Gene Review:
Cyp19a1 - cytochrome P450, family 19, subfamily a,...
Rattus norvegicus
Synonyms:
Arom, Aromatase, CYPXIX, Cyp19, Cyp19a, ...
- The structure of cDNA clones encoding the aromatase P-450 isolated from a rat Leydig cell tumor line demonstrates differential processing of aromatase mRNA in rat ovary and a neoplastic cell line. Lephart, E.D., Peterson, K.G., Noble, J.F., George, F.W., McPhaul, M.J. Mol. Cell. Endocrinol. (1990)
- Expression of aromatase P450 is increased in spontaneous prolactinomas of aged rats. Carretero, J., Burks, D.J., Vázquez, G., Rubio, M., Hernández, E., Bodego, P., Vázquez, R. Pituitary (2002)
- Heat stress diminishes gonadotropin receptor expression and enhances susceptibility to apoptosis of rat granulosa cells. Shimizu, T., Ohshima, I., Ozawa, M., Takahashi, S., Tajima, A., Shiota, M., Miyazaki, H., Kanai, Y. Reproduction (2005)
- Sex differences and androgen-dependent regulation of aromatase (CYP19) mRNA expression in the developing and adult rat brain. Lauber, M.E., Sarasin, A., Lichtensteiger, W. J. Steroid Biochem. Mol. Biol. (1997)
- Brain androgen-inducible aromatase is critical for adolescent organization of environment-specific social interaction in male rats. Kellogg, C.K., Lundin, A. Hormones and behavior. (1999)
- Effect of liver regeneration on hepatic cytochrome P450 isozymes and serum sex steroids in the male rat. Liddle, C., Murray, M., Farrell, G.C. Gastroenterology (1989)
- Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons. Hojo, Y., Hattori, T.A., Enami, T., Furukawa, A., Suzuki, K., Ishii, H.T., Mukai, H., Morrison, J.H., Janssen, W.G., Kominami, S., Harada, N., Kimoto, T., Kawato, S. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Aromatase, the enzyme responsible for estrogen biosynthesis, is expressed by human and rat glioblastomas. Yague, J.G., Lavaque, E., Carretero, J., Azcoitia, I., Garcia-Segura, L.M. Neurosci. Lett. (2004)
- The effects of the aromatase inhibitor delta 1-testolactone on gonadotropin release and steroid metabolism in polycystic ovarian disease. Dunaif, A., Longcope, C., Canick, J., Badger, T., Crowley, W.F. J. Clin. Endocrinol. Metab. (1985)
- Effects of the steroidal aromatase inhibitor exemestane and the nonsteroidal aromatase inhibitor letrozole on bone and lipid metabolism in ovariectomized rats. Goss, P.E., Qi, S., Cheung, A.M., Hu, H., Mendes, M., Pritzker, K.P. Clin. Cancer Res. (2004)
- Oxytocin mediates the estrogen-dependent contractile activity of endothelin-1 in human and rabbit epididymis. Filippi, S., Morelli, A., Vignozzi, L., Vannelli, G.B., Marini, M., Ferruzzi, P., Mancina, R., Crescioli, C., Mondaini, N., Forti, G., Ledda, F., Maggi, M. Endocrinology (2005)
- Liver receptor homolog-1 stimulates the progesterone biosynthetic pathway during follicle-stimulating hormone-induced granulosa cell differentiation. Saxena, D., Safi, R., Little-Ihrig, L., Zeleznik, A.J. Endocrinology (2004)
- The expression of aromatase in gonadotropes is regulated by estradiol and gonadotropin-releasing hormone in a manner that differs from the regulation of luteinizing hormone. Galmiche, G., Richard, N., Corvaisier, S., Kottler, M.L. Endocrinology (2006)
- Regulation of aromatase gene expression in purified germ cells of adult male rats: effects of transforming growth factor beta, tumor necrosis factor alpha, and cyclic adenosine 3',5'-monosphosphate. Bourguiba, S., Chater, S., Delalande, C., Benahmed, M., Carreau, S. Biol. Reprod. (2003)
- Duration of estrogen exposure prior to follicle-stimulating hormone stimulation is critical to granulosa cell growth and differentiation in rats. Reilly, C.M., Cannady, W.E., Mahesh, V.B., Stopper, V.S., De Sevilla, L.M., Mills, T.M. Biol. Reprod. (1996)
