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Chemical Compound Review

AC1NPVHN     benzotriazole

Synonyms: 1H-benzotriazol-1-ium
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Disease relevance of Pseudoazimidobenzene


High impact information on Pseudoazimidobenzene


Biological context of Pseudoazimidobenzene

  • By contrast, intermediates 11b-d on treatment with zinc bromide loose a molecule of benzotriazole followed by intramolecular cyclization of the resulting intermediates 12b-d to provide the 2,3- and 1,2,3-substituted indenes 13b-d in good yields [10].
  • Reaction kinetics of the aromatase enzyme and of a new nonsteroidal aromatase inhibitor, R 76 713 (6-[(4-chlorophenyl)(1H-1,2,4-triazol-1-yl)-methyl]-1-methyl-1H- benzotriazole), were studied in ovarian homogenates obtained from pregnant mare's serum gonadotropin (PMSG)-injected female Wistar rats [11].
  • The possibility of cross-reactions between Tinuvin P and various substituted benzotriazole compounds was investigated [12].
  • On the use of 1H-NMR and 13C-NMR chemical shifts in a QSAR of benzotriazole derivatives [13].
  • Culturing plants in triazole-amended hydroponic solutions at different pH values did not strongly affect the biomass production, water uptake, and benzotriazole uptake characteristics [14].

Associations of Pseudoazimidobenzene with other chemical compounds


Gene context of Pseudoazimidobenzene

  • A series of benzotriazole phenyldifluoromethylphosphonic acids were found to be potent PTP-1B inhibitors [17].
  • Diels-Alder cycloaddition has been used to add a benzotriazole azo dye to a diene tagged oligonucleotide to generate unique SERRS signals at 10 attomoles [18].
  • R76713 (6-[(4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl]-1-methyl-1H- benzotriazole) is a selective, non-steroidal aromatase inhibitor containing an asymmetric carbon atom [19].
  • SERRS dyes. Part 3. Synthesis of reactive benzotriazole azo dyes for surface enhanced resonance Raman scattering [20].
  • The introduction of substituents on the benzotriazole ring did not improve the affinity to the 5-HT1A receptor, compared to the previously described unsubstituted derivatives [21].

