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MeSH Review

Gingival Crevicular Fluid

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Disease relevance of Gingival Crevicular Fluid


High impact information on Gingival Crevicular Fluid

  • Interestingly, gingival crevicular fluid samples from diseased periodontal sites but not samples from healthy periodontal sites contained fragments of transferrin [6].
  • This may help explain the presence of Th1-associated cytokines in gingival crevicular fluid (GCF) from LagP patients and the high levels of IgG2 in their serum and GCF that is reactive with A. actinomycetemcomitans [7].
  • Collectively, these studies have identified distinct forms of latent and active MMP-8 in gingival crevicular fluid that appear to result from a unique activation mechanism that occurs in periodontitis [8].
  • Since azithromycin has favorable pharmacokinetic properties, including excellent distribution into tissues, it could be expected to pass into gingival crevicular fluid at levels sufficient to inhibit A. actinomycetemcomitans in vivo [9].
  • The inhibitory activity was not due to a toxic effect on the thymocytes since IL-1 alpha-depleted gingival crevicular fluid did not affect the incorporation of [3H]thymidine in either the presence or absence of concanavalin A [2].

Chemical compound and disease context of Gingival Crevicular Fluid


Biological context of Gingival Crevicular Fluid


Anatomical context of Gingival Crevicular Fluid


Associations of Gingival Crevicular Fluid with chemical compounds


Gene context of Gingival Crevicular Fluid


Analytical, diagnostic and therapeutic context of Gingival Crevicular Fluid


  1. Relationship between gingival crevicular fluid and serum antibody titers in young adults with generalized and localized periodontitis. Tew, J.G., Marshall, D.R., Burmeister, J.A., Ranney, R.R. Infect. Immun. (1985) [Pubmed]
  2. An interleukin-1 inhibitor in gingival crevicular fluid of patients with chronic inflammatory periodontal disease. Kabashima, H., Maeda, K., Iribe, H., Yamashita, K., Hirofuji, T., Iwamoto, Y., Aono, M. Infect. Immun. (1991) [Pubmed]
  3. Lactate dehydrogenase, beta-glucuronidase and arylsulfatase activity in gingival crevicular fluid associated with experimental gingivitis in man. Lamster, I.B., Vogel, R.I., Hartley, L.J., DeGeorge, C.A., Gordon, J.M. J. Periodontol. (1985) [Pubmed]
  4. Periodontal variables affecting nifedipine sequestration in gingival crevicular fluid. Ellis, J.S., Seymour, R.A., Thomason, J.M., Butler, T.J., Idle, J.R. J. Periodont. Res. (1995) [Pubmed]
  5. Microbial factors and gingival crevicular fluid aspartate aminotransferase levels. A cross-sectional study. Smith, A.J., Alexander, M., Mackenzie, D., Lennon, A., Riggio, M.P., MacFarlane, T.W. Journal of clinical periodontology. (1998) [Pubmed]
  6. Cleavage of human transferrin by Porphyromonas gingivalis gingipains promotes growth and formation of hydroxyl radicals. Goulet, V., Britigan, B., Nakayama, K., Grenier, D. Infect. Immun. (2004) [Pubmed]
  7. Dendritic cells stimulated with Actinobacillus actinomycetemcomitans elicit rapid gamma interferon responses by natural killer cells. Kikuchi, T., Hahn, C.L., Tanaka, S., Barbour, S.E., Schenkein, H.A., Tew, J.G. Infect. Immun. (2004) [Pubmed]
  8. Activation of neutrophil collagenase in periodontitis. Romanelli, R., Mancini, S., Laschinger, C., Overall, C.M., Sodek, J., McCulloch, C.A. Infect. Immun. (1999) [Pubmed]
