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Chemical Compound Review

Hoegrass     methyl2-[4-(2,4- dichlorophenoxy)phenoxy]p...

Synonyms: Illoxan, Hoelon, Methyldiclofop, Hoelon 3EC, CHEMBL34474, ...
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Disease relevance of Hoelon

  • Risk of hypospadias increased by 8% for every 0.05-pound increase in estimated exposure to diclofop-methyl use (OR = 1.08; 95% CI, 1.01-1.15) [1].

High impact information on Hoelon

  • For amphipods collected from microcosms exposed to the herbicide 2-[4-(2,4-dichlorophenoxy)phenoxy]propionic acid methyl ester (diclofop-methyl, trade name Hoe Grass), there were detectable levels of only the hydrolysis product, diclofop acid, in the lipid-rich tissue [2].
  • To investigate the in vivo effects of diclofop-methyl, pyrethrins and imazalil, we examined the gene expression of PPARalpha-inducible cytochrome P450 4As (CYP4As) in the liver of female mice intraperitoneally injected with these compounds (</=300 mg/kg) [3].
  • Thus, most of the 200 pesticides tested do not activate PPARalpha or PPARgamma in in vitro assays, but only diclofop-methyl and pyrethrins induce PPARalpha agonistic activity in vivo as well as in vitro [3].
  • Following selection with diclofop-methyl, the five L. rigidum populations exhibited diverse patterns of cross-resistance to ACCase and ALS-inhibiting herbicides, suggesting that different genes or gene combinations were responsible for resistance [4].
  • The LD50 (diclofop-methyl dose required to cause 50% mortality) of the most resistant line was 56-fold greater than that of the original unselected VLR1 population, indicating very large increases in mean population survival after three cycles of selection [5].

Biological context of Hoelon


Associations of Hoelon with other chemical compounds


Analytical, diagnostic and therapeutic context of Hoelon


  1. Agricultural pesticide use and hypospadias in eastern arkansas. Meyer, K.J., Reif, J.S., Veeramachaneni, D.N., Luben, T.J., Mosley, B.S., Nuckols, J.R. Environ. Health Perspect. (2006) [Pubmed]
  2. Tandem mass spectrometry of herbicide residues in lipid-rich tissue. Headley, J.V., Peru, K.M., Arts, M.T. Anal. Chem. (1995) [Pubmed]
  3. In vitro screening of 200 pesticides for agonistic activity via mouse peroxisome proliferator-activated receptor (PPAR)alpha and PPARgamma and quantitative analysis of in vivo induction pathway. Takeuchi, S., Matsuda, T., Kobayashi, S., Takahashi, T., Kojima, H. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  4. High survival frequencies at low herbicide use rates in populations of Lolium rigidum result in rapid evolution of herbicide resistance. Neve, P., Powles, S. Heredity (2005) [Pubmed]
  5. Recurrent selection with reduced herbicide rates results in the rapid evolution of herbicide resistance in Lolium rigidum. Neve, P., Powles, S. Theor. Appl. Genet. (2005) [Pubmed]
  6. Effect of cropping cycles and repeated herbicide applications on the degradation of diclofop-methyl, bentazone, diuron, isoproturon and pendimethalin in soil. Piutti, S., Marchand, A.L., Lagacherie, B., Martin-Laurent, F., Soulas, G. Pest Manag. Sci. (2002) [Pubmed]
  7. Bioluminescence determination of enzyme activity of firefly luciferase in the presence of pesticides. Trajkovska, S., Tosheska, K., Aaron, J.J., Spirovski, F., Zdravkovski, Z. Luminescence : the journal of biological and chemical luminescence. (2005) [Pubmed]
  8. Lolium rigidum, a pool of resistance mechanisms to ACCase inhibitor herbicides. De Prado, J.L., Osuna, M.D., Heredia, A., De Prado, R. J. Agric. Food Chem. (2005) [Pubmed]
  9. Cross-resistance to ACCase inhibitors of Lolium multiflorum, Lolium perenne and Lolium rigidum found in Chile. Michitte, P., Espinoza, N., De Prado, R. Communications in agricultural and applied biological sciences. (2003) [Pubmed]
  10. Determination of diclofop-methyl and diclofop residues in soil and crops by gas chromatography. Liu, W.P., Chen, Z.W., Xu, H.Q., Shi, Y.Y., Chen, Y.Z. J. Chromatogr. (1991) [Pubmed]
  11. Molecular analysis and development of 16S rRNA oligonucleotide probes to characterize a diclofop-methyl-degrading biofilm consortium. Laramée, L., Lawrence, J.R., Greer, C.W. Can. J. Microbiol. (2000) [Pubmed]
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