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Chemical Compound Review:

AG-K-90848 3-nitro-7-(prop-2- enoxymethyl)-6-oxa-1,4...

Synonyms: ACMC-20as72, AC1LAI7K, CTK4B5692, AR-1H2391, AC1Q208N, ...

Taburet, A.M. et al., Taburet, A.M. et al., Urtasun, R. et al., Stetter, M. et al., Tenenbaum, H. et al., et al.

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Disease relevance of Nitroimidazole derivative

BACKGROUND: Benznidazole, a nitroimidazole derivative, has been recommended for the treatment of acute and congenital Trypanosoma cruzi infection (Chagas' disease) [1].
Pharmacokinetics of ornidazole, a nitroimidazole derivative, was studied after intravenous injection in 10 patients with severe alcoholic cirrhosis and 10 healthy volunteers [2].
Pharmacokinetics of ornidazole, a nitroimidazole derivative, was investigated after intravenous injection in 3 groups of 10 patients with different hepatic diseases: hepatitis, noncholestatic cirrhosis and extrahepatic cholestasis [3].
Pertussis toxin did not diminish the nitroimidazole derivative effect on cAMP formation [4].
As a continuation of a previous controlled trial using "high-dose" metronidazole as a specific sensitizer of hypoxic cells, we used a more efficient nitroimidazole derivative (misonidazole, MISO) in combination with higher doses of radiation in patients with supratentorial high-grade astrocytomas [5].

High impact information on Nitroimidazole derivative

Side effects due to azathioprine (the nitroimidazole derivative of 6-mercaptopurine) can be classified as toxic (myelosuppression, hepatotoxicity) and idiosyncratic (fever, rigors, arthralgias, pneumonitis, and gastrointestinal symptoms) [6].
A nitroimidazole derivative, PR-350, enhances the killing of pancreatic cancer cells exposed to high-dose irradiation under hypoxia [7].
The purpose of this study was to measure secnidazole (another nitroimidazole derivative) concentrations in plasma and gingival crevicular fluid (GCF) after intake of a single oral dose [8].
The kinetics in the rat of a new nitroimidazole derivative [9].

References

Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection. de Andrade, A.L., Zicker, F., de Oliveira, R.M., Almeida Silva, S., Luquetti, A., Travassos, L.R., Almeida, I.C., de Andrade, S.S., de Andrade, J.G., Martelli, C.M. Lancet (1996) [Pubmed]
Pharmacokinetics of ornidazole in patients with severe liver cirrhosis. Taburet, A.M., Delion, F., Attali, P., Thebault, J.J., Singlas, E. Clin. Pharmacol. Ther. (1986) [Pubmed]
Pharmacokinetics of ornidazole in patients with acute viral hepatitis, alcoholic cirrhosis, and extrahepatic cholestasis. Taburet, A.M., Attali, P., Bourget, P., Etienne, J.P., Singlas, E. Clin. Pharmacol. Ther. (1989) [Pubmed]
Nitroimidazole derivatives inhibit anterior pituitary cell function apparently by a direct effect on the catalytic subunit of the adenylate cyclase holoenzyme. Stalla, G.K., Stalla, J., von Werder, K., Müller, O.A., Gerzer, R., Höllt, V., Jakobs, K.H. Endocrinology (1989) [Pubmed]
Radiation and nitroimidazoles in supratentorial high grade gliomas: a second clinical trial. Urtasun, R., Feldstein, M.L., Partington, J., Tanasichuk, H., Miller, J.D., Russell, D.B., Agboola, O., Mielke, B. Br. J. Cancer (1982) [Pubmed]
Azathioprine hypersensitivity mimicking Goodpasture's syndrome. Stetter, M., Schmidl, M., Krapf, R. Am. J. Kidney Dis. (1994) [Pubmed]
A nitroimidazole derivative, PR-350, enhances the killing of pancreatic cancer cells exposed to high-dose irradiation under hypoxia. Mizumoto, K., Qian, L.W., Zhang, L., Nagai, E., Kura, S., Tanaka, M. J. Radiat. Res. (2002) [Pubmed]
Secnidazole concentrations in plasma and crevicular fluid after a single oral dose. Tenenbaum, H., Cuisinier, F.J., Le Liboux, A., Pichard, E., Montay, G., Frydman, A. Journal of clinical periodontology. (1993) [Pubmed]
The kinetics in the rat of a new nitroimidazole derivative. Cerretani, D., Runci, F.M., Segre, G. Drugs under experimental and clinical research. (1985) [Pubmed]

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