  9. In vitro activity of azithromycin compared with that of erythromycin against Actinobacillus actinomycetemcomitans. Pajukanta, R., Asikainen, S., Saarela, M., Alaluusua, S., Jousimies-Somer, H. Antimicrob. Agents Chemother. (1992) [Pubmed]
  10. Association of gingival crevicular fluid aspartate aminotransferase levels with histopathology during ligature-induced periodontitis in the beagle dog. Cohen, R.L., Alves, M.E., Crawford, J.M., McSwiggin, T., Chambers, D.A. J. Dent. Res. (1991) [Pubmed]
  11. Heterogeneity of IgG glycosylation in adult periodontal disease. Novak, J., Tomana, M., Shah, G.R., Brown, R., Mestecky, J. J. Dent. Res. (2005) [Pubmed]
  12. Calprotectin in gingival crevicular fluid correlates with clinical and biochemical markers of periodontal disease. Kido, J., Nakamura, T., Kido, R., Ohishi, K., Yamauchi, N., Kataoka, M., Nagata, T. Journal of clinical periodontology. (1999) [Pubmed]
  13. Cellular source and tetracycline-inhibition of gingival crevicular fluid collagenase of patients with labile diabetes mellitus. Sorsa, T., Ingman, T., Suomalainen, K., Halinen, S., Saari, H., Konttinen, Y.T., Uitto, V.J., Golub, L.M. Journal of clinical periodontology. (1992) [Pubmed]
  14. Adjunctive subantimicrobial dose doxycycline: effect on clinical parameters and gingival crevicular fluid transforming growth factor-beta levels in severe, generalized chronic periodontitis. Gürkan, A., Cinarcik, S., Hüseyinov, A. Journal of clinical periodontology. (2005) [Pubmed]
  15. Impact of increased occlusal contact, interleukin-1 genotype, and periodontitis severity on gingival crevicular fluid IL-1beta levels. McDevitt, M.J., Russell, C.M., Schmid, M.J., Reinhardt, R.A. J. Periodontol. (2003) [Pubmed]
  16. Kinetics of spiramycin/metronidazole (Rodogyl) in human gingival crevicular fluid, saliva and blood. Rotzetter, P.A., Le Liboux, A., Pichard, E., Cimasoni, G. Journal of clinical periodontology. (1994) [Pubmed]
  17. Comparison of alveolar bone loss, alveolar bone density and second metacarpal bone density, salivary and gingival crevicular fluid interleukin-6 concentrations in healthy premenopausal and postmenopausal women on estrogen therapy. Streckfus, C.F., Johnson, R.B., Nick, T., Tsao, A., Tucci, M. J. Gerontol. A Biol. Sci. Med. Sci. (1997) [Pubmed]
  18. Levels of tissue inhibitor of metalloproteinases-1 and matrix metalloproteinases-1 and -8 in gingival crevicular fluid following treatment with enamel matrix derivative (EMDOGAIN). Okuda, K., Miyazaki, A., Momose, M., Murata, M., Nomura, T., Kubota, T., Wolff, L.F., Yoshie, H. J. Periodont. Res. (2001) [Pubmed]
  19. Tetracycline inhibition identifies the cellular origin of interstitial collagenases in human periodontal diseases in vivo. Suomalainen, K., Sorsa, T., Ingman, T., Lindy, O., Golub, L.M. Oral Microbiol. Immunol. (1992) [Pubmed]
  20. Cathepsin C, matrix metalloproteinases, and their tissue inhibitors in gingiva and gingival crevicular fluid from periodontitis-affected patients. Soell, M., Elkaim, R., Tenenbaum, H. J. Dent. Res. (2002) [Pubmed]
  21. Altered relation between granulocyte elastase and alpha-2-macroglobulin in gingival crevicular fluid from sites with periodontal destruction. Gustafsson, A., Asman, B., Bergström, K. Journal of clinical periodontology. (1994) [Pubmed]
