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Chemical Compound Review

Pyrethrine II     methyl(E)-3-[(1S,3R)-2,2- dimethyl-3...

Synonyms: Pyretrin II, HSDB 6303, LS-58517, ENT 7,543, AC1O5FP0, ...
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Disease relevance of Pyrethrins


High impact information on Pyrethrins


Chemical compound and disease context of Pyrethrins


Biological context of Pyrethrins

  • To investigate the in vivo effects of diclofop-methyl, pyrethrins and imazalil, we examined the gene expression of PPARalpha-inducible cytochrome P450 4As (CYP4As) in the liver of female mice intraperitoneally injected with these compounds (</=300 mg/kg) [14].
  • A case of acute poisoning followed inhalation and cutaneous exposure to an over-the-counter flea and tick insecticide containing 0.15% pyrethrins [11].
  • Pyrethroids which are synthetic derivatives of pyrethrins also modify the kinetics of sodium channels in a very drastic manner [15].
  • Rotenone, azadirachtin, ryanodines, and pyrethrins can be separated by high-performance liquid chromatography, quantified, and confirmed with a diode array detector (DAD) and atmospheric pressure chemical ionization mass spectrometry (APCI-MS) in the select ion-monitoring mode (SIM) [16].
  • Retained oothecae from females treated with an LD50 of fenvalerate (68.70%) or pyrethrins (68.70%) had the greatest percentage hatch [17].

Anatomical context of Pyrethrins


Associations of Pyrethrins with other chemical compounds

  • To elucidate the mode of action for tumor formation, the effect of Pyrethrins on rat thyroid gland, thyroid hormone levels and hepatic thyroxine UDPglucuronosyltransferase activity was investigated [18].
  • Treatment with Pyrethrins and NaPB increased hepatic microsomal thyroxine UDPglucuronosyltransferase activity and serum thyroid stimulating hormone levels (TSH), but reduced serum levels of either thyroxine (T4) and/or triiodothyronine (T3) [18].
  • The biosynthetic pathway to natural pyrethrins in Chrysanthemum cinerariaefolium seedlings was studied using [1-13C]d-glucose as a precursor, with pyrethrin I isolated using HPLC from a leaf extract [19].
  • The household insecticides were, Black Flag (Ant and Roach Killer), Raid (Ant and Roach Killer) and Hot Shot (Wasp and Hornet Killer) containing propoxur, permethrin/pyrethrins and chlorpyrifos/allethrins as their active ingredients respectively [20].
  • Bendiocarb, boric acid powder, and a powder mixture of silica gel + synergized pyrethrins provided excellent control for at least 1 mo, but cockroaches reinfested treated shafts within 3-6 mo [21].

