Chemical Compound Review:
Rochagan N-benzyl-2-(2-nitroimidazol- 1-yl)ethanamide
Synonyms:
Radanil, Ragonil, Benznidazol, BENZNIDAZOLE, benzonidazol, ...
- Should benznidazole be used in chronic Chagas' disease? Bestetti, R.B. Lancet (1997)
- Heart transplantation in Chagas' disease. 10 years after the initial experience. de Carvalho, V.B., Sousa, E.F., Vila, J.H., da Silva, J.P., Caiado, M.R., Araujo, S.R., Macruz, R., Zerbini, E.J. Circulation (1996)
- Effect of partition coefficient on the ability of nitroimidazoles to enhance the cytotoxicity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea. Hirst, D.G., Brown, J.M., Hazlehurst, J.L. Cancer Res. (1983)
- In vivo potentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea by the radiation sensitizer benznidazole. Siemann, D.W., Morrissey, S., Wolf, K. Cancer Res. (1983)
- Activities of the triazole derivative SCH 56592 (posaconazole) against drug-resistant strains of the protozoan parasite Trypanosoma (Schizotrypanum) cruzi in immunocompetent and immunosuppressed murine hosts. Molina, J., Martins-Filho, O., Brener, Z., Romanha, A.J., Loebenberg, D., Urbina, J.A. Antimicrob. Agents Chemother. (2000)
- Trypanocidal drug benznidazole impairs lipopolysaccharide induction of macrophage nitric oxide synthase gene transcription through inhibition of NF-kappaB activation. Piaggio, E., Sancéau, J., Revelli, S., Bottasso, O., Wietzerbin, J., Serra, E. J. Immunol. (2001)
- The Anti-Trypanosoma cruzi Activity of Posaconazole in a Murine Model of Acute Chagas' Disease Is Less Dependent on Gamma Interferon than That of Benznidazole. Ferraz, M.L., Gazzinelli, R.T., Alves, R.O., Urbina, J.A., Romanha, A.J. Antimicrob. Agents Chemother. (2007)
- Antibacterial activities of the antiparasitic drugs nifurtimox and benznidazole. Hof, H. Antimicrob. Agents Chemother. (1989)
- Proinflammatory and cytotoxic effects of hexadecylphosphocholine (miltefosine) against drug-resistant strains of Trypanosoma cruzi. Saraiva, V.B., Gibaldi, D., Previato, J.O., Mendonça-Previato, L., Bozza, M.T., Freire-De-Lima, C.G., Heise, N. Antimicrob. Agents Chemother. (2002)
- A phase II study of CCNU with benznidazole for metastatic malignant melanoma. Bleehen, N.M., Roberts, J.T., Newman, H.F. Int. J. Radiat. Oncol. Biol. Phys. (1986)
- A combination of benznidazole and ketoconazole enhances efficacy of chemotherapy of experimental Chagas' disease. Araújo, M.S., Martins-Filho, O.A., Pereira, M.E., Brener, Z. J. Antimicrob. Chemother. (2000)
- Benznidazole therapy in Trypanosoma cruzi-infected mice blocks thymic involution and apoptosis of CD4+CD8+ double-positive thymocytes. Olivieri, B.P., Farias-De-Oliveira, D.A., Araujo-Jorge, T.C., Cotta-de-Almeida, V. Antimicrob. Agents Chemother. (2005)
- Chemotherapy with benznidazole and itraconazole for mice infected with different Trypanosoma cruzi clonal genotypes. Toledo, M.J., Bahia, M.T., Carneiro, C.M., Martins-Filho, O.A., Tibayrenc, M., Barnabé, C., Tafuri, W.L., de Lana, M. Antimicrob. Agents Chemother. (2003)
- Preclinical pharmacokinetics of benznidazole. Workman, P., White, R.A., Walton, M.I., Owen, L.N., Twentyman, P.R. Br. J. Cancer (1984)
- The pharmacokinetics in mice and dogs of nitroimidazole radiosensitizers and chemosensitizers more lipophilic than misonidazole. White, R., Workman, P., Owen, L. Int. J. Radiat. Oncol. Biol. Phys. (1982)
