The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

pOH-Ph-CH2CHO     2-(4-hydroxyphenyl)ethanal

Synonyms: AG-L-64027, CHEBI:15621, HMDB03767, ANW-61912, AK-77585, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of HYDROXYACETOPHENONE


High impact information on HYDROXYACETOPHENONE


Biological context of HYDROXYACETOPHENONE

  • Molecular modeling studies were carried out by a combined use of conformational analysis and 3D-QSAR methods of identify molecular features common to a series of hydroxyacetophenone (HAP) and non-hydroxyacetophenone (non-HAP) peptide leukotriene (pLT) receptor antagonists [7].

Anatomical context of HYDROXYACETOPHENONE

  • The present study examined whether VLDL modification by the reactive aldehyde p-hydroxyphenylacetaldehyde (pHA) enhances cholesteryl ester (CE) accumulation by J774A.1 macrophages. pHA is the major product derived from the oxidation of L-tyrosine by myeloperoxidase and is a component of human atherosclerotic lesions [8].
  • Based on different choleretic activities of hydroxyacetophenone analogues including 4-mono; 2,6-di and 2,4,6-trihydroxy-acetophenone (MHA, DHA and THA), the present study aims to determine if these compounds stimulated vesicular transport in hepatocytes [2].

Associations of HYDROXYACETOPHENONE with other chemical compounds


Analytical, diagnostic and therapeutic context of HYDROXYACETOPHENONE


  1. Conversion of (+/-)-synephrine into p-hydroxyphenylacetaldehyde by Arthrobacter synephrinum. A novel enzymic reaction. Veeraswamy, M., Devi, N.A., Kutty, R.K., Rao, P.V. Biochem. J. (1976) [Pubmed]
  2. Differential effects of hydroxyacetophenone analogues on the transcytotic vesicular pathway in rat liver. Tradtrantip, L., Boyer, J.L., Suksamrarn, A., Piyachaturawat, P. Eur. J. Pharmacol. (2006) [Pubmed]
  3. 2-nitro-3-(p-hydroxyphenyl)propionate and aci-1-nitro-2-(p-hydroxyphenyl)ethane, two intermediates in the biosynthesis of the cyanogenic glucoside dhurrin in Sorghum bicolor (L.) Moench. Halkier, B.A., Lykkesfeldt, J., Møller, B.L. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  4. p-Hydroxyphenylacetaldehyde, the major product of L-tyrosine oxidation by the myeloperoxidase-H2O2-chloride system of phagocytes, covalently modifies epsilon-amino groups of protein lysine residues. Hazen, S.L., Gaut, J.P., Hsu, F.F., Crowley, J.R., d'Avignon, A., Heinecke, J.W. J. Biol. Chem. (1997) [Pubmed]
  5. p-Hydroxyphenylacetaldehyde is the major product of L-tyrosine oxidation by activated human phagocytes. A chloride-dependent mechanism for the conversion of free amino acids into reactive aldehydes by myeloperoxidase. Hazen, S.L., Hsu, F.F., Heinecke, J.W. J. Biol. Chem. (1996) [Pubmed]
  6. Cytochrome P-450TYR is a multifunctional heme-thiolate enzyme catalyzing the conversion of L-tyrosine to p-hydroxyphenylacetaldehyde oxime in the biosynthesis of the cyanogenic glucoside dhurrin in Sorghum bicolor (L.) Moench. Sibbesen, O., Koch, B., Halkier, B.A., Møller, B.L. J. Biol. Chem. (1995) [Pubmed]
  7. A proposed common spatial pharmacophore and the corresponding active conformations of some peptide leukotriene receptor antagonists. Hariprasad, V., Kulkarni, V.M. J. Comput. Aided Mol. Des. (1996) [Pubmed]
  8. Modification of type III VLDL, their remnants, and VLDL from ApoE-knockout mice by p-hydroxyphenylacetaldehyde, a product of myeloperoxidase activity, causes marked cholesteryl ester accumulation in macrophages. Whitman, S.C., Hazen, S.L., Miller, D.B., Hegele, R.A., Heinecke, J.W., Huff, M.W. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
  9. Elevated levels of protein-bound p-hydroxyphenylacetaldehyde, an amino-acid-derived aldehyde generated by myeloperoxidase, are present in human fatty streaks, intermediate lesions and advanced atherosclerotic lesions. Hazen, S.L., Gaut, J.P., Crowley, J.R., Hsu, F.F., Heinecke, J.W. Biochem. J. (2000) [Pubmed]
  10. Metabolism of amines in the isolated perfused mesenteric arterial bed of the rat. Elliott, J., Callingham, B.A., Sharman, D.F. Br. J. Pharmacol. (1989) [Pubmed]
  11. Spiroiminodihydantoin is a major product in the photooxidation of 2'-deoxyguanosine by the triplet states and oxyl radicals generated from hydroxyacetophenone photolysis and dioxetane thermolysis. Adam, W., Arnold, M.A., Grüne, M., Nau, W.M., Pischel, U., Saha-Möller, C.R. Org. Lett. (2002) [Pubmed]
  12. The biosynthesis of cyanogenic glucosides in higher plants. The (E)- and (Z)-isomers of p-hydroxyphenylacetaldehyde oxime as intermediates in the biosynthesis of dhurrin in Sorghum bicolor (L.) Moench. Halkier, B.A., Olsen, C.E., Møller, B.L. J. Biol. Chem. (1989) [Pubmed]
WikiGenes - Universities