Gene context of Pyrethrins


Analytical, diagnostic and therapeutic context of Pyrethrins


  1. Pyrethrum flowers and pyrethroid insecticides. Casida, J.E. Environ. Health Perspect. (1980) [Pubmed]
  2. A mode of action for induction of liver tumors by Pyrethrins in the rat. Price, R.J., Walters, D.G., Finch, J.M., Gabriel, K.L., Capen, C.C., Osimitz, T.G., Lake, B.G. Toxicol. Appl. Pharmacol. (2007) [Pubmed]
  3. Aquatic effects of aerial spraying for mosquito control over an urban area. Weston, D.P., Amweg, E.L., Mekebri, A., Ogle, R.S., Lydy, M.J. Environ. Sci. Technol. (2006) [Pubmed]
  4. Evaluation of the herpes simplex virus antiviral activity of pyrethrins. Stanberry, L.R., Bernstein, D.I., Myers, M.G. Antiviral Res. (1986) [Pubmed]
  5. Pyrolysing insecticidal coils: air pollution by polycyclic aromatic hydrocarbons and other mutagens detected by the Salmonella/microsome test. Lazaridis, G., Löfroth, G. Environ. Pollut. (1987) [Pubmed]
  6. Direct on-line continuous supercritical fluid extraction and HPLC of aqueous pyrethrins solutions. Pól, J., Wenclawiak, B.W. Anal. Chem. (2003) [Pubmed]
  7. Treatment of infestation with Phthirus pubis: comparative efficacies of synergized pyrethrins and gamma-benzene hexachloride. Newsom, J.H., Fiore, J.L., Hackett, E. Sexually transmitted diseases. (1979) [Pubmed]
  8. Pyrethroids, pyrethrins, and piperonyl butoxide in sediments by high-resolution gas chromatography/high-resolution mass spectrometry. Woudneh, M.B., Oros, D.R. Journal of chromatography. A. (2006) [Pubmed]
  9. Toxicity of natural pyrethrins and five pyrethroids to fish. Mauck, W.L., Olson, L.E. Arch. Environ. Contam. Toxicol. (1976) [Pubmed]
  10. A general noninteractive multiple toxicity model including probit, logit, and Weibull transformations. Christensen, E.R., Chen, C.Y. Biometrics (1985) [Pubmed]
  11. Pyrethrin poisoning from commercial-strength flea and tick spray. Paton, D.L., Walker, J.S. The American journal of emergency medicine. (1988) [Pubmed]
  12. Efficacy and tolerability of a new synergized pyrethrins thermofobic foam in comparison with benzyl benzoate in the treatment of scabies in convicts: the ISAC study (Studio Della scabbia in ambiente carcerario). Biele, M., Campori, G., Colombo, R., De Giorgio, G., Frascione, P., Sali, R., Starnini, G., Milani, M. Journal of the European Academy of Dermatology and Venereology : JEADV. (2006) [Pubmed]
  13. Toxicity of several insecticide formulations against adult German cockroaches (Dictyoptera: Blattellidae). Abd-Elghafar, S.F., Appel, A.G., Mack, T.P. J. Econ. Entomol. (1990) [Pubmed]
  14. In vitro screening of 200 pesticides for agonistic activity via mouse peroxisome proliferator-activated receptor (PPAR)alpha and PPARgamma and quantitative analysis of in vivo induction pathway. Takeuchi, S., Matsuda, T., Kobayashi, S., Takahashi, T., Kojima, H. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  15. Toxins that modulate the sodium channel gating mechanism. Narahashi, T. Ann. N. Y. Acad. Sci. (1986) [Pubmed]
  16. Fast and versatile multiresidue method for the analysis of botanical insecticides on fruits and vegetables by HPLC/DAD/MS. Caboni, P., Sarais, G., Angioni, A., Garau, V.L., Cabras, P. J. Agric. Food Chem. (2005) [Pubmed]
  17. Effects of several insecticide formulations on oothecal drop and hatchability in German cockroaches (Dictyoptera: Blattellidae). Abd-Elghafar, S.F., Appel, A.G., Mack, T.P. J. Econ. Entomol. (1991) [Pubmed]
  18. A mode of action for induction of thyroid gland tumors by Pyrethrins in the rat. Finch, J.M., Osimitz, T.G., Gabriel, K.L., Martin, T., Henderson, W.J., Capen, C.C., Butler, W.H., Lake, B.G. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  19. Biosynthesis of pyrethrin I in seedlings of Chrysanthemum cinerariaefolium. Matsuda, K., Kikuta, Y., Haba, A., Nakayama, K., Katsuda, Y., Hatanaka, A., Komai, K. Phytochemistry (2005) [Pubmed]
  20. Penetration of household insecticides through different types of textile fabrics. Saleh, M.A., Kamel, A., el-Demerdash, A., Jones, J. Chemosphere (1998) [Pubmed]
  21. Control of American cockroaches (Dictyoptera: Blattidae) in sewers. Rust, M.K., Reierson, D.A., Hansgen, K.H. J. Med. Entomol. (1991) [Pubmed]
  22. Comparative in vitro pediculicidal efficacy of treatments in a resistant head lice population in the United States. Meinking, T.L., Serrano, L., Hard, B., Entzel, P., Lemard, G., Rivera, E., Villar, M.E. Archives of dermatology. (2002) [Pubmed]
  23. Effect of sunscreen and antioxidant on the stability of pyrethrin formulations. Minello, E.V., Lai, F., Zonchello, M.T., Melis, M., Russo, M., Cabras, P. J. Agric. Food Chem. (2005) [Pubmed]
  24. Use of laminar cup liners for the preparation of fatty samples for pesticide analysis. Zehringer, M. Food additives and contaminants. (2001) [Pubmed]
  25. Residues and half-lives of pyrethrins on field-grown pepper and tomato. Antonious, G.F. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. (2004) [Pubmed]
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