Disease relevance of C12496

• Intracisternal dimer X: toxicity and prophylaxis [1].
• Although Dimer X is said to be a low toxic water soluble contrast medium, epileptic seizures sometimes occur during or after Dimer X ventriculography [1].
• Although osseous spinal stenosis was rarely seen, fibrous spinal stenosis was demonstrated in 6% of 850 lumbar myelograms done with 10 ml doses of water-soluble Dimer-X (Maybaker) [2].
• This is followed by a discussion of their advantages and complications, as well as a case report of convulsive segmental myoclonus, hypotension, and death after myelography associated with the use of dimeglumine locarmate (Dimer-X) [3].
• X-ray examination of the intracranial ventricles with Dimer X made it possible to make the diagnosis of obstructive hydrocephalus due to a mass lesion of the midbrain and abnormal intrasellar recess of the third ventricle in a 34 year old female patient [4].

High impact information on C12496

• Fragments D1, D1 dimer, X, and Y in low concentrations bound to macrophages with high affinity (Kd = 23 to 73 X 10(-11) mol/L) [5].
• Amipaque myelography. The side effects compared with Dimer X [6].
• In one of them after investigation with Dimer X, intense cramps in the lower extremities caused a fracture of the femoral neck within a few hours after the investigation [7].
• The incidence of abdominal pain during hysterosalpingography was assessed from replies to postal questionnaires completed by 42 patients receiving Diaginol Viscous and 23 patients receiving Dimer X: the questionnaires were analysed using a double-blind technique [8].
• Experience with Dimer-X myelography in 3000 patients provides some indication of the scope of examination of the lumbar, thoracic and cervical segments of the spinal canal with a water-soluble contrast medium [9].

Anatomical context of C12496

• In the clinical studies, ventriculography with 1-5 ml Dimer-X, performed on 17 cases, aged 8 months to 62 years, with diseases of the central nervous system, produced ventriculograms of good diagnostic value with no side effects, such as convulsions, apart from mild headache or vomiting in 4 instances [10].
• Meglumine iocarmate (Dimer-X) may be accidentally put into the subarachnoid space because of suboptimal technique during ventriculography [11].

Analytical, diagnostic and therapeutic context of C12496

• Double contrast knee arthrography. Some new points of technique including the use of Dimer X [12].
• Dimer X in hysterosalpingography [8].
• Morphological studies of the ventricles and histological examinations of the ventricular walls 1 month after intraventricular injections of Dimer-X showed no abnormalities [10].
• In the animal experiments, 1.5 ml and 2.0 ml of Dimer-X were injected into the ventricles of 7 dogs [10].
• The diagnosis was established by B-mode or real-time brain sonography, in association with another neuroradiological procedure (computed tomography, ventriculography with air or Dimer-X, cerebral angiography) [13].

References