  22. Inhibition of epithelial cell matrix metalloproteinases by tetracyclines. Nip, L.H., Uitto, V.J., Golub, L.M. J. Periodont. Res. (1993) [Pubmed]
  23. Expression of interleukin-2 receptor and HLA-DR on lymphocyte subsets of gingival crevicular fluid in patients with periodontitis. Takeuchi, Y., Yoshie, H., Hara, K. J. Periodont. Res. (1991) [Pubmed]
  24. Gingival crevicular fluid levels of clindamycin compared with its minimal inhibitory concentrations for periodontal bacteria. Walker, C.B., Gordon, J.M., Cornwall, H.A., Murphy, J.C., Socransky, S.S. Antimicrob. Agents Chemother. (1981) [Pubmed]
  25. Single-dose concentrations of tinidazole in gingival crevicular fluid, serum, and gingival tissue in adults with periodontitis. Liew, V., Mack, G., Tseng, P., Cvejic, M., Hayden, M., Buchanan, N. J. Dent. Res. (1991) [Pubmed]
  26. Investigations into black extrinsic tooth stain. Reid, J.S., Beeley, J.A., MacDonald, D.G. J. Dent. Res. (1977) [Pubmed]
  27. Salivary PAF levels correlate with the severity of periodontal inflammation. Garito, M.L., Prihoda, T.J., McManus, L.M. J. Dent. Res. (1995) [Pubmed]
  28. Salivary non-immunoglobulin agglutinin inhibits human leukocyte elastase digestion of acidic proline-rich salivary proteins. Boackle, R.J., Dutton, S.L., Fei, H., Vesely, J., Malamud, D., Furness, A.R. J. Dent. Res. (2001) [Pubmed]
  29. Effects of phase I periodontal treatment on gingival crevicular fluid levels of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1. Tüter, G., Kurtiş, B., Serdar, M. J. Periodontol. (2002) [Pubmed]
  30. Levels of Porphyromonas gingivalis Fimbriae and inflammatory cytokines in gingival crevicular fluid from adult human subjects. Hirose, K., Isogai, E., Miura, H., Ueda, I. Microbiol. Immunol. (1997) [Pubmed]
  31. Plasminogen activators and plasminogen activator inhibitors in gingival crevicular fluid of cyclosporin A-treated patients. Buduneli, N., Buduneli, E., Ciotanar, S., Atilla, G., Lappin, D., Kinane, D. Journal of clinical periodontology. (2004) [Pubmed]
  32. Norepinephrine stimulates calprotectin expression in human monocytic cells. Kido, J., Hayashi, N., Kataoka, M., Shinohara, Y., Nagata, T. J. Periodont. Res. (2006) [Pubmed]
  33. Interleukin (IL)-1 beta, IL-6, tumor necrosis factor-alpha, epidermal growth factor, and beta 2-microglobulin levels are elevated in gingival crevicular fluid during human orthodontic tooth movement. Uematsu, S., Mogi, M., Deguchi, T. J. Dent. Res. (1996) [Pubmed]
  34. IgG and IgA subclass mRNA-bearing plasma cells in periodontitis gingival tissue and immunoglobulin levels in the gingival crevicular fluid. Takahashi, K., Mooney, J., Frandsen, E.V., Kinane, D.F. Clin. Exp. Immunol. (1997) [Pubmed]
  35. Physicochemical characterization and preliminary in vivo efficacy of bioadhesive, semisolid formulations containing flurbiprofen for the treatment of gingivitis. Jones, D.S., Irwin, C.R., Woolfson, A.D., Djokic, J., Adams, V. Journal of pharmaceutical sciences. (1999) [Pubmed]
  36. Automated enzyme immunoassay to measure prostaglandin E2 in gingival crevicular fluid. Nelson, S.L., Hynd, B.A., Pickrum, H.M. J. Periodont. Res. (1992) [Pubmed]
  37. Analysis of aspartate aminotransferase in gingival crevicular fluid assessed by using PocketWatch: a longitudinal study with initial therapy. Shimada, K., Mizuno, T., Ohshio, K., Kamaga, M., Murai, S., Ito, K. Journal of clinical periodontology. (2000) [Pubmed]
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