- The differential effects of the gonadotropin receptors on aromatase expression in primary cultures of immature rat granulosa cells are highly dependent on the density of receptors expressed and the activation of the inositol phosphate cascade. Donadeu, F.X., Ascoli, M. Endocrinology (2005)
- Aromatase is abundantly expressed by neonatal rat penis but downregulated in adulthood. Jesmin, S., Mowa, C.N., Sakuma, I., Matsuda, N., Togashi, H., Yoshioka, M., Hattori, Y., Kitabatake, A. J. Mol. Endocrinol. (2004)
- Brain aromatase expression after experimental stroke: topography and time course. Carswell, H.V., Dominiczak, A.F., Garcia-Segura, L.M., Harada, N., Hutchison, J.B., Macrae, I.M. J. Steroid Biochem. Mol. Biol. (2005)
- A gonadotropin-like thermostable peptide, prepared from bovine anterior pituitary, inducing spermiation in the frog Rana esculenta (L.) and binding to a rat ovarian FSH receptor. Renlund, S., Hallin, P. Gen. Comp. Endocrinol. (1985)
- Aromatase inhibitors prevent granulosa cell differentiation: an obligatory role for estrogens in luteinizing hormone receptor expression. Knecht, M., Brodie, A.M., Catt, K.J. Endocrinology (1985)
- Insulin-like growth factor-I, regulating aromatase expression through steroidogenic factor 1, supports estrogen-dependent tumor Leydig cell proliferation. Sirianni, R., Chimento, A., Malivindi, R., Mazzitelli, I., Andò, S., Pezzi, V. Cancer Res. (2007)
- The effect of anabolic-androgenic steroids on aromatase activity and androgen receptor binding in the rat preoptic area. Roselli, C.E. Brain Res. (1998)
- Epidermal growth factor influences growth and differentiation of rat granulosa cells. Bendell, J.J., Dorrington, J.H. Endocrinology (1990)
- Interleukin-6 decreases estrogen production and messenger ribonucleic acid expression encoding aromatase during in vitro cytodifferentiation of rat granulosa cell. Tamura, K., Kawaguchi, T., Hara, T., Takatoshi, S., Tohei, A., Miyajima, A., Seishi, T., Kogo, H. Mol. Cell. Endocrinol. (2000)
- The role of aromatization in the restoration of male rat reproductive behavior. Vagell, M.E., McGinnis, M.Y. J. Neuroendocrinol. (1997)
- Growth hormone and insulin-like growth factor-I accelerate PMSG-induced differentiation of granulosa cells. Hutchinson, L.A., Findlay, J.K., Herington, A.C. Mol. Cell. Endocrinol. (1988)
- Expression and functional analysis of liver receptor homologue 1 as a potential steroidogenic factor in rat ovary. Liu, D.L., Liu, W.Z., Li, Q.L., Wang, H.M., Qian, D., Treuter, E., Zhu, C. Biol. Reprod. (2003)
- Site of action of androgens on follicle-stimulating hormone-induced aromatase activity in cultured rat granulosa cells. Daniel, S.A., Armstrong, D.T. Endocrinology (1984)
- Differential response of luteinizing hormone receptor and steroidogenic enzyme gene expression to human chorionic gonadotropin stimulation in the neonatal and adult rat testis. Pakarinen, P., Vihko, K.K., Voutilainen, R., Huhtaniemi, I. Endocrinology (1990)
- Direct inhibitory effect of gonadotropin-releasing hormone upon follicle-stimulating hormone induction of luteinizing hormone receptor and aromatase activity in rat granulosa cells. Hsueh, A.J., Wang, C., Erickson, G.F. Endocrinology (1980)
- Unaltered development of the initial follicular waves and normal pubertal onset in female rats after neonatal deletion of the follicular reserve. Guigon, C.J., Mazaud, S., Forest, M.G., Brailly-Tabard, S., Coudouel, N., Magre, S. Endocrinology (2003)
- Truncated equine LH beta and asparagine(56)-deglycosylated equine LH alpha combine to produce a potent FSH antagonist. Butnev, V.Y., Singh, V., Nguyen, V.T., Bousfield, G.R. J. Endocrinol. (2002)