Analytical, diagnostic and therapeutic context of Pseudoazimidobenzene


  1. Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease. Wu, C.Y., King, K.Y., Kuo, C.J., Fang, J.M., Wu, Y.T., Ho, M.Y., Liao, C.L., Shie, J.J., Liang, P.H., Wong, C.H. Chem. Biol. (2006) [Pubmed]
  2. Toxicity of benzotriazole and benzotriazole derivatives to three aquatic species. Pillard, D.A., Cornell, J.S., Dufresne, D.L., Hernandez, M.T. Water Res. (2001) [Pubmed]
  3. Contact dermatitis to 1-H benzotriazole. Ducombs, G., Tamisier, J.M., Texier, L. Contact Derm. (1980) [Pubmed]
  4. Sensitization potential of benzotriazole. Maurer, T., Meier, F. Contact Derm. (1984) [Pubmed]
  5. Fundamental structure-activity relationships associated with a new structural class of respiratory syncytial virus inhibitor. Yu, K.L., Zhang, Y., Civiello, R.L., Kadow, K.F., Cianci, C., Krystal, M., Meanwell, N.A. Bioorg. Med. Chem. Lett. (2003) [Pubmed]
  6. The effect of minor-groove hydrogen-bond acceptors and donors on the stability and replication of four unnatural base pairs. Matsuda, S., Henry, A.A., Schultz, P.G., Romesberg, F.E. J. Am. Chem. Soc. (2003) [Pubmed]
  7. Inhibition of peripheral aromatization in the male cynomolgus monkey by a novel nonsteroidal aromatase inhibitor (R 76713). Tuman, R.W., Morris, D.M., Wallace, N.H., Bowden, C.R. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  8. The structural basis for the selectivity of benzotriazole inhibitors of PTP1B. Scapin, G., Patel, S.B., Becker, J.W., Wang, Q., Desponts, C., Waddleton, D., Skorey, K., Cromlish, W., Bayly, C., Therien, M., Gauthier, J.Y., Li, C.S., Lau, C.K., Ramachandran, C., Kennedy, B.P., Asante-Appiah, E. Biochemistry (2003) [Pubmed]
  9. Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs. Mokrosz, J.L., Paluchowska, M.H., Chojnacka-Wójcik, E., Filip, M., Charakchieva-Minol, S., Dereń-Wesołek, A., Mokrosz, M.J. J. Med. Chem. (1994) [Pubmed]
  10. General and efficient insertion of carbons carrying benzotriazole. Katritzky, A.R., Bobrov, S., Kirichenko, K., Ji, Y. J. Org. Chem. (2004) [Pubmed]
  11. Aromatase inhibition by R 76 713: a kinetic analysis in rat ovarian homogenates. Krekels, M.D., Wouters, W., De Coster, R. Steroids (1990) [Pubmed]
  12. Contact allergy to the UV-absorber Tinuvin P in plastics. Niklasson, B., Björkner, B. Contact Derm. (1989) [Pubmed]
  13. On the use of 1H-NMR and 13C-NMR chemical shifts in a QSAR of benzotriazole derivatives. Caliendo, G., La Rotonda, M.I., Novellino, E., Silipo, C., Vittoria, A. Prog. Clin. Biol. Res. (1989) [Pubmed]
  14. Temperature and pH effects on plant uptake of benzotriazoles by sunflowers in hydroponic culture. Castro, S., Davis, L.C., Erickson, L.E. International journal of phytoremediation. (2004) [Pubmed]
  15. Contact sensitivity to Tinuvin P in mice. Ikarashi, Y., Tsuchiya, T., Nakamura, A. Contact Derm. (1994) [Pubmed]
  16. New polymeric benzotriazole reagents for off-line derivatizations of amines and polyamines in HPLC. Gao, C.X., Chou, T.Y., Colgan, S.T., Krull, I.S., Dorschel, C., Bidlingmeyer, B. Journal of chromatographic science. (1988) [Pubmed]
  17. Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors. Lau, C.K., Bayly, C.I., Gauthier, J.Y., Li, C.S., Therien, M., Asante-Appiah, E., Cromlish, W., Boie, Y., Forghani, F., Desmarais, S., Wang, Q., Skorey, K., Waddleton, D., Payette, P., Ramachandran, C., Kennedy, B.P., Scapin, G. Bioorg. Med. Chem. Lett. (2004) [Pubmed]
  18. A new approach to oligonucleotide labelling using Diels-Alder cycloadditions and detection by SERRS. Fruk, L., Grondin, A., Smith, W.E., Graham, D. Chem. Commun. (Camb.) (2002) [Pubmed]
  19. Comparative effects of the aromatase inhibitor R76713 and of its enantiomers R83839 and R83842 on steroid biosynthesis in vitro and in vivo. Wouters, W., De Coster, R., van Dun, J., Krekels, M.D., Dillen, A., Raeymaekers, A., Freyne, E., Van Gelder, J., Sanz, G., Venet, M. J. Steroid Biochem. Mol. Biol. (1990) [Pubmed]
  20. SERRS dyes. Part 3. Synthesis of reactive benzotriazole azo dyes for surface enhanced resonance Raman scattering. Enright, A., Fruk, L., Grondin, A., McHugh, C.J., Smith, W.E., Graham, D. The Analyst. (2004) [Pubmed]
  21. Synthesis and pharmacological evaluation of aryl/heteroaryl piperazinyl alkyl benzotriazoles as ligands for some serotonin and dopamine receptor subtypes. Boido, A., Boido, C.C., Sparatore, F. Farmaco (2001) [Pubmed]
  22. A PEGylated fibrin patch for mesenchymal stem cell delivery. Zhang, G., Wang, X., Wang, Z., Zhang, J., Suggs, L. Tissue engineering. (2006) [Pubmed]
  23. Discharge of three benzotriazole corrosion inhibitors with municipal wastewater and improvements by membrane bioreactor treatment and ozonation. Weiss, S., Jakobs, J., Reemtsma, T. Environ. Sci. Technol. (2006) [Pubmed]
  24. Hydrogen bond equilibrium constants for the complexes of benzotriazole and some nucleoside derivatives. A near infrared study. Buchet, R., Dion, A. J. Biomol. Struct. Dyn. (1986) [Pubmed]
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