Disease relevance of Pseudoazimidobenzene

• Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease [1].
• Our current research compared the toxicity of benzotriazole (BT), two methylbenzotriazole (MeBT) isomers, and butylbenzotriazole (BBT) [2].
• Contact dermatitis to 1-H benzotriazole [3].
• In only 3 animals, induced and challenged according to the maximization protocol with more than 100 times the normal use concentration, were slight erythemas elicited with the commercial grade of benzotriazole [4].
• Structure-activity relationships surrounding the dialkylamino side chain of a series of benzotriazole-derived inhibitors of respiratory syncytial virus fusion based on the screening lead 1a were examined [5].

High impact information on Pseudoazimidobenzene

• The benzotriazole self-pair is extended with an efficiency that is only 200-fold less than a correct natural base pair [6].
• R 76713 (6-[(4-chlorophenyl)(1-H-1,2,4-trizol-1-yl)methyl]1-H benzotriazole) is a highly potent and selective inhibitor of the aromatase enzyme both in vitro and in vivo [7].
• The structural basis for the selectivity of benzotriazole inhibitors of PTP1B [8].
• It was shown that the benzotriazole moiety contributes to both the 5-HT1A and 5-HT2 receptor affinity [9].
• A new set of 4-alkyl-1-(o-methoxyphenyl)piperazines containing a terminal benzotriazole fragment were synthesized, and their 5-HT1A and 5-HT2 affinity was determined [9].

Biological context of Pseudoazimidobenzene

• By contrast, intermediates 11b-d on treatment with zinc bromide loose a molecule of benzotriazole followed by intramolecular cyclization of the resulting intermediates 12b-d to provide the 2,3- and 1,2,3-substituted indenes 13b-d in good yields [10].
• Reaction kinetics of the aromatase enzyme and of a new nonsteroidal aromatase inhibitor, R 76 713 (6-[(4-chlorophenyl)(1H-1,2,4-triazol-1-yl)-methyl]-1-methyl-1H- benzotriazole), were studied in ovarian homogenates obtained from pregnant mare's serum gonadotropin (PMSG)-injected female Wistar rats [11].
• The possibility of cross-reactions between Tinuvin P and various substituted benzotriazole compounds was investigated [12].
• On the use of 1H-NMR and 13C-NMR chemical shifts in a QSAR of benzotriazole derivatives [13].
• Culturing plants in triazole-amended hydroponic solutions at different pH values did not strongly affect the biomass production, water uptake, and benzotriazole uptake characteristics [14].

Associations of Pseudoazimidobenzene with other chemical compounds

• A cross-reaction test between Tinuvin P and various substituted benzotriazole ultraviolet light (UV) absorbers was performed [15].
• The limits of detection are 1 to 2 pmol for polyamines, such as cadaverine, putrescine, and 1,7-diaminoheptane, using the benzotriazole fluorenyl reagent followed by fluorescence detection [16].

Gene context of Pseudoazimidobenzene

• A series of benzotriazole phenyldifluoromethylphosphonic acids were found to be potent PTP-1B inhibitors [17].
• Diels-Alder cycloaddition has been used to add a benzotriazole azo dye to a diene tagged oligonucleotide to generate unique SERRS signals at 10 attomoles [18].
• R76713 (6-[(4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl]-1-methyl-1H- benzotriazole) is a selective, non-steroidal aromatase inhibitor containing an asymmetric carbon atom [19].
• SERRS dyes. Part 3. Synthesis of reactive benzotriazole azo dyes for surface enhanced resonance Raman scattering [20].
• The introduction of substituents on the benzotriazole ring did not improve the affinity to the 5-HT1A receptor, compared to the previously described unsubstituted derivatives [21].

Analytical, diagnostic and therapeutic context of Pseudoazimidobenzene

• We have developed a PEGylated fibrin patch for MSC transplantation by modifying fibrinogen (Fgn) with the benzotriazole carbonate derivative of PEG to create secondary crosslinking [22].
• Discharge of three benzotriazole corrosion inhibitors with municipal wastewater and improvements by membrane bioreactor treatment and ozonation [23].
• Approximate hydrogen bond association constants were determined by near infrared spectroscopy for pairs formed by benzotriazole and a number of nucleoside derivatives [24].
• New polymeric benzotriazole reagents for off-line derivatizations of amines and polyamines in HPLC [16].

References