Kraus, V.B. Matrix Biol. (2002) [Pubmed]
  25. Helicobacter pylori L-form and patients with chronic gastritis. Wang, K.X., Chen, L. World J. Gastroenterol. (2004) [Pubmed]
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