- Benznidazole treatment following acute Trypanosoma cruzi infection triggers CD8+ T-cell expansion and promotes resistance to reinfection. Olivieri, B.P., Cotta-De-Almeida, V., Araújo-Jorge, T. Antimicrob. Agents Chemother. (2002)
- Buthionine sulfoximine increases the toxicity of nifurtimox and benznidazole to Trypanosoma cruzi. Faundez, M., Pino, L., Letelier, P., Ortiz, C., López, R., Seguel, C., Ferreira, J., Pavani, M., Morello, A., Maya, J.D. Antimicrob. Agents Chemother. (2005)
- Heat-stimulated nitroreductive bioactivation of the 2-nitroimidazole benznidazole in vitro. Walton, M.I., Bleehen, N.M., Workman, P. Biochem. Pharmacol. (1987)
- Misonidazole and benznidazole inhibit hydroxylation of CCNU by mouse liver microsomal cytochrome P-450 in vitro. Lee, F.Y., Workman, P., Cheeseman, K.H. Biochem. Pharmacol. (1987)
- Cytochrome P-450, reductive metabolism, and cell injury. De Groot, H., Sies, H. Drug Metab. Rev. (1989)
- Molecular enzymology of the reductive bioactivation of hypoxic cell cytotoxins. Walton, M.I., Wolf, C.R., Workman, P. Int. J. Radiat. Oncol. Biol. Phys. (1989)
- Inhibition of Trypanosoma cruzi and T. brucei NADH fumarate reductase by benznidazole and anthelmintic imidazole derivatives. Turrens, J.F., Watts, B.P., Zhong, L., Docampo, R. Mol. Biochem. Parasitol. (1996)
- Experimental chemotherapy against Trypanosoma cruzi infection: essential role of endogenous interferon-gamma in mediating parasitologic cure. Romanha, A.J., Alves, R.O., Murta, S.M., Silva, J.S., Ropert, C., Gazzinelli, R.T. J. Infect. Dis. (2002)
- Long-lasting antibodies detected by a trans-sialidase inhibition assay of sera from parasite-free, serologically cured chagasic patients. Leguizamón, M.S., Russomando, G., Luquetti, A., Rassi, A., Almirón, M., González-Cappa, S.M., Frasch, A.C., Campetella, O. J. Infect. Dis. (1997)
- Treatment with benznidazole during the chronic phase of experimental Chagas' disease decreases cardiac alterations. Garcia, S., Ramos, C.O., Senra, J.F., Vilas-Boas, F., Rodrigues, M.M., Campos-de-Carvalho, A.C., Ribeiro-Dos-Santos, R., Soares, M.B. Antimicrob. Agents Chemother. (2005)
- Deletion of the Trypanosoma brucei Superoxide Dismutase Gene sodb1 Increases Sensitivity to Nifurtimox and Benznidazole. Prathalingham, S.R., Wilkinson, S.R., Horn, D., Kelly, J.M. Antimicrob. Agents Chemother. (2007)
- Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection. de Andrade, A.L., Zicker, F., de Oliveira, R.M., Almeida Silva, S., Luquetti, A., Travassos, L.R., Almeida, I.C., de Andrade, S.S., de Andrade, J.G., Martelli, C.M. Lancet (1996)
- Stimulation by localized tumor hyperthermia of reductive bioactivation of 2-nitroimidazole benznidazole in mice. Walton, M.I., Bleehen, N.M., Workman, P. Cancer Res. (1989)
- Use of polymerase chain reaction to diagnose the fifth reported US case of autochthonous transmission of Trypanosoma cruzi, in Tennessee, 1998. Herwaldt, B.L., Grijalva, M.J., Newsome, A.L., McGhee, C.R., Powell, M.R., Nemec, D.G., Steurer, F.J., Eberhard, M.L. J. Infect. Dis. (2000)
- PCR assay for monitoring Trypanosoma cruzi parasitemia in childhood after specific chemotherapy. Galvão, L.M., Chiari, E., Macedo, A.M., Luquetti, A.O., Silva, S.A., Andrade, A.L. J. Clin. Microbiol. (2003)
- A randomized study of CCNU with and without benznidazole in the treatment of recurrent grades 3 and 4 astrocytoma. Report to the Medical Research Council by the Brain Tumor Working Party. Bleehen, N.M., Freedman, L.S., Stenning, S.P. Int. J. Radiat. Oncol. Biol. Phys. (1989)