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Chemical Compound Review

Flagentyl     1-(2-methyl-5-nitro-imidazol- 1-yl)propan-2-ol

Synonyms: Secnidazol, Secnidazole, Secnidazolum, Secnidal (TN), S2537_Selleck, ...
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Disease relevance of Secnidazole


High impact information on Secnidazole


Chemical compound and disease context of Secnidazole


Biological context of Secnidazole


Anatomical context of Secnidazole

  • These results show that the rate and extent-absorption of secnidazole are slightly higher in blood than in GCF, but the elimination of the drug is similar in the two body fluids [13].

Associations of Secnidazole with other chemical compounds


Analytical, diagnostic and therapeutic context of Secnidazole


  1. Secnidazole. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic use in the management of protozoal infections and bacterial vaginosis. Gillis, J.C., Wiseman, L.R. Drugs (1996) [Pubmed]
  2. Lansoprazole and secnidazole with clarithromycin, amoxycillin or pefloxacin in the eradication of Helicobacter pylori in a developing country. Ahuja, V., Dhar, A., Bal, C., Sharma, M.P. Aliment. Pharmacol. Ther. (1998) [Pubmed]
  3. A randomized trial comparing mebendazole and secnidazole for the treatment of giardiasis. Escobedo, A.A., Cañete, R., Gonzalez, M.E., Pareja, A., Cimerman, S., Almirall, P. Ann. Trop. Med. Parasitol. (2003) [Pubmed]
  4. Effect of single dose of secnidazole in treatment of intestinal amoebiasis. Omrani, G., Rastegar-Lari, A., Khamseh, M. JPMA. The Journal of the Pakistan Medical Association. (1995) [Pubmed]
  5. Effects of ketoconazole on the proliferation and cell cycle of human cancer cell lines. Forgue-Lafitte, M.E., Coudray, A.M., Fagot, D., Mester, J. Cancer Res. (1992) [Pubmed]
  6. ICH guidance in practice: establishment of inherent stability of secnidazole and development of a validated stability-indicating high-performance liquid chromatographic assay method. Bakshi, M., Singh, S. Journal of pharmaceutical and biomedical analysis. (2004) [Pubmed]
  7. Secnidazole vs. paromomycin: comparative antiprotozoan treatment in captive primates. Gracenea, M., Gómez, M.S., Fernández, J., Feliu, C. J. Med. Primatol. (1998) [Pubmed]
  8. Randomized double-blind trial of metronidazole versus secnidazole in amebic liver abscess. Bhatia, S., Karnad, D.R., Oak, J.L. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology. (1998) [Pubmed]
  9. Ornidazole and secnidazole in the treatment of symptomatic intestinal amoebiasis in childhood. Toppare, M.F., Kitapçi, F., Senses, D.A., Yalcinkaya, F., Kaya, I.S., Dilmen, U. Tropical doctor. (1994) [Pubmed]
  10. Randomized trial of a quadruple-drug regimen and a triple-drug regimen for eradication of Helicobacter pylori: long-term follow-up study. Kumar, D., Ahuja, V., Dhar, A., Sharma, M.P. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology. (2001) [Pubmed]
  11. Low efficacy of an ultra-short term, once-daily dose triple therapy with omeprazole, azithromycin, and secnidazole for Helicobacter pylori eradication in peptic ulcer. Silva, F.M., Eisig, J.N., Chehter, E.Z., da Silva, J.J., Laudanna, A.A. Revista do Hospital das Clínicas. (2002) [Pubmed]
  12. Dientamoeba fragilis, a neglected cause of diarrhea, successfully treated with secnidazole. Girginkardeşler, N., Coşkun, S., Cüneyt Balcioğlu, I., Ertan, P., Ok, U.Z. Clin. Microbiol. Infect. (2003) [Pubmed]
  13. Secnidazole concentrations in plasma and crevicular fluid after a single oral dose. Tenenbaum, H., Cuisinier, F.J., Le Liboux, A., Pichard, E., Montay, G., Frydman, A. Journal of clinical periodontology. (1993) [Pubmed]
  14. Interactions between amphotericin B and nitroimidazoles against Candida albicans. Cury, A.E., Hirschfeld, M.P. Mycoses (1997) [Pubmed]
  15. Spectrophotometric and HPLC determination of secnidazole in pharmaceutical tablets. El Wallily, A.F., Abdine, H.H., Razak, O.A., Zamel, S. Journal of pharmaceutical and biomedical analysis. (2000) [Pubmed]
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