Gene Review:
Ptpn1 - protein tyrosine phosphatase, non-receptor...
Mus musculus
Synonyms:
PTP-1B, PTP-HA2, PTP1B, Protein-tyrosine phosphatase 1B, Protein-tyrosine phosphatase HA2, ...
Rondinone,
Kendra K. Bence,
Eun-Gyoung Hong,
Bentires-Alj,
Butler,
Trevillyan,
Trevillyan,
Morgan,
Zinker,
Frost,
Crosby,
Kroeger,
Jason K. Kim,
Jirousek,
Xie,
Jirousek,
Clampit,
Butler,
Murray,
Clampit,
Opgenorth,
Ulrich,
Clampit,
Jirousek,
Gum,
Ulrich,
Ciurlionis,
Monia,
Trevillyan,
Neel,
Waring,
Aoki,
Bhanot,
Ulrich,
Matsuda,
Barbara B. Kahn,
Waring,
Hwi Jin Ko,
Frost,
Monia,
Benjamin G. Neel,
Gaede,
McKay,
Heindel,
Ulrich,
Nimesh Mody,
Reilly,
Jirousek,
Trevillyan,
Zinker,
Janice M. Zabolotny,
Young-Bum Kim,
Laura A. Welsh,
Erin E. Kershaw,
Benjamin G. Neel,
Barbara B. Kahn,
Jolly,
Rondinone,
Gum,
Jacobson,
Gum,
Zinker,
Mirela Delibegovic,
Frost,
Rondinone,
Koterski,
Berg,
Clampit,
Kroeger,
Koterski,
Zinker,
Wilcox,
Waring,
Reilly,
Kroeger,
Gum,
Rondinone,
- Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer. Bentires-Alj, M., Neel, B.G. Cancer Res. (2007)
- Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis. Rondinone, C.M., Trevillyan, J.M., Clampit, J., Gum, R.J., Berg, C., Kroeger, P., Frost, L., Zinker, B.A., Reilly, R., Ulrich, R., Butler, M., Monia, B.P., Jirousek, M.R., Waring, J.F. Diabetes (2002)
- Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis. Julien, S.G., Dubé, N., Read, M., Penney, J., Paquet, M., Han, Y., Kennedy, B.P., Muller, W.J., Tremblay, M.L. Nat. Genet. (2007)
- Neuronal PTP1B regulates body weight, adiposity and leptin action. Bence, K.K., Delibegovic, M., Xue, B., Gorgun, C.Z., Hotamisligil, G.S., Neel, B.G., Kahn, B.B. Nat. Med. (2006)
- Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Elchebly, M., Payette, P., Michaliszyn, E., Cromlish, W., Collins, S., Loy, A.L., Normandin, D., Cheng, A., Himms-Hagen, J., Chan, C.C., Ramachandran, C., Gresser, M.J., Tremblay, M.L., Kennedy, B.P. Science (1999)
- Galpha(i2) enhances insulin signaling via suppression of protein-tyrosine phosphatase 1B. Tao, J., Malbon, C.C., Wang, H.Y. J. Biol. Chem. (2001)
- PTP1B regulates leptin signal transduction in vivo. Zabolotny, J.M., Bence-Hanulec, K.K., Stricker-Krongrad, A., Haj, F., Wang, Y., Minokoshi, Y., Kim, Y.B., Elmquist, J.K., Tartaglia, L.A., Kahn, B.B., Neel, B.G. Dev. Cell (2002)
- Protein-Tyrosine Phosphatase 1B-Deficient Myocytes Show Increased Insulin Sensitivity and Protection Against Tumor Necrosis Factor-{alpha}-Induced Insulin Resistance. Nieto-Vazquez, I., Fernández-Veledo, S., de Alvaro, C., Rondinone, C.M., Valverde, A.M., Lorenzo, M. Diabetes (2007)
- PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat. Waring, J.F., Ciurlionis, R., Clampit, J.E., Morgan, S., Gum, R.J., Jolly, R.A., Kroeger, P., Frost, L., Trevillyan, J., Zinker, B.A., Jirousek, M., Ulrich, R.G., Rondinone, C.M. Mol. Cell. Endocrinol. (2003)
- Liver X receptor agonists ameliorate TNFalpha-induced insulin resistance in murine brown adipocytes by downregulating protein tyrosine phosphatase-1B gene expression. Fern??ndez-Veledo, S., Nieto-Vazquez, I., Rondinone, C.M., Lorenzo, M. Diabetologia (2006)
- Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes. Gonzalez-Rodriguez, A., Clampit, J.E., Escribano, O., Benito, M., Rondinone, C.M., Valverde, A.M. Endocrinology (2007)
- Effects of small interference RNA against PTP1B and TCPTP on insulin signaling pathway in mouse liver: Evidence for non-synergetic cooperation. Xu, J., Li, L., Hong, J., Huang, W. Cell Biol. Int. (2007)
- Overexpression of protein-tyrosine phosphatase-1B in adipocytes inhibits insulin-stimulated phosphoinositide 3-kinase activity without altering glucose transport or Akt/Protein kinase B activation. Venable, C.L., Frevert, E.U., Kim, Y.B., Fischer, B.M., Kamatkar, S., Neel, B.G., Kahn, B.B. J. Biol. Chem. (2000)
- PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice. Zinker, B.A., Rondinone, C.M., Trevillyan, J.M., Gum, R.J., Clampit, J.E., Waring, J.F., Xie, N., Wilcox, D., Jacobson, P., Frost, L., Kroeger, P.E., Reilly, R.M., Koterski, S., Opgenorth, T.J., Ulrich, R.G., Crosby, S., Butler, M., Murray, S.F., McKay, R.A., Bhanot, S., Monia, B.P., Jirousek, M.R. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice. Kushner, J.A., Haj, F.G., Klaman, L.D., Dow, M.A., Kahn, B.B., Neel, B.G., White, M.F. Diabetes (2004)
- Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B. Liu, G., Szczepankiewicz, B.G., Pei, Z., Janowick, D.A., Xin, Z., Hajduk, P.J., Abad-Zapatero, C., Liang, H., Hutchins, C.W., Fesik, S.W., Ballaron, S.J., Stashko, M.A., Lubben, T., Mika, A.K., Zinker, B.A., Trevillyan, J.M., Jirousek, M.R. J. Med. Chem. (2003)
- The Role of the C-terminal Domain of Protein Tyrosine Phosphatase-1B in Phosphatase Activity and Substrate Binding. Picha, K.M., Patel, S.S., Mandiyan, S., Koehn, J., Wennogle, L.P. J. Biol. Chem. (2007)
- Sodium stibogluconate is a potent inhibitor of protein tyrosine phosphatases and augments cytokine responses in hemopoietic cell lines. Pathak, M.K., Yi, T. J. Immunol. (2001)
- Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B. Delibegovic, M., Bence, K.K., Mody, N., Hong, E.G., Ko, H.J., Kim, J.K., Kahn, B.B., Neel, B.G. Mol. Cell. Biol. (2007)
- Basal activation of p70S6K results in adipose-specific insulin resistance in protein-tyrosine phosphatase 1B -/- mice. Ruffolo, S.C., Forsell, P.K., Yuan, X., Desmarais, S., Himms-Hagen, J., Cromlish, W., Wong, K.K., Kennedy, B.P. J. Biol. Chem. (2007)
- Impaired integrin-mediated adhesion and signaling in fibroblasts expressing a dominant-negative mutant PTP1B. Arregui, C.O., Balsamo, J., Lilien, J. J. Cell Biol. (1998)
- Essential tyrosine residues for interaction of the non-receptor protein-tyrosine phosphatase PTP1B with N-cadherin. Rhee, J., Lilien, J., Balsamo, J. J. Biol. Chem. (2001)
- A cytosolic protein-tyrosine phosphatase PTP1B specifically dephosphorylates and deactivates prolactin-activated STAT5a and STAT5b. Aoki, N., Matsuda, T. J. Biol. Chem. (2000)
- Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. Cheng, A., Uetani, N., Simoncic, P.D., Chaubey, V.P., Lee-Loy, A., McGlade, C.J., Kennedy, B.P., Tremblay, M.L. Dev. Cell (2002)
- Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts. Buckley, D.A., Cheng, A., Kiely, P.A., Tremblay, M.L., O'Connor, R. Mol. Cell. Biol. (2002)
- Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product. Crews, C.M., Erikson, R.L. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. Zabolotny, J.M., Kim, Y.B., Welsh, L.A., Kershaw, E.E., Neel, B.G., Kahn, B.B. J. Biol. Chem. (2008)
- Genetic ablation of protein tyrosine phosphatase 1B accelerates lymphomagenesis of p53-null mice through the regulation of B-cell development. Dubé, N., Bourdeau, A., Heinonen, K.M., Cheng, A., Loy, A.L., Tremblay, M.L. Cancer Res. (2005)
- Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice. Gum, R.J., Gaede, L.L., Koterski, S.L., Heindel, M., Clampit, J.E., Zinker, B.A., Trevillyan, J.M., Ulrich, R.G., Jirousek, M.R., Rondinone, C.M. Diabetes (2003)
- Differential intracellular compartmentalization of phosphotyrosine phosphatases in a glial cell line: TC-PTP versus PTP-1B. Faure, R., Posner, B.I. Glia (1993)
- Improvement of peripheral endothelial dysfunction by protein tyrosine phosphatase inhibitors in heart failure. Vercauteren, M., Remy, E., Devaux, C., Dautreaux, B., Henry, J.P., Bauer, F., Mulder, P., Hooft van Huijsduijnen, R., Bombrun, A., Thuillez, C., Richard, V. Circulation (2006)